Cabenuva / injectible = liver?

[AZBikerDad]

Hello
I am considering a switch from Biktarvy to either Dovato or Cabenuva.  I am hoping someone can provide me clear information.  Is there a difference in the possible negative effects to the liver when a medication is taken via injection rather than orally?  Is a medication taken through injection less toxic to the liver than if the medication was taken orally?

Hope that makes sense.
Thanks 

[Dogman]

I switched from Bik to Dovato a year ago, glad I did. Slightly bigger pill, and a shorter half life, so being late or missing a dose can be more impactful than doing the same with Bik. I've had no side effects (knock on wood), all my follow ups - now doing 6 monthly, remained undetectable, and my overall #'s weren't as bad as they were on Bik. (cholesterol etc).  I am considering Cabenuva as well, though my doctor hasn't encouraged it and said it's very expensive etc etc. I would be interested to hear what you find out about the impact on the liver with an injectable. Good luck and best wishes.

[AZBikerDad]

Thank you, Dogman.  Glad to hear that the Dovato seems to be working out for you.  It is most likely the switch I will make.  High cholesterol is an issue for me right now and I am hoping that once I'm on the Dovato I might see an improvement.  There is talk that improved injectable options are on the horizon (even less frequent administration of the drug).  I think I will hold off until we see more and even better options.  If I am able to find out about the effect on liver health, I will be sure to report back here.
Best regards

[Dogman]

Thank you, Dogman.  Glad to hear that the Dovato seems to be working out for you.  It is most likely the switch I will make.  High cholesterol is an issue for me right now and I am hoping that once I'm on the Dovato I might see an improvement.  There is talk that improved injectable options are on the horizon (even less frequent administration of the drug).  I think I will hold off until we see more and even better options.  If I am able to find out about the effect on liver health, I will be sure to report back here.
Best regards

Hey, my cholesterol went through the roof on Bik and didn't improve on Dovato. I will add, I have always had high cholesterol, my calcium score tests are close to perfect - so it's a bit of a contradiction, but anyway.   I started a statin (low dose 10mg), as much as I didn't want to take another pill. Anyway, no side effects from the statin, and last check up (6mo after starting) my cholesterol had halved. So I guess it's doing what it is supposed to.  My doc has told me, there is a twice yearly injection coming, as well as a once weekly pill - no details of which particular combination it will be or when, but those options would be really good. Best of luck.

[AZBikerDad]

Dr.'s appointment today= no to Dovato and no to Cabanuva due to a prior exposure to Hepatitis B. 
I continue on the Biktarvy.