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HIV gene therapy - AGT103-T

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ZachR:
It is a nice one and has made it to human trials. There is some good likelyhood for it to reach phase II and III and hope it does, but one of the potentially serious obstacles would be:
a/ no measurable effect
b/ even if it happens to work, will take at least 5 years to be available if given priority.
c/ serious immunogenicity, which could lead to a pronounced inflammatory effect throughout the body with potential consequences like organ damage and failure.
Only speculating tho, lentiviral vector technology is promising for many diseases, let's hope it grants us a safe functional cure. Even if it doesn't though, it will answer many questions that will help get closer to the real 'cure'.

Expat1:
IF a treatment cured say 90% of people living with HIV, but killed the other 10 %, would you sign  up?

What if it cured 99% and killed only 1%?

What it the final cost/benefit level that is acceptable?  And compare that to current
practices with ART?

No answer from me?  Just a question.

(Maybe only  use with  multidrug resistant HIV after salvage therapy unable to reduce VL below a certain threshold?)

ZachR:

--- Quote from: Expat1 on November 09, 2019, 03:18:18 pm ---IF a treatment cured say 90% of people living with HIV, but killed the other 10 %, would you sign  up?

What if it cured 99% and killed only 1%?
 

--- End quote ---

If it killed 10% it wouldn't be approved for widespread use anyway. In case it killed 1% while successfully curing 99, it would be approved, because numerous interventions used in medicine already have a worse risk/benefit ratio than 99/1.

Let me only remind you that we don't have a 100% guarantee that we'll make it till tomorrow, right?  So demanding 100% from those guys would be unnatural.

Expat1:
Zack, I asked: "Would you sign up?"   Not if it would be approved.  Me no.

IF my CD4 were 25 and I was symtomatic with OIs, maybe. 

em:
that was me over twenty years ago when my ID doc suggested I go on trial testing norvir.   My count was 7 viral load inconceivable large    that i gladly tried thinking even if I die at least I gave every option a try if it did not help me it might help others on the same path .    I would be willing to be selected to try this .  to help push things toward a cure .   I cannot see why anyone would not want to but that is your choice

I hope we live to see this turn out to be cure for everyone's sake 

em

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