Meds, Mind, Body & Benefits > Nutrition & HIV

Any advice for nutrition or supplements for neurological health

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Jim Allen:
Hi Pete,

Really sorry to hear things have not yet started to improve and, that you are not getting support from your GP.

I could understand the misuse concern or even long term use concern but is the GP aware you have been diagnosed with HAND/HAD and that the Diazepam is helping you to manage?

Prehaps the doctor working with you can send a note to your GP or recommend another treatment the GP can agree with? Also, If not already discussed your HIV doctor could check if the ART you are on is optimized to help you with this issue as well.

Wishing you all the best and, just as note if you mentioned studies or any medical claims then please provide peer-reviewed references, thanks.

Best, Jim

https://www.poz.com/basics/hiv-basics/hiv-associated-neurocognitive-disorders-HAND

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454832/
Optimal treatment of HIV-associated neurocognitive disorders: myths and reality. A critical review

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5365228/
Neuropathogenesis of HIV: From Initial Neuroinvasion to HIV-Associated Neurocognitive Disorder (HAND)

https://www.ncbi.nlm.nih.gov/pubmed/28752495
Changing clinical phenotypes of HIV-associated neurocognitive disorders.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4446730/
Long-term prescription opioids and/or benzodiazepines and mortality among HIV-infected and uninfected patients

Lorenzopier:
For anyone who is experiencing cognitive decline or neurological dysfunction despite having there viral load well controlled and suppressed I would definitely suggest making sure you address this issue with your doctor or healthcare specialist who should be able to manage this quality of life issue for you. For me personally, I have noticed that using 600 mg of Acetylcysteine a day with with a meal and 50mg of alpha lipoic acid on a empty stomach definitely enhances my cognitive functions and focusing abilities as well as decreases symptoms of fatigue. Adding 1-2 grams of Glutamine a day on a empty stomach further enhances cognitive function and modulation of fatigue. Just because micronutrients such as these work for me does not necessarily mean that they will work for you as everybody's chemistry, metabolic and immune responses are slightly different.

zach:
Acetylcysteine is a bronchial cough medicine used to treat asthma... it is not a micronutrient, it is a mucolytic

Alpha-lipoic acid has been used in alternative medicine as a possibly effective aid in weight loss, treating diabetic nerve pain, healing wounds, lowering blood sugar, improving skin discoloration caused by vitiligo

Sounds like a cure all snake oil

Glutamine is an amino acid.

In fact, none of the compounds you suggest (and recommend dosages for) are micronutrients.

Nothing you've said is supported by medical science. Your qualified warnings don't make your suggestions any less dangerous.

Lorenzopier:
From https://pubmed.ncbi.nlm.nih.gov/10416949

Toward a New Definition of Essential Nutrients: Is It Now Time for a Third 'Vitamin' Paradigm?

The concepts of vitamin 'deficiency' diseases and the recommended dietary allowances (RDAs) have not kept pace with the growing understanding of the cellular and molecular functions of vitamins and other micronutrients. As a consequence, many researchers and clinicians rely on outdated signs and symptoms in assessing nutritional deficiencies. A new paradigm, presented here, proposes that: (1) deficiencies can be identified on biochemical and molecular levels long before they become clinically visible; (2) the definition of essential micronutrients be broadened to include some carotenoids and flavonoids, as well as various human metabolites, such as coenzyme Q10, carnitine, and alpha-lipoic acid, which are also dietary constituents; (4) individual nutritional requirements are partly fixed by genetics but also dynamically influenced by variations in the body's biochemical milieu and external stresses; and (5) the distinction between nutritional and pharmacological doses of vitamins is meaningless, since high doses of micronutrients may be required to achieve normal metabolic processes in some people.

Lorenzopier:
https://pubmed.ncbi.nlm.nih.gov/19608349

Micronutrients and Amino Acids, Main Regulators of Physiological Processes

Human physiology is supposed to be a complex interaction of regulating processes, in which hormones, genes, their proteins and apoptosis are thought to play a dominant role. We hypothesize that regulation of physiological processes is mainly influenced by amino acids and micronutrients with hormones, proteins, apoptosis and gene modifications being their derivatives. Furthermore, we suppose that the cells power plant, the mitochondrion, is in fact an intracellular bacterium, living in absolute symbiosis. Because of its intracellular existence it depends on the host's micronutrients completely. Within the host these micronutrients regulate their own formation, degradation, uptake and excretion. Known deficiencies, such as iodine and vitamin D, affect billions of people. Many micronutrients neither have been investigated, nor have they been studied in relation to each other and solid data are not available. Optimal levels of many micronutrients and all amino acids are not known. Amino acids, vitamins and minerals are capable of altering gene expression, inducing apoptosis and regulating chemical processes. It makes them highly attractive for creating better health, against low cost, as we have already proven in the case of rickets, cretinism and scurvy in severe deficiencies. By creating optimal living conditions and study mitochondria from a symbiotic point of view we suppose that diseases not only can be prevented, but the course of diseases can be altered as well.

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