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Author Topic: Islatravir-Based HIV Regimen Fails Few Study Participants  (Read 1415 times)

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Offline Jim Allen

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Islatravir-Based HIV Regimen Fails Few Study Participants
« on: October 13, 2020, 05:15:30 am »
To be honest, it doesn't seem like terrible results at 48 & 96 weeks if you ask me. The PLHIV were treatment native and I think it's fair to say they tend to have VL blips with any treatment more frequent at first. Although, it's a small sample size.

In full POZ.com writeup:

in Short:

The study enrolled 121 people with HIV, randomized initially to received islatravir at either 0.25 milligrams, 0.75 mg or 2.25 mg daily plus Pifeltro (doravirine) and lamivudine daily; or they received a fixed-dose combination of Delstrigo (doravirine/tenofovir disoproxil fumarate/lamivudine). The study was set to run for 96 weeks.

Those in the islatravir groups who had a fully suppressed viral load (less than 50) 20 weeks into the study or later were taken off lamivudine at their next clinic visit.

Orkin and her colleagues defined virologic failure as having a viral load of 50 or greater after having achieved full viral suppression at any time during the study, called a rebound. Or this outcome was defined as not achieving a viral load below 50 by week 48 of the study, called a nonresponse.

At week 96 of the study, 86.2% (25 of 29) of those who received 0.25 mg of islatravir had a fully suppressed viral load, as did a respective 90.0% (27 of 30) and 67.7% (21 of 31) of those who received 0.75 mg and 2.25 mg the drug. By comparison, 80.6% (25 of 31) of those who received Delstrigo had a viral load below 50.

During the first 48 weeks of the trial, six participants discontinued treatment due to virologic failure. This included two rebounders each in the 0.25 mg and 0.75 mg of islatravir groups, one nonresponder in the 2.25 mg group and one rebounder in the Delstrigo group.

Following the 48-week mark, one additional participant discontinued treatment due to virologic failure. This person, who was in the 2.25 mg group, saw their virus rebound to 70 at the 72-week point.

All those who experienced virologic failure had a viral load between 50 and 79. This meant that none had a viral load high enough to conduct resistance testing on their virus.

After the seven people who discontinued treatment switched to new HIV regimens, three—one each from the 0.25 mg and 0.75 mg groups and one from the Delstrigo group—continued to have a viral load that was above 50 and yet remained low.

« Last Edit: October 13, 2020, 05:18:00 am by Jim Allen »
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