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Author Topic: Biological mechanism responsible for latent HIV reservoirs?  (Read 2140 times)

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Offline Ptrk3

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Biological mechanism responsible for latent HIV reservoirs?
« on: November 18, 2018, 10:58:57 am »
From the November 16, 2018, edition of Science Daily (HIV/AIDS topics):

Headline:

Majority of HIV persistence during ART due to infected cell proliferation 

Study confirms biological mechanism responsible for latent HIV reservoirs; suggests strategies for a functional HIV cure

Lede paragraph:

"A majority of the HIV-infected cells that persist in HIV-infected individuals even during suppressive antiretroviral therapy (ART) originated from cellular proliferation, not viral replication, according to new research published in Nature Communications."

Link to full story:

https://www.sciencedaily.com/releases/2018/11/181116164503.htm

Link to source material:

https://www.nature.com/articles/s41467-018-06843-5
« Last Edit: November 18, 2018, 11:04:45 am by Ptrk3 »
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Offline Jmarksto

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  • Posts: 667
Re: Biological mechanism responsible for latent HIV reservoirs?
« Reply #1 on: November 25, 2018, 12:26:39 pm »
Thanks for posting these.  This work shows the value of interdisciplinary science bringing the disciplines of oncology, immunology, ecology together.  Here is a short article on the same work written for the non-scientific audience and discussing a very small clinical trial based on the science.

https://tinyurl.com/y6w55wsf
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03/15/12 Negative
06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45% VL 25
02/25/14 CD4   792/37% VL UD
07/09/14 CD4 1004/39% VL UD
11/03/14 CD4   711/34% VL UD
03/13/15 CD4   833/36% VL UD
04/??/15 Truvada & Tivicay
06/01/15 CD4 1100/50% VL UD
10/16/15 CD4   826/43% VL UD
??/??/2017 Descov & Tivicay
2017 VL UD, CD4 stable around 850
2018 VL UD, CD4 stable around 850
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