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Author Topic: HIV gene therapy - AGT103-T  (Read 28341 times)

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Offline Da2020

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Re: HIV gene therapy - AGT103-T
« Reply #50 on: December 26, 2022, 05:21:54 pm »
Link to the paper they have published

https://www.frontiersin.org/articles/10.3389/fmed.2022.1044713/full?utm_medium=email&_hsmi=239180469&_hsenc=p2ANqtz-9jiN8VOy5OIQXQCMAQ7LUBWJrhRNl-iSMa1FGKdiGHbyI7bF-oisORe4ONr60dXTG_uq6Lc-JXwIfzMuZyU0pXj7LsRdx-BctgYU_Q8dznw0vtC3k&utm_content=239180469&utm_source=hs_email

I think there was viral rebound in all the people. They are now trying to make changes to the trail protocol and start phase 2 where they start an ati quicker than they did in phase 1

Offline em

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Re: HIV gene therapy - AGT103-T
« Reply #51 on: January 31, 2023, 12:16:52 pm »
just received an email on this today


AGT Newsletter Graphics vol 16-2
Clinical Trial Progress Update
American Gene Technologies® has recorded data that meets the primary and secondary endpoints of its AGT103-T Phase 1 trial. The Phase 1 trial demonstrated that AGT103-T — an autologous T cell product that has been modified with the AGT103 lentiviral vector for HIV resistance — was well-tolerated in humans and that these enhanced T cells persist in the body, ready to respond to HIV. Data from this first-in-human study of AGT103-T has been published in Frontiers.

 

Having collected data from the Phase 1 clinical trial, we expect to submit the final Phase 1 trial report to the U.S. Food and Drug Administration (FDA) in 2023. American Gene is currently writing the Phase 2 protocol for FDA consideration to continue the clinical development of this potential HIV cure.


Does not seem encouraging or optimistic data disclosure.
If this had been major success I would think there would be more information.
Potential cure meaning in need of money for research and lots of time to get real results toward a cure.  Rather disappointing

Offline Jim Allen

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Re: HIV gene therapy - AGT103-T
« Reply #52 on: January 31, 2023, 12:52:59 pm »
Quote
Does not seem encouraging or optimistic data disclosure.
Potential cure meaning in need of money for research and lots of time to get real results toward a cure.  Rather disappointing

Quote
was well-tolerated in humans

With respect and not trying to sound harsh, but did you really expect much? You and I are not newbies to living with HIV, so we have heard the novel cure, new technology and approach speech a dozen times and more before during the Petri-dish stages and phase 1/2 human testing.

It's phase 1/2, making sure they don't kill the patients, and it sounds like it was well-tolerated, so they didn't kill anyone yet. As for the rest of the data, it's only a few weeks of interruption under a tiny sample of people. Even if AGT103-T gene therapy does nothing, you could have some people or all of them show no rebound under 4-5 months. 

If it gets into phase 2 and then phase 3 by then, data might be more interesting.
« Last Edit: January 31, 2023, 01:08:46 pm by Jim Allen »
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Offline em

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Re: HIV gene therapy - AGT103-T
« Reply #53 on: June 14, 2023, 04:54:17 pm »
email about this had this statement .

  Phase 1 HIV clinical trial in which 100% of participants experienced no adverse effects. In addition, remarkable data from the antiretroviral withdrawal study showed that 100% of the participants completing the withdrawal protocol experienced an effective immune response against their HIV with significant viral suppression in the absence of antiretroviral therapy!

very long email ,   of course seems a bit vaqué . That it might have potential but not a cure yet ?  The cost might be expensive ?

website link :    https://www.americangene.com/milestones/hiv-cure-countdown/

today's email sent a link :    https://www.americangene.com/news-releases/american-gene-technologies-launches-new-spinoff-company-addimmune-to-focus-exclusively-on-development-of-hiv-cure/?utm_medium=email&_hsmi=262514304&_hsenc=p2ANqtz--4RlwoLD7-o7sqWsyscPdRMvgNmzGgfXg-21_v_9-L9jN54e5oZ_TnWN9Alb4odsbat6L2ViY5Oa-w6mVPtKGtH7jQ3g&utm_content=262514304&utm_source=hs_email

Offline Jim Allen

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Re: HIV gene therapy - AGT103-T
« Reply #54 on: June 14, 2023, 05:52:40 pm »
Not much I can say; I mean, we haven't seen the data or any published scientific report  :(

Reading the email, if they get approval for, as claimed, phase two with hundreds of people, it will be more interesting to see results at, let's say, 48 weeks.
« Last Edit: June 14, 2023, 09:59:19 pm by Jim Allen »
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Offline geobee

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Re: HIV gene therapy - AGT103-T
« Reply #55 on: November 21, 2023, 03:37:43 pm »
I got an 2 emails from Quest Labs in San Francisco last week.  They are beginning the recruitment process for the AGT-103 study.

 


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