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Author Topic: Study Low levels of HIV (low-level viremia; LLV) during treatment & health  (Read 2637 times)

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Offline Jim Allen

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Swedish study looking at the impact of low levels of HIV RNA (low-level viremia; LLV) during combination antiretroviral therapy (cART) using data from individuals starting cART 1996–2017.

POZ.com https://www.poz.com/article/lowlevel-viral-replication-tied-worse-health-people-hiv

In short:


After adjusting the data to account for various differences between the cohort members, the study authors found that compared with having viral suppression, having low-level detectable virus was associated with a 2.2-fold increased risk of death.

Breaking down the low-level detectable virus range into two segments, the investigators found that compared with having undetectable virus, having a viral load of 50 to 199 was associated with a 2.2-fold increased risk of death and having a viral load of 200 to 999 was associated with a 2.1-fold increased risk of death. However, only the finding for having a viral load of 50 to 199 was statistically significant, meaning it was not likely driven by chance; the finding for having a viral load of 200 to 999 was not statistically significant.

Compared with having undetectable HIV, having low-level virus was not associated with an increased risk of AIDS or serious non-AIDS adverse health events. However, having a viral load between 200 and 999 was associated with a 2.0-fold increased risk of such negative health outcomes.

“These findings add to mounting evidence that [low-level detectable virus] is associated with worse clinical outcomes,” the study authors concluded.
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Offline xiskza

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Ok this is my case, cant get my viral load below 50. Consider me scared right now

Offline Almost2late

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Ok this is my case, cant get my viral load below 50. Consider me scared right now

It's a study though, and many other variables that aren't discussed may also play a role in these outcomes like, how many participants smoke? Did you know that HIV positive people are more likely to be smokers than HIV negative people?.. just saying.
Were some drug or alchohol abusers? Did they live sedentary lives? Did they eat unhealthy? Or were they adherent to medication?..

1 and a half it took me to get mine fully suppressed, and still had a few blips after that. Yet I've seen negative people my age and younger pass away since, so my take away from this study is give yourself a fighting chance and do all you humanly can to stay healthy.
Diagnosed - Feb.2014 Cd4 13, at 2.8%
Recent - Sept 2021 Cd4 284 at 17.8%

Offline Mightysure

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Ok this is my case, cant get my viral load below 50. Consider me scared right now

This is just one study. As the previous user replied, there are aeveal variables that need to be taken into consideration.

Please don't freak out over one study. A rule of thumb when reading studies is  "Correlation doesn't equal causation".


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