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Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

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Recent Posts

Pages: 1 [2] 3 4 ... 10
11
I Just Tested Poz / Re: So I just messed my life up
« Last post by Ruined Life on Yesterday at 04:15:30 pm »
Well it's all been shit if I'm honest.
Ex Mrs got the contract for her apartment. Moves in on the first.
I spent yesterday ordering things for my daughter's new home.
Stuff I won't see her use.
Stuff for the kitchen and her bedroom.
My ex was excited about it all.
She won't let me buy stuff for her bedroom.
Iv setup a vpn to my house for them to still access my media library and streaming service.
Any little thing I can do to help but I really hate doing it knowing no more family movie nights.
Everything is set up for my daughter's second life.
My ex is well and truly over me.
She's not over the situation.

My health is ok and tablets are working so all good on that front but I feel i wont move on after this. I will have a new outlook on life and will try my best to fill my time and get a better understand what I have done and now dealing with.
I have a scar (HIV) as a reminder.

whilst is cheated i can not accept in this day and age the disease is still around. How are we all this unlucky in life. Whilst i accept things happend for a reason. Not this scar, that's too much.

I still hate the fact I got this. Why did I. I wasn't that person.

I know this is a forum for HIV but this is the mental side of it.
No matter how we get it, good or bad.

It leaves a scar.
12
Research News & Studies / Re: Lack of Sleep May Worsen Inflammation in People With HIV
« Last post by leatherman on Yesterday at 03:44:56 pm »
Quote from: Tonny2 on Yesterday at 02:53:57 pm
Well, it is what it is
ain't that the truth? LOL I've probably been sleeping this little since my aids-years back in the mid-90s. If 2 bouts of aids didn't kill me, nearly 3 decades later lack of sleep sure hasn't had a chance. LOL

Quote from: Tonny2 on Yesterday at 02:53:57 pm
how Larry’s colonoscopy went?
Super-duper! With a couple prior cancellations, Larry was in and out in about an hour. A clean bill of health and come back in a decade. ;) Larry says, "thanks for asking!"
13
Research News & Studies / Re: Lack of Sleep May Worsen Inflammation in People With HIV
« Last post by Tonny2 on Yesterday at 02:53:57 pm »



            ojo.         Hello there!… I have been leaving with insomnia for a long time, they must that I sleep is four hours in a row so, I’m in trouble according to this study. Well, it is what it is… Thanks for sharing.… Hugs



Ps.@ Leatherman, how Larry’s colonoscopy went?
14
Research News & Studies / West of Ireland - Growing number of people when diagnosed have AIDS
« Last post by Jim Allen on Yesterday at 02:26:30 pm »
A little bit of local news, I should add that this is about the West of Ireland and it is largely a rural area.

Full news story - Irish independent:
https://www.independent.ie/irish-news/growing-number-of-people-with-hiv-in-west-of-ireland-already-at-advanced-stage-of-illness-when-diagnosed-study-finds/a67301324.html

In Brief:

Quote
There are concerns over delays in diagnosing people with HIV in the west of Ireland, after a study found a growing number are at an advanced stage of the illness by the time they are aware of it.

The findings are being presented this weekend to the ESCMID Global Congress – which brings together experts in clinical microbiology and infectious diseases – in Barcelona, following a study by a team led by Galway infectious disease consultant Dr Ellen Walsh.

The study calls for the routine screening for HIV of all hospital admissions in the west and also improved access to healthcare for migrant populations

Regional differences have not been explored in Ireland up to now and the study looked at cases over 10 years in University Hospital Galway, from January 2013 to November 2023.

The authors said 69 patients were included – 49 of whom had presented since 2018.

About 50 of the patients were men. Heterosexual transmission occurred in 53.6pc of cases, while 36.2pc were among men who have sex with men.

The authors found that 75pc of advanced diagnoses before 2018 were in Irish-born people, and this declined to 53.1pc in later years.

The findings show 5.5pc died and 55.1pc required hospitalisation, particularly those of an older age. Those admitted had a prolonged length of stay, with a median of 20.5 days, and 13pc were admitted to intensive care.

They found that 75.4pc had attended a healthcare setting before diagnosis, representing “a missed testing opportunity”.
15
Living With HIV / Re: WTH ! Vampire facials
« Last post by Jim Allen on Yesterday at 02:06:48 pm »
Quote from: leatherman on Yesterday at 01:36:00 pm
did the CDC not follow up with all the clients? Did she refuse or ignore notifications? Was this incident not reported enough that this third person was left out of notification? Usually American health departments are pretty hard-core with follow up of sexual partners or those who may have been put at risk.

Wonder if she knew about this risk but just didn't get tested? While I can empathize and sympathize with that sentiment, I would have hoped that that kind of attitude had been left behind in the 90s. Regardless what a sad hard way to get a diagnosis that late. Thankfully for her future, it's not the 90s.

I don't know and nothing would surprise me, it's the CDC ...  One of the last globally to acknowledge the fact that a suppressed VL means you can't pass on HIV, so just a few decades behind and let's not get started on kissing.

Anyhow, I had a read:

CDC: https://www.cdc.gov/mmwr/volumes/73/wr/mm7316a3.htm?s_cid=mm7316a3_w

Quote
Four of the five patients with confirmed spa A–related HIV infections received at least one PRP with microneedling facial treatment at spa A during May–September 2018.

Two of the patients in this cluster (a man and a woman) were engaged in a sexual relationship before and after their diagnoses. Sexual partners of two other patients received negative HIV test results after their partners’ diagnoses, and the remaining patient reported having no sexual partner at the time of diagnosis.

Before receiving a diagnosis of confirmed HIV infection, two of the five patients had previously received a positive rapid HIV test result during routine evaluations for life insurance, one in summer 2016, and the other in fall 2018; however, only one patient reported being notified of the positive screening test result and subsequently had their HIV diagnosis confirmed by a primary care provider in winter 2019.

The other patient received a confirmed HIV diagnosis after hospitalization with an AIDS-defining illness in fall 2021. One patient received their HIV diagnosis in spring 2023 after hospitalization with an AIDS-defining illness.

The two patients who were engaged in a sexual relationship had stage 3 or chronic HIV infections, indicating that their infections were likely attributed to exposures before receipt of cosmetic injection services. The other three patients in this cluster had no known social contact with one another, and no specific mechanism for transmission among these patients was confirmed.

 ::)
16
Research News & Studies / Re: Lack of Sleep May Worsen Inflammation in People With HIV
« Last post by leatherman on Yesterday at 01:51:41 pm »
oh noes! :)
so the alcohol and late nights this weekend didn't help my body live up to it's potential today? well damn. I could have used that as an excuse to not spend the 2 hours pushing the mower around the yard today. LOL I guess I need to tell my dogs to quit waking me up at 5am when Larry gets up for work. :D

Really though I only sleep about 6-7 hours a night anyway. I don't know if I could sleep 8 hrs in a row. And I certainly never take naps. I wake up and throw up. That's kinda a deal breaker on taking naps. ;)
17
Research News & Studies / TDF weight-suppressing effect
« Last post by Jim Allen on Yesterday at 01:48:21 pm »
I had a quick read-through, interesting but nothing new as far as I am aware. It seems to confirm that TDF has a limited weight-suppressing or protective effect that other HIV meds do not have.

Aidsmap article in full:
https://www.aidsmap.com/news/apr-2024/switching-taf-tdf-leads-weight-loss

Quote
Switching from tenofovir alafenamide (TAF) to the older formulation of tenofovir disoproxil (TDF) resulted in modest weight loss in people with HIV in the Swiss HIV Cohort, researchers report in the journal Clinical Infectious Diseases.

Switching from TAF to TDF also brought benefits in the forms of reduced cholesterol and triglycerides.

In contrast, switching from TAF-containing treatment to a two-drug combination of dolutegravir/lamivudine or injectable cabotegravir/rilpivirine did not lead to any changes in weight.


Quote
Of those who switched, 196 (18%) swapped TAF for TDF, 565 (52%) switched to dolutegravir/lamivudine, 115 (10%) to injectable cabotegravir/rilpivirine and 94 (18%) to another antiretroviral combination.

As this was an observational study rather than a randomised trial, the researchers adjusted for confounding factors that might also affect weight (age, sex, Black race, CD4 count and weight at the beginning of follow-up, time on antiretroviral treatment, use of integrase inhibitors, level of physical activity, smoking and use of other medications known to affect weight).

Overall, after adjusting for confounding factors, switching from TAF was associated with a weight loss of 0.60kg after one year, compared to no change in weight in people taking TAF. However, when analysed by the agent to which people switched, it was apparent that participants only lost weight (a median of 1.89kg) if they switched to TDF. Weight remained stable in people who switched to other agents or drug combinations.

Weight loss after switching was greater in women and Black people, and in people who had gained at least 10% in body weight after starting TAF, irrespective of what they switched to.

Quote
In a review of weight changes in clinical trials of newer antiretrovirals, also published in Clinical Infectious Diseases, a group of HIV clinicians concludes that weight tends to increase towards the societal norm in people with HIV after starting antiretroviral treatment. Any difference between regimens is explained by the weight-suppressive effects of TDF or efavirenz rather than weight-additive effects of newer drugs.

They say that anyone considering a switch from TAF to TDF should be aware that the adverse effects of TDF on kidney function on bone mineral density occur more frequently when TDF is used alongside a boosting agent (ritonavir or cobicistat), as these raise tenofovir levels. However, the use of boosted drugs is declining – the most commonly used antiretroviral that requires boosting is darunavir.

In the light of the higher risk of cardiovascular disease in people with HIV and the societal health challenge of obesity, Dr Andrew Hill asks whether the weight-suppressive and lipid-lowering effects of TDF should be considered as an unanticipated benefit of the drug. With this in mind, “clinicians need to decide whether to use TDF, which has the unexpected benefit of causing reductions in weight and lipids, or using TAF, which has lesser effects on markers of bone and renal function.”

Related: 2020
https://www.poz.com/article/study-sheds-light-weight-gain-switching-new-tenofovir
“These data suggest that differences in weight gain between TAF and TDF are likely driven by removal of TDF-associated weight suppression,” the researchers concluded.
18
Living With HIV / Re: WTH ! Vampire facials
« Last post by leatherman on Yesterday at 01:36:00 pm »
Quote
one spa client tested positive for HIV while traveling abroad in 2018. Another tested positive for HIV during routine tests for life insurance in 2018, while a third did not find out she had HIV until a year ago, when hospitalized with an AIDS-related illness
. . .
While the CDC report didn't name the unlicensed spa, the New Mexico Department of Health in 2018 had shut down the VIP Spa in Albuquerque after state inspectors found practices that could potentially spread blood-borne infections, including HIV, to clients.
did the CDC not follow up with all the clients? Did she refuse or ignore notifications? Was this incident not reported enough that this third person was left out of notification? Usually American health departments are pretty hard-core with follow up of sexual partners or those who may have been put at risk.

Wonder if she knew about this risk but just didn't get tested? While I can empathize and sympathize with that sentiment, I would have hoped that that kind of attitude had been left behind in the 90s. Regardless what a sad hard way to get a diagnosis that late. Thankfully for her future, it's not the 90s.
19
Do I Have HIV? / Re: ARS symptoms next day ?
« Last post by Jim Allen on Yesterday at 01:26:14 pm »
You're welcome.
20
Research News & Studies / Lack of Sleep May Worsen Inflammation in People With HIV
« Last post by Jim Allen on Yesterday at 01:24:54 pm »

POZ.com article in full: https://www.poz.com/article/lack-sleep-may-worsen-inflammation-people-hiv

In Brief:

Quote
Inadequate sleep can contribute to increased inflammation in people living with HIV,  according to research presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2024) in Denver.

Bernard Macatangay, MD, and colleagues at the University of Pittsburgh, looked at the effects of short-term sleep deprivation on levels of immune activation and inflammation in HIV-positive people. They also assessed the function of the adenosine pathway, a compensatory mechanism that reduces inflammation and increases the urge to sleep. Prior research has shown that this pathway is dysregulated in people with HIV.

This analysis included 20 people with HIV, mostly men, who were on stable antiretroviral therapy with viral suppression for at least one year.

The researchers collected blood samples before and after sleep deprivation to measure biomarkers of T-cell, monocyte and macrophage activation, cell cycling, T-cell ectoenzyme expression of CD39 and CD73 (markers of adenosine pathway activity) and inflammation markers, including interleukin 6 (IL-6), TNF-alpha, sCD14 and sCD163.

They found that CD8 “killer” T-cell immune activation levels increased significantly after sleep deprivation, though there was no difference in CD4 “helper” T-cell activation. Plasma adenosine levels were similar before and after sleep deprivation, indicating that the compensatory pathway did not kick in.
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