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Author Topic: TIme to switch, Stribild or Triumeq??  (Read 14447 times)

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Offline AaronbytheC

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  • Posts: 124
TIme to switch, Stribild or Triumeq??
« on: December 22, 2014, 12:15:11 am »
So I have been on Atripla for a little over four years now.  For the most part I love it.  Itís easy to take at night as I go to bed and itís constantly kept me UD and CD4ís of 700+.   :) 

However over the past year, slowly but surely brain fog has crept in causing me to feel, well lost and reserved at workÖ  I feel like Iím sleep walking for half of the day, constantly second guessing myself.  My once pleasant vivid dreams have turned dark and confrontational.  I wake up a few times a night, my heart racing and fighting mad from these dreams.  The only way to avoid them is to drug myself up with sleeping pills to sleep through the nightÖ  Of course this just adds to the foggy, groggy feeling in the first half of my morning.   :o

My doc said itís the Sustiva messing with my nervous system and itís time to change.  She suggested Complera, Stribild or Triumeq.  Iíve read as many posts as I can find here on all three but since they are newer combos I thought Iíd ask for advice from people who are on one of them but may not have posted their experiences with them.
  • From what Iíve read Complera needs 400+ calories of food.
  • Stribild goes best with some food, but not a big need for 400+ calories.
  • Triumeq, well that one Iím not seeing much on just yet.

So as I said earlier I usually just brush my teeth and pop an Atripla and head off to bed.  This has work really well for me and I have not missed a single does in four + years I've been on Atripla.  (Serious, not once!)  Iím thinking the Complera is out for me because the only time I constantly eat 400+ calories is lunchtime which would require me to take drugs to work with me and on the weekendsÖ  I just see this as a recipe for missed doses. 

So that leaves me with Stribild or Triumeq.  Does anyone who is taking one or the other take them at night before bed?  If so do you eat a little something, say a granola bar or a yogurt?  Are you happy with the regiment?

Thank you in advance for your responses!

~Aaron
04/2012 CD4 721 / 29% / VL UD
02/2011 UNDETECTABLE!
12/2010 CD4 587 / 24% / VL 210
11/2010 Started Atripla
10/2010 CD4 420 / 18% / VL 13,500
09/2010 CD4 541 / 17% / VL 10,500
08/2010 CD4 498 / 18% / VL Not Taken
07/2010 CD4 307 / 18% / VL 9,500
06/2010 Confirmed Poz
03/2010 Infected
06/2009 Neg

Offline buginme2

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  • Posts: 3,426
Re: TIme to switch, Stribild or Triumeq??
« Reply #1 on: December 22, 2014, 02:57:45 am »
I've been on Atripla, Complera, and now Triumeq.

I really got into a groove with Atripla taking it at night, as you are.  When I switched to Complera I had a hard time adjusting.  The meal requirement was an impediment for me.  I could no longer take it at night and since I work with an often times unpredictable schedule taking the med at a full meal became an issue.  I ended up actually hating my meds.  I developed "pill fatigue."  I would skip Complera if you feel you would be in the same boat.  As far as side effects go.  Complera was a thousand times better than Atripla.  All the negatives of Atripla were erased immediately.  The only bad side effect of Complera is it gave me gas sometimes (the bigger the meal the less gas...just FYI).

I switched to Triumeq.  1.  If you do switch you need the HLA-b test first. 

I take some other meds for non-HIV things and I take those first thing in the morning as soon as I wake up.  I now take my triumeq with it.  You can take it with food or without.  I take it with my morning coffee and whatever breakfast I have (even no breakfast on some days).  There are no side effects.  I adjusted to it immediately and no longer miss taking it at night. 

I've never taken Stribild so I can't comment on that.

PS.  I think your post is a rather common occurrence.  I could have written it.  I feel like I've experienced everything you wrote.



« Last Edit: December 22, 2014, 03:00:21 am by buginme2 »
Don't be fancy, just get dancey

Offline AaronbytheC

  • Member
  • Posts: 124
Re: TIme to switch, Stribild or Triumeq??
« Reply #2 on: December 22, 2014, 05:23:54 pm »
Thanks for your input, I'm getting tested tomorrow for the gene conflict Triumeq can have. 

Any reason you are taking it in the morning rather than at night? 
04/2012 CD4 721 / 29% / VL UD
02/2011 UNDETECTABLE!
12/2010 CD4 587 / 24% / VL 210
11/2010 Started Atripla
10/2010 CD4 420 / 18% / VL 13,500
09/2010 CD4 541 / 17% / VL 10,500
08/2010 CD4 498 / 18% / VL Not Taken
07/2010 CD4 307 / 18% / VL 9,500
06/2010 Confirmed Poz
03/2010 Infected
06/2009 Neg

Offline buginme2

  • Member
  • Posts: 3,426
Re: TIme to switch, Stribild or Triumeq??
« Reply #3 on: December 22, 2014, 06:50:33 pm »


Any reason you are taking it in the morning rather than at night?

It's easy. Wake up, take my pills, have coffee, bite to eat, out the door.  I don't have to worry about meds or pills or anything for the rest of the day.  It turned out to be better than taking it at night.

Don't be fancy, just get dancey

Offline madeindetroit

  • Member
  • Posts: 95
Re: TIme to switch, Stribild or Triumeq??
« Reply #4 on: December 22, 2014, 11:01:02 pm »
I'm on stribild and take them with lunch.  I have a phone app that works well to remind me to take my pill.  Medisafe...its free.  I haven't tested the little portion of food issue since I take with lunch...although at first when I was high stressed about my diagnosis a piece of bread with peanut butter was all I ate
7/8/2014 DX
7/2014 CD4  400 VL 88,000
8/8/2014 Started Stribild
9/2014 CD4 590 VL 250
11/2014 CD4 762 VL 183
2/2015 CD4 735 VL UD wooooohooooo
5/2015 CD4 735 VL UD 38%
8/2015 CD4 1018. UD. 42%
11/2015 CD4 1185. UD 45%

Offline Matts

  • Member
  • Posts: 269
Re: TIme to switch, Stribild or Triumeq??
« Reply #5 on: December 23, 2014, 11:07:03 am »
no problems after 6 months of Triumeq. I take it in the evening cause the pill doesnt like supplements. Reportedly they reduce the Tivicay level up to 50% or something like that. On the other hand it is not a problem if U take the pill with a meal.
« Last Edit: December 23, 2014, 11:13:01 am by Matts »
Descovy+Tivicay

Offline AaronbytheC

  • Member
  • Posts: 124
Re: TIme to switch, Stribild or Triumeq??
« Reply #6 on: December 23, 2014, 01:14:32 pm »
no problems after 6 months of Triumeq. I take it in the evening cause the pill doesnt like supplements.

So do you take it at bed time without food? 

Ideally that's what I'd like to do with a new drug, it's worked really well for me with Atripla to just take a pill and got to bed.   :)
04/2012 CD4 721 / 29% / VL UD
02/2011 UNDETECTABLE!
12/2010 CD4 587 / 24% / VL 210
11/2010 Started Atripla
10/2010 CD4 420 / 18% / VL 13,500
09/2010 CD4 541 / 17% / VL 10,500
08/2010 CD4 498 / 18% / VL Not Taken
07/2010 CD4 307 / 18% / VL 9,500
06/2010 Confirmed Poz
03/2010 Infected
06/2009 Neg

Offline AaronbytheC

  • Member
  • Posts: 124
Re: TIme to switch, Stribild or Triumeq??
« Reply #7 on: December 23, 2014, 01:23:27 pm »
I'm on stribild and take them with lunch.  I have a phone app that works well to remind me to take my pill.

How do you manage to make sure you have meds with you every day at lunch? 

Remembering to take my meds would probably not be my problem...  Access to them would be.   ???  My work schedule has me here, there and everywhere so I'd have to carry one on me at all times rather than a nice little weekly pill box next to my tooth brush with one pill in each slot.
04/2012 CD4 721 / 29% / VL UD
02/2011 UNDETECTABLE!
12/2010 CD4 587 / 24% / VL 210
11/2010 Started Atripla
10/2010 CD4 420 / 18% / VL 13,500
09/2010 CD4 541 / 17% / VL 10,500
08/2010 CD4 498 / 18% / VL Not Taken
07/2010 CD4 307 / 18% / VL 9,500
06/2010 Confirmed Poz
03/2010 Infected
06/2009 Neg

Offline madeindetroit

  • Member
  • Posts: 95
Re: TIme to switch, Stribild or Triumeq??
« Reply #8 on: December 23, 2014, 04:09:09 pm »
I have a pill box that I fill on Sundays....from that if I'm not going to be near my pill box i put a pill into a water proof pocket pill bullet that I carry on my key ring.  When the phone app rattles its time to eat and pill.   Luckily I have an office job that makes it easier....but weekends that little pocket pill fob does wonders
7/8/2014 DX
7/2014 CD4  400 VL 88,000
8/8/2014 Started Stribild
9/2014 CD4 590 VL 250
11/2014 CD4 762 VL 183
2/2015 CD4 735 VL UD wooooohooooo
5/2015 CD4 735 VL UD 38%
8/2015 CD4 1018. UD. 42%
11/2015 CD4 1185. UD 45%

Offline madeindetroit

  • Member
  • Posts: 95
Re: TIme to switch, Stribild or Triumeq??
« Reply #9 on: December 23, 2014, 04:16:26 pm »
My breakfast and dinner times are all over the place for me so my most consistant meal is a 130ish lunch....that's why lunch works for me.  When I started taking pills what i thought take the same time everyday meant just that with no variation whatsoever or I would die LOL.  Now that I have relaxed a bit my lunch time is consistant enough to take the pill on a "scheduled time"
7/8/2014 DX
7/2014 CD4  400 VL 88,000
8/8/2014 Started Stribild
9/2014 CD4 590 VL 250
11/2014 CD4 762 VL 183
2/2015 CD4 735 VL UD wooooohooooo
5/2015 CD4 735 VL UD 38%
8/2015 CD4 1018. UD. 42%
11/2015 CD4 1185. UD 45%

Offline xrel0aded

  • Member
  • Posts: 39
Re: TIme to switch, Stribild or Triumeq??
« Reply #10 on: December 23, 2014, 11:05:53 pm »
I was treatment naive before I started Triumeq two months ago. The first couple days were alright, then after that I experience terrible panic attacks/anxiety, sweaty palms, extreme joint pain, nervousness, shortness of breath, and this annoying sense of impending doom. Most of the symptoms have since subsided, though I still get weird random panic attacks and my hands are really sweaty and shaky most of the day. I attribute it to the Triumeq just because I never had a single symptom such as this before taking it. Who knows, it could be something else though.

Offline drewm

  • Member
  • Posts: 1,246
Re: TIme to switch, Stribild or Triumeq??
« Reply #11 on: December 23, 2014, 11:12:04 pm »
Just switched from Atripla to Triumeq within the last couple of weeks. No noticeable side affects just waiting on first labs.
Diagnosed in  May of 2010 with teh AIDS.

PCP Pneumonia . CD4 8 . VL 500,000

TRIUMEQ - VALTREX -  FLUOXETINE - FENOFIBRATE - PRAVASTATIN - CIALIS


Numbers consistent since 12/2010 - VL has remained undetectable and CD4 is anywhere from 275-325

Offline ChavinKnight

  • Member
  • Posts: 36
Re: TIme to switch, Stribild or Triumeq??
« Reply #12 on: December 23, 2014, 11:46:48 pm »
Hi Aaron,

I've been on Stribild for just over a year.  It is the only medication I've ever taken so I have nothing to compare it to....I take it every evening plus or minus an hour.  If I've eaten in the last hour, I call it good, or if I feel like it, I'll have half a sandwich or something.  Eating is not a huge deal from what I can gather, you just want something in stomach.  My doctor says it has a long enough half life that it is forgiving of flexible administration windows.  As an aside the UK guidelines that I've seen say if you miss a dose, you should still take it up to 18 hours later, otherwise wait for next dose.  In the beginning, I had some fatigue in the afternoon.  Dreams come and go, but nothing unpleasant, but sometimes vivid and intense.  Not sure if that is the medication though, since I've been an intense dreamer my whole life.  I'm satisfied with it.  Easy to take, no real serious side effects yet .... Hope this helps.


Offline AaronbytheC

  • Member
  • Posts: 124
Re: Time to switch, Stribild or Triumeq??
« Reply #13 on: December 24, 2014, 06:32:33 pm »
Thank you all for your input!  Please keep it coming, all of your experiences are helpful to me as well as any future readers of this thread in the same situation.  :)

I had a blood draw yesterday for the gene test for Triumeq...  I thought it was going to be just a little finger prick but they took four tubes out of me!  :o  Maybe I should have asked what this test cost before agreeing to it!  LOL
04/2012 CD4 721 / 29% / VL UD
02/2011 UNDETECTABLE!
12/2010 CD4 587 / 24% / VL 210
11/2010 Started Atripla
10/2010 CD4 420 / 18% / VL 13,500
09/2010 CD4 541 / 17% / VL 10,500
08/2010 CD4 498 / 18% / VL Not Taken
07/2010 CD4 307 / 18% / VL 9,500
06/2010 Confirmed Poz
03/2010 Infected
06/2009 Neg

Offline bmancanfly

  • Member
  • Posts: 783
  • Medicare For All !
Re: TIme to switch, Stribild or Triumeq??
« Reply #14 on: December 26, 2014, 10:02:47 am »
You are currently on three drugs,  Sustiva, tenofovir, and emtricitabine.   The combo of tenofovir and emtricitabine is known as Truvada.  So you are on Sustiva and Truvada.

Most probably the cause of the issues you are having are caused by the Sustiva.  You could just switch out the Sustiva and replace it with Tivicay (or an NNRTI) and keep the Truvada portion.  Less med changes,  less chances of a new side effect.

Triumeq is Tivicay combined with Epzicom (that means three new drugs for you).   If you combined the Tivicay with Truvada you would only be changing out the portion of your current regimen (Sustiva) that is actually causing you the problem.   

Tivicay was combined with Epzicom as a marketing decision.  It is not necessarily the most efficacious combination.  Truvada has a slightly better efficacy than Epzicom and the jury is still out on the cardio vascular risk with Epzicom.

You will have to take two pills once a day with Tivicay and Truvada,  instead one one pill once a day with Triumeq but that doesn't seem to me to be that big of a deal to me.  You,  and your doctor, may decide differently.

Limiting yourself to only "one pill" options may not be in your best interest.  Pill count mattered when people had to take ten or twenty pills a day,  not one or two.

I don't want to lead you to believe that there is a huge difference between Epzicom and Truvada,  but there is a difference.  I wouldn't overlook that difference simply for "pill count" .

Either way I'm sure you'll do well.

Best of luck.







"The trouble with the world is that the stupid are cocksure and the intelligent are full of doubt."

 Bertrand Russell

Offline vertigo

  • Member
  • Posts: 205
Re: TIme to switch, Stribild or Triumeq??
« Reply #15 on: December 26, 2014, 06:18:14 pm »
Let me second the endorsement for Truvada+Tivicay.  It's two pills, but only once a day so no big deal.  No food requirement.  Everything bmancanfly just said is totally on point.

Offline GoForIt

  • Member
  • Posts: 214
Re: TIme to switch, Stribild or Triumeq??
« Reply #16 on: December 28, 2014, 09:32:16 am »
+1 Truvada/Tivicay
08/09/2013  Diagnosed WB positive
08/20/2013  CD4-506(28%)  VL-10,800
09/12/2013  CD4-391(28%)  VL-14,900
09/17/2013  Start ART (Truvada + Tivicay)
10/11/2013  CD4-377(26%)  VL-UD
12/20/2013  CD4-590(??%)  VL-UD
03/18/2014  CD4-660(29%)  VL-UD
07/22/2014  CD4-613(29%)  VL-UD
08/01/2014   Start Phase 3 TAF (Truvada 2.0) Clinical Trial (TAF + Tivicay)
10/09/2014  CD4-498(29.5%) VL-UD
11/06/2014  CD4-600(30.2%) VL-UD
01/30/2015  CD4-529(31.3%) VL-UD
07/25/2015  CD4-742(36.5%) VL-UD
10/06/2015  CD4-765(28.9%) VL-UD
01/05/2016  CD4-907(33.1%) VL-UD
03/24/2016  CD4-770(33.5%) VL-UD
06/20/2016  CD4-850(35.4%) VL-UD

Dr. Mark Wainberg on Dolutegravir:
Video 1: https://youtu.be/wCXOgLJqJAY
Video 2: https://youtu.be/DKiaD7fHO-s

Offline AaronbytheC

  • Member
  • Posts: 124
Re: TIme to switch, Stribild or Triumeq??
« Reply #17 on: December 29, 2014, 12:43:01 pm »
Thanks for the input, something more to think about. 
Question though: Wouldn't two pills require two copays? 
I guess I'll have to talk to my insurance about that one.

Totally off the subject but I learned a hard lesson this year about ADAP...  If you marry your partner they add both of your incomes and then divide it in half.  In my case my husband makes too much money so they assume I make over $50K a year.
 
All I have to say to that is "He married me, not my pet virus!"   >:( 
It's not his responsibility to cover my meds...
04/2012 CD4 721 / 29% / VL UD
02/2011 UNDETECTABLE!
12/2010 CD4 587 / 24% / VL 210
11/2010 Started Atripla
10/2010 CD4 420 / 18% / VL 13,500
09/2010 CD4 541 / 17% / VL 10,500
08/2010 CD4 498 / 18% / VL Not Taken
07/2010 CD4 307 / 18% / VL 9,500
06/2010 Confirmed Poz
03/2010 Infected
06/2009 Neg

Offline buginme2

  • Member
  • Posts: 3,426
Re: TIme to switch, Stribild or Triumeq??
« Reply #18 on: December 29, 2014, 12:48:27 pm »
How much is your Copay?

They both have Copay cards
Don't be fancy, just get dancey

Offline Niceguy2013

  • Member
  • Posts: 74
Re: TIme to switch, Stribild or Triumeq??
« Reply #19 on: January 18, 2015, 09:28:30 pm »
Anyone have info on the cost and coverage of the HLA-B*5701 test for Triumeq? I'm interested in discussing a switch from Atripla on my next appointment, but I've depleted most of my HRA funds.   

 


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