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Author Topic: Drugs That Should Not Be Used With PI or NNRTI Antiretrovirals  (Read 13831 times)

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Offline gerry

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  • Posts: 522
  • Joined AM Feb 2003
Drugs That Should Not Be Used With PI or NNRTI Antiretrovirals
« on: June 03, 2006, 06:13:39 pm »
This is from the DHHS Treatment Guidelines.  It is not meant to be exhaustive; there are a lot more drug interactions that need to be considered in addition to what's listed here.  Some meds that are uncommonly used or are no longer available in the US have been removed.  For more details on individual drugs, check out the drugs section of this website...

Table 20. Drugs That Should Not Be Used With PI or NNRTI Antiretrovirals

PIs

ALL protease inhibitors     Cholesterol lowering drugs:    simvastatin (Zocor, Vytorin), lovastatin (Mevacor)
Sedatives:triazolam (Halcion), midazolam (Versed)
Migraine meds:ergotamine (Cafergot)
TB drugs:rifampin; rifapentine
Supplements:St. John’s wort

In addition, individual PIs that have other specific “do not use with” warnings:

Atazanavir (Reyataz)Acid reflux/ulcer drugs:     esomeprazole (Nexium), lansoprazole (Prevacid, Prevpac) omeprazole (Prilosec); pantoprazole (Protonix), rabeprazole (Aciphex)
Other ARVs:indinavir (Crixivan)
Fosamprenavir (Lexiva)Oral contraceptives
Other ARVs:delavirdine (Rescriptor)
Indinavir (Crixivan)Heart meds:amiodarone (Cordarone)
Other ARVs:atazanavir (Reyataz)
Liponavir/ritonavir (Kaletra)   Heart meds:flecainide (Tambocor), propafenone (Rythmol)
Asthma/allergy meds:fluticasone (Flonase, Flovent, Advair)
Ritonavir (Norvir)Heart meds:amiodarone (Cordarone), flecainide (Tambocor), propafenone (Rythmol), quinidine
Asthma/allergy meds:fluticasone (Flonase, Flovent, Advair)
Saquinavir (Invirase)Supplements:garlic supplements
Tipranavir (Aptivus)Heart meds:amiodarone (Cordarone), flecainide (Tambocor), propafenone (Rythmol), quinidine

NNRTIs

Delavirdine (Rescriptor)   Cholesterol lowering drugs:    simvastatin (Zocor, Vytorin), lovastatin (Mevacor)
Acid reflux/ulcer drugs:esomeprazole (Nexium), lansoprazole (Prevacid, Prevpac) omeprazole (Prilosec); pantoprazole (Protonix), rabeprazole (Aciphex)
Acid reflux/ulcer drugs:cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), ranitidine (Zantac)
Sedatives:alprazolam (Xanax), triazolam (Halcion), midazolam (Versed)
Migraine meds:ergotamine (Cafergot)
TB drugs:rifabutin, rifampin, rifapentine
Anti-seizure meds:carbamazepine (Tegretol), Phenobarbital, phenytoin (Dilantin)
Other ARVs:fosamprenavir (Lexiva)
Supplements:St. John’s wort
Efavirenz (Sustiva)Sedatives:triazolam (Halcion), midazolam (Versed)
Migraine meds:ergotamine (Cafergot)
TB drugs:rifapentine
Supplements:St. John’s wort
Nevirapine (Viramune)TB drugs:rifampin, rifapentine
Supplements:St. John’s wort
« Last Edit: June 03, 2006, 07:08:52 pm by gerry »
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Offline newt

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  • Posts: 3,900
  • the one and original newt
Re: Drugs That Should Not Be Used With PI or NNRTI Antiretrovirals
« Reply #1 on: June 03, 2006, 06:25:14 pm »
Very helpful.

University of Liverpool's Dept of Pharmacology drug interaction websit is also good for checking interactions, but you need to know generic drug names and drug classes - gives you key info from studies though.

The Body's pages of drug interactions details interactions by drug name, including recreational drugs.

- matt

Now playing - Gone : the inestimable Kanye ("Maybe you could be my intern" ha!)
« Last Edit: May 08, 2019, 09:46:44 am by iana5252 »
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"The object is to be a well patient, not a good patient"

Offline J.R.E.

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  • Posts: 8,207
  • Positive since 1985, joined forums 12/03
Re: Drugs That Should Not Be Used With PI or NNRTI Antiretrovirals
« Reply #2 on: June 03, 2006, 08:05:59 pm »
Gerry,

 Thanks for posting the current DHHs treatment guidelines.( link for PDF) I had downloaded it the other week, when it came out, but lost it, when I had reformatted my computer. Good to have it back again.


 Ray
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Current Meds ; Viramune / Epzicom Eliquis, Diltiazem. Pravastatin 80mg, Ezetimibe. UPDATED 2/18/24
 Tested positive in 1985,.. In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started on  HAART on October 24th, 2003.

 UPDATED: As of April, 2nd 2024,Viral load Undetectable.
CD 4 @593 /  CD4 % @ 18 %

Lymphocytes,total-3305 (within range)

cd4/cd8 ratio -0.31

cd8 %-57

72 YEARS YOUNG
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