Meds, Mind, Body & Benefits > Questions About Treatment & Side Effects

Fluconazole/Itraconazole: can these drugs be interchanged? (repost)


Topic Title Can these drugs be interchanged?

Date Posted: Tuesday April 04, 2006 6:33 PM
Posted By: sweetieweasel

I need to know if Fluconazole can be substituted for Itraconazole. Are the compounds similar enough to be interchangeable?

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Lisa - Weasel Guardian


Date Posted: Tuesday April 04, 2006 9:09 PM
Posted By: gerry

No, they are not interchangeable. The indications (i.e., specific fungal infections being treated) for use for each one differs. There is a little overlap, but this will depend on the clinical scenario. Also, there are more potential drug interactions to watch out for with itraconazole.


Date Posted: Friday April 07, 2006 10:04 AM
Posted By: rxzone

Both Fluconazole and Itraconazole are used for fungal infection, however Itraconazole
is more toxic. In general it depends on the condition being treated. Itraconazole can be substituted in case of
patients compromised by the increasing incidence of Aspergillus and certain fluconazole-resistant Candida infections.

Check this link for more info.

Robert Saidov
Registered Pharmacist of



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