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Drugs That Should Not Be Used With PI or NNRTI Antiretrovirals


This is from the DHHS Treatment Guidelines.  It is not meant to be exhaustive; there are a lot more drug interactions that need to be considered in addition to what's listed here.  Some meds that are uncommonly used or are no longer available in the US have been removed.  For more details on individual drugs, check out the drugs section of this website...

Table 20. Drugs That Should Not Be Used With PI or NNRTI Antiretrovirals


ALL protease inhibitors     Cholesterol lowering drugs:    simvastatin (Zocor, Vytorin), lovastatin (Mevacor) Sedatives:triazolam (Halcion), midazolam (Versed) Migraine meds:ergotamine (Cafergot) TB drugs:rifampin; rifapentine Supplements:St. Johnís wort
In addition, individual PIs that have other specific ďdo not use withĒ warnings:

Atazanavir (Reyataz)Acid reflux/ulcer drugs:     esomeprazole (Nexium), lansoprazole (Prevacid, Prevpac) omeprazole (Prilosec); pantoprazole (Protonix), rabeprazole (Aciphex) Other ARVs:indinavir (Crixivan)Fosamprenavir (Lexiva)Oral contraceptives Other ARVs:delavirdine (Rescriptor)Indinavir (Crixivan)Heart meds:amiodarone (Cordarone) Other ARVs:atazanavir (Reyataz)Liponavir/ritonavir (Kaletra)   Heart meds:flecainide (Tambocor), propafenone (Rythmol) Asthma/allergy meds:fluticasone (Flonase, Flovent, Advair)Ritonavir (Norvir)Heart meds:amiodarone (Cordarone), flecainide (Tambocor), propafenone (Rythmol), quinidine Asthma/allergy meds:fluticasone (Flonase, Flovent, Advair)Saquinavir (Invirase)Supplements:garlic supplementsTipranavir (Aptivus)Heart meds:amiodarone (Cordarone), flecainide (Tambocor), propafenone (Rythmol), quinidine

Delavirdine (Rescriptor)   Cholesterol lowering drugs:    simvastatin (Zocor, Vytorin), lovastatin (Mevacor) Acid reflux/ulcer drugs:esomeprazole (Nexium), lansoprazole (Prevacid, Prevpac) omeprazole (Prilosec); pantoprazole (Protonix), rabeprazole (Aciphex) Acid reflux/ulcer drugs:cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), ranitidine (Zantac) Sedatives:alprazolam (Xanax), triazolam (Halcion), midazolam (Versed) Migraine meds:ergotamine (Cafergot) TB drugs:rifabutin, rifampin, rifapentine Anti-seizure meds:carbamazepine (Tegretol), Phenobarbital, phenytoin (Dilantin) Other ARVs:fosamprenavir (Lexiva) Supplements:St. Johnís wortEfavirenz (Sustiva)Sedatives:triazolam (Halcion), midazolam (Versed) Migraine meds:ergotamine (Cafergot) TB drugs:rifapentine Supplements:St. Johnís wortNevirapine (Viramune)TB drugs:rifampin, rifapentine Supplements:St. Johnís wort

Very helpful.

University of Liverpool's Dept of Pharmacology drug interaction websit is also good for checking interactions, but you need to know generic drug names and drug classes - gives you key info from studies though.

The Body's pages of drug interactions details interactions by drug name, including recreational drugs.

- matt

Now playing - Gone : the inestimable Kanye ("Maybe you could be my intern" ha!)


 Thanks for posting the current DHHs treatment guidelines.( link for PDF) I had downloaded it the other week, when it came out, but lost it, when I had reformatted my computer. Good to have it back again.



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