Meds, Mind, Body & Benefits > Questions About Treatment & Side Effects

Short-Cycle Therapy (5 days on/2 days off

(1/2) > >>

testii28:
Hello,

it has been a while that I didn't post anything.
I have been on therapy for about 3 months (Biktarvy).
VL: 57  CD4 approx. 500-600
My kidney values have dropped significantly.
GFR: 73 Creatinine :1,20
 
My doctor refused to change the therapy. There are not much alternatives (doctors) here where I am living. I think this TAF stuff inside Biktarvy cause the kidney issue.

Does anybody has experience with Short-Cycle Therapy (5 days on/2 days off).
Is it worth a try?
https://academic.oup.com/jac/article-abstract/77/3/747/6445130?redirectedFrom=fulltext

https://www.youtube.com/watch?v=0IrqHsak_7M

Thanks for your support.

Jim Allen:

--- Quote ---GFR: 73 Creatinine :1,20
--- End quote ---

It sounds okayish, at least if it were my results within 3 months I would not be too worried myself, I would drink more and monitor this but give it all some time to settle.


--- Quote ---My doctor refused to change the therapy.
--- End quote ---

I am interested if you don't mind sharing; when you say the doctor refused, did they give a reason or context for it?


--- Quote ---Does anybody has experience with Short-Cycle Therapy (5 days on/2 days off).
Is it worth a try?
--- End quote ---

Well, the link is for the rilpivirine combination four days on/three days off therapy. Are you considering this, and do you have access to these meds? I would urge caution given the extremely small sample size.

There are a couple of threads that may help get some background info on other FOTO (Five-On, Two-Off) or short schedules, as the concept isn't new, with some good results and mixed results.

Can HIV Treatment Be Taken Just 4 Days a Week?
https://forums.poz.com/index.php?topic=75216.msg

French study only taking ART 4 days a week
http://i-base.info/htb/36517

FOTO: https://www.poz.com/article/hiv-efavirenz-intermittent-16959-8019

Thread:
Every Other Day: https://forums.poz.com/index.php?topic=72189.msg

Thread: Newer HIV Regimens May Require Less Strict Adherence
https://forums.poz.com/index.php?topic=73003.0

Thread: Fours days a week
https://forums.poz.com/index.php?topic=72799.msg
https://forums.poz.com/index.php?topic=75216.msg


--- Quote ---My doctor refused to change the therapy.
--- End quote ---

Have you looked into what other "mainstream" (approved) treatment options are available in your region? 

testii28:
Thanks for this great information's. The doctor didn't give any reason he just said NO and I had to leave. He gave me the feeling that I should be happy to be alive and get treated. >:(
I just want to get rid off this TAF stuff. Dovato, Juluca, and Triumeq is here not available. It is important for me that my therapy includes an Integrase-inhibitor.

Jim, do you think it is a good idea to continue Biktarvy for the next 3 months until my VL is hopefully fully suppressed  and switching then to 5 days on/2 days off? Worth a try? As far as i read in the links you have given developing resistance should not be an issue.

This kidney thing makes me worry because I also have slight pain and I urinate more than usual.

Jim Allen:

--- Quote from: testii28 on September 14, 2022, 01:35:13 am ---Jim, do you think it is a good idea to continue Biktarvy for the next 3 months until my VL is hopefully fully suppressed  and switching then to 5 days on/2 days off? Worth a try? As far as i read in the links you have given developing resistance should not be an issue.

This kidney thing makes me worry because I also have slight pain and I urinate more than usual.

--- End quote ---

Look, I'm not even sure why you want to do FOTO, doesn't even matter, as for what I think, nobody cares but, no, I would not recommend anyone start FOTO schedule on their own and certainly not with Biktarvy.

You mention there are not many treatment options where you are, I don't know what is available in your region, I would need to check. But if true and it was me, I would be even more hesitant to mess about.

If it were me, I would see what the kidney function is next time round, and if it's similar levels or improved by then, as you are still settling into treatment; happy days. If it gets dramatically worse, I would have another discussion with the doctor about what alternative treatments are available and to check if there are no underlying conditions.

But that's just me, it's your life, choice and HIV treatment.

Jim Allen:

--- Quote ---I also have slight pain and I urinate more than usual.
--- End quote ---

Sorry to hear about the pain, pain when pissing? Might be worth seeing a regular GP

Navigation

[0] Message Index

[#] Next page

Go to full version