Quadruple strength flu vaccine needed for people who are positive

[buginme2]

http://www.medscape.com/viewarticle/776995?src=nl_topic

Researches at the Univ of PA studied the effects of the flu vaccine on HIV positive people and determined that those who received quadruple the normal dose had a better response than those who received the normal dose.

Guess that explains why I got the flu this yeat.

[Buckmark]

http://www.medscape.com/viewarticle/776995?src=nl_topic

Researches at the Univ of PA studied the effects of the flu vaccine on HIV positive people and determined that those who received quadruple the normal dose had a better response than those who received the normal dose.

Guess that explains why I got the flu this yeat.

You can't view this article on Medscape without creating an account.  Care to cut and paste some of the relevant portions of the article here?

[anniebc]

Over the last 10 years I've only ever had the normal dose and have never come down with the flu, I guess some are more suseptable than others to the flu virus, I don't think I will be changing to a higher dose just yet.

Aroha
Jan

[buginme2]

NEWS REFERENCE EDUCATION  MENUMedscape Medical News

Flu Vaccine at Quadruple Dose Needed for Those With HIV

Yael Waknine Jan 02, 2013 A quadruple-dose vaccine may be the answer for protecting patients with HIV from seasonal influenza, according to results from a study published in the January 2013 issue of the Annals of Internal Medicine.

For the study, Noah McKittrick, MD, and colleagues from the University of Pennsylvania and Drexel University in Philadelphia, randomly assigned 190 HIV-positive adults receiving stable antiretroviral therapy to receive either a standard dose (15 μg/strain) or a high dose (60 μg/strain) of trivalent influenza vaccine.

Results at 21 days revealed that for H1N1, the high-dose influenza vaccine yielded a significantly increased antibody response relative to baseline compared with the standard-dose injection (day 21: geometric mean titre [GMT] ratio, 2.0; 95% confidence interval [CI], 1.2 - 3.3 vs baseline: GMT ratio, 1.1; 95% CI, 0.4 - 1.8; P = .008), H3N2 (day 21: GMT ratio, 2.3; 95% CI, 1.4 - 3.7 vs baseline: GMT ratio, 1.0; 95% CI, 0.5 - 1.8; P = .001), and influenza B (day 21: GMT ratio, 2.2; 95% CI, 1.4 - 3.3 vs baseline: GMT ratio, 1.2; 95% CI, 0.5 - 1.4; P< .001)

.A similar effect was observed with respect to seroconversion rates and seroprotection rates for H1N1 (75% vs 59% [ P = .018] and 96% vs 87% [ P = .029] for high dose and standard dose, respectively), H3N2 (78% vs 74% [ P = .50] and 96% vs 92% [ P = .32] for high dose and standard dose, respectively), and influenza B (56% vs 34% [P = .003] and 91% vs 80% [ P = .030] for high dose and standard dose, respectively).

 Both vaccines were equally well-tolerated, though pain was more often reported with the high-dose version (15% vs 4%).The researchers acknowledge the main limitation of their study, which mirrors other influenza vaccine trials in those who are immunosuppressed; namely, that serologic response was measured rather than the incidence of clinical influenza. The latter would require a much larger sample size.In addition, "[the] high baseline seropositivity rate may have contributed to the very high seroprotection rate at the end of our study," the authors note, attributing the high (50%) proportion of participants with protective titers at baseline to the increased rate of vaccination associated with the 2009-2010 pandemic and the fact that patients with HIV are more frequently engaged in care than other underserved populations."

The implications of this research are important for future vaccination efforts in the HIV-positive population," the authors conclude, noting that although a single high-dose immunization strategy is much easier to implement than multiple-dose schedules, further study may yield additional options such as alternative vaccines, use of adjuvants, or new schedule strategies.The study was supported by grants from the National Institute of Allergy and Infectious Diseases and the Center for AIDS Research to the University of Pennsylvania. Dr. McKittrick has disclosed no other relevant financial relationships. Full conflict-of-interest information is available on the journal's Web site.Ann Intern Med. 2013;158:19-26. Abstract Latest in HIV/AIDSFDA Approves First Antidiarrheal Drug for HIV/AIDSHIV and Smoking May Be a Deadly CombinationHIV Cases Down for Black Women, Up for Gay Men: CDCGuidelines Target HIV-Associated Neurocognitive DeficitsStavudine Toxicity in Children May Be Exaggerated: StudyMedscape Medical News © 2013  WebMD, LLC Send comments and news tips to news@medscape.net.Cite this article: Flu Vaccine at Quadruple Dose Needed for Those With HIV.  Medscape. Jan 02, 2013.About MedscapePrivacy PolicyTerms of UseWebMDMedicineNeteMedicineHealthRxListWebMD CorporateHelpContact UsLog OutAll material on this website is protected by copyright, Copyright © 1994-2013 by WebMD LLC. This website also contains material copyrighted by 3rd parties.

[Miss Philicia]

I can personally attest that the campus of Univ of PA has many hot men. And if Wumpy ever finds himself there he should include this in his stop.