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Author Topic: Starting treatment early = smaller viral reservoir  (Read 4374 times)

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Offline Jim Allen

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Starting treatment early = smaller viral reservoir
« on: July 11, 2022, 05:32:48 am »
Another study indicates that starting treatment early means greater odds of a smaller viral reservoir.

https://www.poz.com/article/people-start-hiv-treatment-early-smaller-viral-reservoir

Quote
People with HIV who started antiretroviral treatment early, before their CD4 T-cell count fell below 800, had a substantially smaller viral reservoir, according to study findings published in Clinical Infectious Diseases. Having a smaller reservoir of latently infected CD4 cells improves the prospects for long-term remission.

The study included 149 people with HIV in Peru, South Africa and Uganda who participated in the Strategic Timing of Antiretroviral Treatment (START) trial. In 2015, this trial confirmed that starting treatment early leads to better outcomes than waiting until a person’s CD4 count falls below 350, which was previously used as a threshold for starting ART in an effort to reduce side effects. Today, guidelines recommend treatment initiation as soon as possible after HIV diagnosis.
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Offline Da2020

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Re: Starting treatment early = smaller viral reservoir
« Reply #1 on: July 17, 2022, 10:18:43 pm »
How do they even measure this reservoir? Is there a lab test we could order or is is only done as part of a clinical study?
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Offline Jim Allen

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Re: Starting treatment early = smaller viral reservoir
« Reply #2 on: July 18, 2022, 12:03:52 pm »
https://pubmed.ncbi.nlm.nih.gov/29071475/

See the above link.

Not sure why you would want to measure it outside of a study, though. Can't think of any practical use in knowing this.
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