Welcome, Guest. Please login or register.
June 07, 2023, 02:18:57 am

Login with username, password and session length

  • Total Members: 37166
  • Latest: Dan777
  • Total Posts: 769268
  • Total Topics: 65831
  • Online Today: 120
  • Online Ever: 5484
  • (June 18, 2021, 11:15:29 pm)
Users Online
Users: 0
Guests: 76
Total: 76


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Do I Have HIV?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: HIV regimen question  (Read 388 times)

0 Members and 1 Guest are viewing this topic.

Offline christophersf1964

  • Member
  • Posts: 4
HIV regimen question
« on: May 14, 2023, 09:27:28 am »

I've been living with HIV for 20 years. I've been on one treatment regimen since being diagnosed. I remain undetectable and my CD4 count has ranged between 862 and 591 over the last few years.

I began treatment within weeks of being exposed to HIV. I take Reyatez and Epzicom, which consist of three pills once a day. I have had no side effects since I started treatment.

While this regimen is working well, I worry about the cumulative toxicity burden these older drugs are having on my system. I'm thinking about going on a newer treatment regimen with one pill in hopes of mitigating some of this.

Would love to get some thoughts from others on this topic.

Thank you.


Offline Jim Allen

  • Administrator
  • Member
  • Posts: 20,881
  • Twitter @JimAllenDublin
    • HIV Lessons
Re: HIV regimen question
« Reply #1 on: May 14, 2023, 11:11:12 am »

Have you spoken to your healthcare provider about switching already? Did they recommend any particular option?

Unless there is a problem with the labs, I would not change. I have refused to change my current HIV treatment choice for this reason, nothing wrong with it, and there is no benefit for me to change. 

If you do change, you could get newer combinations without the Atazanavir (Reyatez), although many options would still contain Abacavir or lamivudine.  (Epzicom)

Another option would be one pill a day combined with TAF like Biktarvy (Bictegravir + emtricitabine + tenofovir alafenamide) Although some people have issues like weight gain.


I'm taking Triumeq (Dolutegravir + Lamivudine + Abacavir), so one pill a day, and I don't need to take it with food; I have no complaints but Dolutegravir isn't everyone's cup of tea. There are also combinations that only use two drugs nowadays, like Dovato (Dolutegravir/Lamivudine )

Your choice would also depend on your other medical needs, your resistance profile, and what could work for you.

Have a look at the drug chat and talk to your doctor.
HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline christophersf1964

  • Member
  • Posts: 4
Re: HIV regimen question
« Reply #2 on: May 14, 2023, 11:32:12 am »
Thanks for sharing your thoughts, Jim.

I have spoken to my physician about changing meds. He's open to letting me switch to one pill a day and suggested Biktarvy.

There are no problems with my labs, and I'm a healthy guy with no other medical problems.

The more I research switching, the more inclined I am to stick with the medication that I'm on. You run the risk of side effects and there's a chance I might be resistant to the new meds.

One other reason I was thinking about changing meds is because of my sleep. I wake up a lot at night and have wondered if it had anything to do with the meds I'm on.


Offline Tonny2

  • Member
  • Posts: 2,692
Re: HIV regimen question
« Reply #3 on: May 14, 2023, 02:50:24 pm »

               ojo.                 Hi Christopher, definitely, you are taking and no regiment. I took Reyataz in 2006, he didnít work for me. I guess itís time to try a new medication, just one pill a day. Biktarvy is good medication, I have lots of friends, taking it without a problem, hopefully you will be happy with the changeÖ wishing you the best and please keep us posted

Offline christophersf1964

  • Member
  • Posts: 4
Re: HIV regimen question
« Reply #4 on: May 14, 2023, 04:06:25 pm »
Thank you, Tonny2.


Offline leatherman

  • Global Moderator
  • Member
  • Posts: 8,231
  • Google and HIV meds are Your Friends
Re: HIV regimen question
« Reply #5 on: May 14, 2023, 07:12:16 pm »
just a pet peeve of mine, but this stigma surrounding HIV meds always gets me.

HIV meds simply stop HIV from replicating. They don't make you lose your hair or destroy parts of your immune system, etc like other meds. Now some of these meds don't always flush through the kidneys well and that can be a problem; but that's really not the med but somebody's kidneys and how their body functions. In cases like that, you just try a different regimen. Reading the package inserts and the FDA approvals, it's easy to see that most people have no long term or short term effects. Some people do have short term effects for a while and only a tiny percentage of patients have long term effects. The end result is that most people have no effects except for the suppression of HIV.

There is really no toxicity with HIV meds. There's just how your body handles or doesn't handle them.

That's why, getting back to your question, my advice as someone who's been taking meds for 3 decades, is if it ain't broke don't fix it. ;)
leatherman (aka Michael)

We were standing all alone
You were leaning in to speak to me
Acting like a mover shaker
Dancing to Madonna then you kissed me
And I think about it all the time
- Darren Hayes, "Chained to You"

Offline christophersf1964

  • Member
  • Posts: 4
Re: HIV regimen question
« Reply #6 on: May 14, 2023, 07:17:46 pm »
Thanks for sharing your perspective, Leatherman.


Offline Grasshopper

  • Member
  • Posts: 731
Re: HIV regimen question
« Reply #7 on: May 14, 2023, 09:41:34 pm »
just a pet peeve of mine, but this stigma surrounding HIV meds always gets me.

That's why, getting back to your question, my advice as someone who's been taking meds for 3 decades, is if it ain't broke don't fix it. ;)

Gets on my nerves too when reading such comments.
Totally agree with your last sentence .

I've been on Biktarvy (without any issues) for the last couple of years. Undetectable since 2001 with excellent CD4 count (mind you coming from a Nadir of 0= zero!)...a bit reluctant to say how many. The "excellent CD4 count" 4 times in a row however was a bit of a concern for my doc's, so I had extra labs done to exclude possible Leukemia. But thank Heavens those came back negative. For years I was hovering around 1300 CD4's, but the last 4 labs I had counts averaging 1900 CD4's.

The pains and aches that I have once in a very while, are age related......Hiv/Aids feels to me like something from a previous life.


Terms of Membership for these forums

© 2023 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.