Therapeutic HIV Vaccine Fails to Stall Viral Rebound

[Jim Allen]

Well that is a shame but at least it was tried and even from the fails we do learn.
Not seeing this as a negative result, just a result that provides a better understanding and also may indicate that prehaps more is needed or an adjusted approach next time round.   

Jim

20th Dec 2017
More on this story here: https://www.poz.com/article/therapeutic-hiv-vaccine-fails-stall-viral-rebound

An experimental HIV vaccine failed to delay viral rebound after a small number of people with HIV were taken off their antiretroviral (ARV) treatment in a recent trial. Nevertheless, the study provided researchers with clues to help in their long-term quest to develop a means of prompting a state of post-ARV-treatment viral remission in HIV-positive individuals.

Publishing their findings in Science Translational Medicine, researchers conducted a randomized, double-blind placebo-controlled clinical trial including people with HIV who started ARVs shortly after contracting the virus.

Fourteen participants were randomized to receive the therapeutic vaccine while 15 others received saline placebo injections. All participants received four injections over a 36-week period during which they remained on their ARVs.

All participants then entered a 16-week analytical treatment interruption during which they stopped taking their ARVs. There was no difference between the two study arms in the time before participants’ virus rebounded, once again becoming detectable.

[CaveyUK]

There's no mention of any of the mechanism of this proposed 'vaccine' but I hope that information is readily available for others researching in this area.

It certainly failed spectacularly, seeming to have no effect whatsoever. In a way it would have been better if it showed modest effects as it would provide more clues.

I'm not sure they will glean anything from the few folk who were able to suppress the virus for longer than others....who were on the placebo....