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Author Topic: Maturation inhibitors?  (Read 4342 times)

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Offline CircularNatural

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Maturation inhibitors?
« on: October 19, 2021, 02:17:15 pm »
As a sidenote, after my diagnosis (Aug 2021) my ID doctor offered me that if I wanted to he could refer me to an experimental trial going on here in Argentina regarding a newer drug belonging to the "Maturation inhibitor" class.
I was really anxious at that time (I needed certainties) so I asked to start treatment with generic Dovato (dolutegravir + lamivudine) instead (which I'm currently happy with, even though I've just started a month and a half ago).

I feel curious about this new class of drugs, though.

Does anybody have any information on maturation inhibitors or newer meds?

Big hugs to all
🇦🇷 "Hope is the only thing stronger than fear."

Offline Jim Allen

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Re: Maturation inhibitors?
« Reply #1 on: October 19, 2021, 02:32:01 pm »
Would that offer have been GSK3640254? There have been a few over the years but I think this one was the most recent.

https://www.poz.com/article/early-studies-hiv-maturation-inhibitor-shows-safe-tolerable (2019) Early Studies of HIV Maturation Inhibitor Shows It’s Safe and Tolerable

https://www.medpagetoday.com/meetingcoverage/croi/91572 (2021)
Maturation Inhibitor Shows Promise for HIV — Encouragement from phase II study, but emergent resistance remains a problem

I don't think off the top of my head there are any Maturation Inhibitor HIV treatments in general use though. Few attempts over the last decade+ I know that, but happy to be corrected though if anyone knows an approved Maturation Inhibitor for HIV treatment?

There is this cheat sheet with a list of treatments.
https://www.poz.com/drug_charts/hiv-medications

Might split this into its own topic, still debating it with myself.

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Offline CircularNatural

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Re: Maturation inhibitors?
« Reply #2 on: October 19, 2021, 02:37:31 pm »
Yeah, that sounds probable (GSK3640254), since the article says that it's for people new to ARVs
It'll be interesting to follow this up :)
🇦🇷 "Hope is the only thing stronger than fear."

Offline CircularNatural

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Re: Maturation inhibitors?
« Reply #3 on: October 19, 2021, 03:10:53 pm »
I'm glad I said no, though, since I also just read that there were reports of drug resistances and that it had to go paired with other 2 NNRTIs, so I'd rather stay with my current Dovato treatment (I haven't had a check-up after starting, though)
🇦🇷 "Hope is the only thing stronger than fear."

Offline Jim Allen

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Re: Maturation inhibitors?
« Reply #4 on: October 20, 2021, 07:43:52 am »
So as a note, I split the above posts into a new topic on "Maturation inhibitors"

The original topic can be found here: https://forums.poz.com/index.php?topic=75669.0 Dolutegravir Trumps Other HIV Meds in Cutting Viral Load
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Offline harleymc

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Re: Maturation inhibitors?
« Reply #5 on: November 04, 2021, 03:36:54 am »
Sometimes I adore having failing eyesight. 


I misread the post title as "masturbation inhibitors"...

 


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