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Meds, Mind, Body & Benefits => Research News & Studies => Topic started by: Jim Allen on June 15, 2022, 10:46:53 am

Title: Engineered B cells in Mice produce broadly neutralizing anti-HIV antibodies
Post by: Jim Allen on June 15, 2022, 10:46:53 am

Early days and we know most of these things don't pan out but an interesting read, although, the media hype around this one is the usual nonsense::)

A study by Dr. Adi Barzel and PhD student Alessio Nehmad used CRISPR gene-editing genetically engineered type B white blood cells (with one coding for Staphylococcus aureus Cas9 (saCas9) and the other for 3BNC117, an anti-HIV bNAb) to produce neutralizing antibodies against HIV in mice and lab dishes.

Abstract:
https://www.nature.com/articles/s41587-022-01328-9

https://www.genengnews.com/virology/hiv/could-a-one-shot-treatment-for-patients-with-hiv-be-on-the-horizon/

In Full: Thanks to genengnews.com.

https://www.nature.com/articles/s41587-022-01328-9.epdf?sharing_token=zmq5yP07hfwhLuRf-WoU79RgN0jAjWel9jnR3ZoTv0O4VgULSyAEQr4OdsIEhFjnxDnQfSzX7Dbd5lWp5IQgafD3BGY2LPeXH_HBB43jKhs2Ml-H4Z6XzKi0bwhZjpaZHpOCw1eNw3_KfL1dwKLXLUiaJwuyiMDnr7B5QTWc2Lhdb2AB_LmvopFeYW2nFclDR5pB_p1g3Wzk1Gou6ZtRmZUVOeTJ5q1r8VxDGrDQ5-M%3D&tracking_referrer=www.genengnews.com

Another study using an anti-HIV-1 antibody for viral suppression was also recently posted:


Viral suppression with anti-HIV-1 antibody - Phase 1b 3BNC117 & 10-1074
https://forums.poz.com/index.php?topic=76091.msg

Title: Re: Engineered B cells in Mice produce broadly neutralizing anti-HIV antibodies
Post by: jeju on June 15, 2022, 10:47:59 am

Quote

Researchers at Tel Aviv University have developed a new and unique treatment method that could possibly be developed into a vaccine or a one-time treatment for HIV/AIDS. The new technique utilizes type B white blood cells that would be genetically engineered inside the patient's body to secrete anti-HIV antibodies in response to the virus.

https://www.thehealthsite.com/news/one-time-treatment-for-hiv-aids-a-single-injection-is-all-that-you-may-need-887252/

Title: Re: Engineered B cells in Mice produce broadly neutralizing anti-HIV antibodies
Post by: Da2020 on June 20, 2022, 10:26:34 am

Can’t agree more with media nonsense. They haven’t even tested it in vivo