Welcome, Guest. Please login or register.
May 28, 2024, 04:00:40 pm

Login with username, password and session length

  • Total Posts: 773605
  • Total Topics: 66391
  • Online Today: 287
  • Online Ever: 5484
  • (June 18, 2021, 11:15:29 pm)
Users Online
Users: 2
Guests: 252
Total: 254


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Do I Have HIV?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: HIV - Distinct reservoir in the brain and spinal cord.  (Read 3832 times)

0 Members and 1 Guest are viewing this topic.

Offline Jim Allen

  • Administrator
  • Member
  • Posts: 22,507
  • Threads: @jim16309
    • Social Media: Threads
HIV - Distinct reservoir in the brain and spinal cord.
« on: February 09, 2023, 08:12:02 am »
Interesting read, although, for some reason, I truly thought this was already known?

POZ.com in full: https://www.poz.com/article/hiv-may-establish-one-viral-reservoir
February 8, 2023 • By Liz Highleyman


HIV may lie dormant in a distinct viral reservoir in the central nervous system (CNS), or brain and spinal cord, which could present an additional barrier to a cure, according to a recent report in Nature Microbiology.

“Our analysis of rebound virus suggests latently infected T cells in the CNS are separate from the latent reservoir in the blood,” senior stud author Ron Swanstrom, PhD, of the University of North Carolina School of Medicine said in a press release. “Our analysis allows us to infer the presence of a distinct pool of latently infected cells in the CNS waiting to reinitiate infection once antiretroviral therapy is interrupted.”

The researchers compared genetic sequences of rebounding virus soon after treatment interruption in the blood and CSF of people living with HIV to determine whether they were part of a common latent viral reservoir.

The analysis included eight men at the University of California San Francisco (UCSF) and two men and one woman at the University of Gotherburg in Sweden. Ages ranged from 39 to 56.

The researchers found that high rebound viral load in the CSF was associated with the transient entry of white blood cells into the CNS—known as pleocytosis—which occurred in about half of the participants after treatment interruption. In some people, viral sequences were not the same in the blood and CSF, suggesting they arose from different populations of latently infected cells.

The authors observed that clonally amplified viral lineages, or virus that originates from cells with a common ancestor, were disproportionately present in the CSF compared with the blood in these individuals (a phenomenon dubbed compartmentalization), suggesting a local source of virus within the central nervous system.

These findings suggest that strategies to cure HIV may need to reach a latent viral reservoir in the brain as well as dormant virus residing in T cells in the blood and lymph system.
HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

My Instagram


Terms of Membership for these forums

© 2024 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.