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Author Topic: Has anybody heard of molecular scissors?  (Read 2282 times)

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Offline Mints22

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Has anybody heard of molecular scissors?
« on: May 24, 2016, 01:28:00 pm »
Hey everybody,
As i am newly diagnosed only a month in and 2 weeks on my triumeq treatment, i have been doing research and read an article online about molecular scissors being used as a cure, here is the article.
http://www.hivequal.org/hiv-equal-online/how-scientists-cut-hiv-out-of-its-hiding-spots-using-molecular-scissors

Im just wondering if anyone has any further knowledge about it or if their doctors have brought up anything up about molecular scissors?
Vl 50000 cd4 162 5/11/16
Triumeq and bactrim started 5/13/16

Offline Jim Allen

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Re: Has anybody heard of molecular scissors?
« Reply #1 on: May 24, 2016, 01:43:30 pm »
Hi

It's just research, not even new and it well, failed in a way but thats okay we even learn from the failures.  At the end of the day no cure or treatment unfortunately just bad/false reporting from the media. Here is the thread on this one: http://forums.poz.com/index.php?topic=62271.0

Media Outlets Falsely Claim That a Cure for HIV May Be Only Three Years Away
https://www.poz.com/article/media-outlets-falsely-claim-cure-hiv-may-three-years-away

Molecular scissors failed.
http://medicalxpress.com/news/2016-04-hiv-resistance-crisprcas9.html

Hang in there and keep taking you meds. You will see a lot of this type of research  come and go just don't get hooked on media headlines.

Hope you are doing okay.

Jim

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Offline CaveyUK

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Re: Has anybody heard of molecular scissors?
« Reply #2 on: May 24, 2016, 01:49:04 pm »
Yep, if you look through the sub-forum you will see references to this elsewhere.

It's good to be rooting for a cure, but if one does come it will likely be many years away as even if they found one tomorrow it would have to undergo years of research and clinical trials before being used.

Research is really important though, and when we do see a failure in the research thats actually a good thing as it contributes to overall knowledge and allows researchers to switch focus onto other techniques.

The thing to also remember is that modern meds can make the virus undetectable in your blood, render you unable to transmit the virus and allow your immune system to recover to normal levels allowing you to live a long and healthy life.

Yes, you are still HIV+ but thats damn near a functional cure on many levels already

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Offline Jim Allen

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Re: Has anybody heard of molecular scissors?
« Reply #3 on: May 24, 2016, 01:56:30 pm »
Look everybody tends to (in my opinion) slightly over do things at first trying to gain knowledge and often this tends to lead people to look for a "cure" and "cure" news.
It's understandable though, your new and trying to get your head around this.
 
Personally I take a pill a day and live my life. That's it.

I think the POZ article is a more fair update on this one. 23rd of May -  Seems like most research, this has given us a better insight into HIV but still no cure and no way near ready for humans, it had some limited success on rats it seems.

https://www.poz.com/article/researchers-use-crispr-edit-hiv-dna-live-animal-cells
Quote
The same researchers reported in March that they had successfully edited HIV DNA out of HIV-infected human cells in a laboratory setting. The paper led to a rash of erroneous media reports, stemming from an article in the United Kingdomís The Guardian, claiming that a cure for HIV was only three years away.
 
Shortly after that paper was published, another research team put out a paper that found that HIV could become resistant to CRISPR/Cas9 gene editing, leading researchers to theorize that a multipronged gene-editing approach would be necessary to prevent such resistance.
 
The researchers in this new study injected the gene-editing apparatus into the rodentsí bloodstreams, and two weeks later analyzed the DNA in tissue samples from the animals. They found that the system had successfully snipped the targeted HIV fragment from more than half the cells of each type, including those in the tissues of the brain, heart, kidney, liver, lungs and spleen and in blood cells.
 
Analyzing the ratsí RNA, the investigators found that the gene editing had significantly lowered levels of viral RNA in circulating lymphocyte immune cells, as well as in the lymph nodes.
Jim
« Last Edit: May 24, 2016, 02:02:05 pm by JimDublin »
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Offline Mints22

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Re: Has anybody heard of molecular scissors?
« Reply #4 on: May 24, 2016, 02:03:46 pm »
I did not realize that there was a sub forum on this, im still learning all the ins and outs of this forum lol. But yeah i agree its better to have a trial and fail than not trying at all. And in all honesty there could be a breakthrough tomorrow(just hypothetically of course) it could take some years. But the fact is that, with the new medicines out and the fact that they allow us to be undetectable and not transmit the virus is crazy(in the best way possible). From my first posts on here having heard stories from long term survivors, as well as newly infected persons, it gives me a lot of hope for the future with this. The major thing to combat is the stigma that has been placed upon it, atleast thats how i feel
Vl 50000 cd4 162 5/11/16
Triumeq and bactrim started 5/13/16

Offline Mints22

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Re: Has anybody heard of molecular scissors?
« Reply #5 on: May 24, 2016, 02:13:25 pm »
I honestly havent been reading up on a cure except for today when my friend said he heard something on the radio about it and i should check it out, thats why i wanted to ask after i read the article about it. But im taking my one pill a day right now and life hasnt changed much, besides my gf leaving, and me taking a pill everyday right now i feel the same. And am very hopeful and positive with the medicine. Once i get to UD and my cd4s come up ill be a little more relaxed since theres still a risk of pep. But im sure everything will be fine. And its really crazy to hear stories of years ago, and then today. Its some very good news to hear
Vl 50000 cd4 162 5/11/16
Triumeq and bactrim started 5/13/16

Offline Jim Allen

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Re: Has anybody heard of molecular scissors?
« Reply #6 on: May 24, 2016, 02:14:32 pm »
Glad to hear your looking at things from a positive (pardon me) point of view. 

I did not realize that there was a sub forum on this, im still learning all the ins and outs of this forum lol.
  Don't worry about it, some people never learn the ins and outs. Most of my day is spent moving stuff around, so your in good company. ;-)

Jim
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