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Meds, Mind, Body & Benefits => Research News & Studies => Topic started by: CircularNatural on October 19, 2021, 02:17:15 pm

Title: Maturation inhibitors?
Post by: CircularNatural on October 19, 2021, 02:17:15 pm

As a sidenote, after my diagnosis (Aug 2021) my ID doctor offered me that if I wanted to he could refer me to an experimental trial going on here in Argentina regarding a newer drug belonging to the "Maturation inhibitor" class.
I was really anxious at that time (I needed certainties) so I asked to start treatment with generic Dovato (dolutegravir + lamivudine) instead (which I'm currently happy with, even though I've just started a month and a half ago).

I feel curious about this new class of drugs, though.

Does anybody have any information on maturation inhibitors or newer meds?

Big hugs to all

Title: Re: Maturation inhibitors?
Post by: Jim Allen on October 19, 2021, 02:32:01 pm

Would that offer have been GSK3640254? There have been a few over the years but I think this one was the most recent.

https://www.poz.com/article/early-studies-hiv-maturation-inhibitor-shows-safe-tolerable (2019) Early Studies of HIV Maturation Inhibitor Shows It’s Safe and Tolerable

https://www.medpagetoday.com/meetingcoverage/croi/91572 (2021)
Maturation Inhibitor Shows Promise for HIV — Encouragement from phase II study, but emergent resistance remains a problem

I don't think off the top of my head there are any Maturation Inhibitor HIV treatments in general use though. Few attempts over the last decade+ I know that, but happy to be corrected though if anyone knows an approved Maturation Inhibitor for HIV treatment?

There is this cheat sheet with a list of treatments.
https://www.poz.com/drug_charts/hiv-medications

Might split this into its own topic, still debating it with myself.

Title: Re: Maturation inhibitors?
Post by: CircularNatural on October 19, 2021, 02:37:31 pm

Yeah, that sounds probable (GSK3640254), since the article says that it's for people new to ARVs
It'll be interesting to follow this up :)

Title: Re: Maturation inhibitors?
Post by: CircularNatural on October 19, 2021, 03:10:53 pm

I'm glad I said no, though, since I also just read that there were reports of drug resistances and that it had to go paired with other 2 NNRTIs, so I'd rather stay with my current Dovato treatment (I haven't had a check-up after starting, though)

Title: Re: Maturation inhibitors?
Post by: Jim Allen on October 20, 2021, 07:43:52 am

So as a note, I split the above posts into a new topic on "Maturation inhibitors"

The original topic can be found here: https://forums.poz.com/index.php?topic=75669.0 Dolutegravir Trumps Other HIV Meds in Cutting Viral Load

Title: Re: Maturation inhibitors?
Post by: harleymc on November 04, 2021, 03:36:54 am

Sometimes I adore having failing eyesight. 


I misread the post title as "masturbation inhibitors"...