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Author Topic: Enochian BioSciences  (Read 3437 times)

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Offline Matts

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Enochian BioSciences
« on: May 16, 2021, 04:13:31 am »
Some news that give some hope. A Longterm Survivor with quite high VL even under ART became undetectable for months. Another "normal" ART patient had the same results.

"Enochian BioSciences announces Scientific Presentation of a Person with HIV Exhibiting Controlled Blood Levels of Virus for 255 Days Following Treatment with a Novel Cellular Therapy


Published: May 12, 2021 

 
LOS ANGELES, May 12, 2021 (GLOBE NEWSWIRE) -- (NASDAQ: ENOB) – Enochian Biopharma, Inc., a company focused on gene-modified cellular and immune therapies in infectious diseases and cancer, today announced the release of preliminary data relating to the use of a novel cell therapy approach in controlling human immunodeficiency virus (HIV) in humans. Dr. Serhat Gumrukçu, co-founder and inventor of Enochian BioSciences and Director of the Seraph Research Institute (SRI), presented the findings at the Annual Meeting of the American Society of Gene and Cell Therapy (ASGCT). Presentation can be found at https://www.enochianbio.com/about-us/collaborations/

A 54-year-old man, diagnosed with HIV in 1986, had persistent HIV detected in his blood, despite antiretroviral therapy. With approval from an Institutional Review Board, this single patient was treated with a novel cellular therapy of natural killer (NK) and gamma delta T-cells (GDT) – a small subset of immune cells that can be infected with HIV but could also be a key factor in controlling the virus. The NK and GDT cells were collected from a person who does not have HIV. Because the patient stopped antiviral treatment and received some supportive medication before the cellular therapy, the level of HIV initially increased, as expected.

However, HIV levels began to decline after approximately three weeks, and after 100 days dropped below the detection level of routinely used blood tests (20 copies/ml). HIV levels in the patient’s blood have remained at or below detection for an additional 255 days, all while the patient has not been taking antiviral medication.

This innovative cell therapy could be a potential strategy to achieve a “functional cure” for HIV. This could potentially allow persons living with HIV to stop antiviral treatment for extended periods of time. Dr. Gumrukçu and SRI are currently pursuing a regulatory pathway with the FDA to study the approach in more patients. Enochian BioSciences holds the exclusive license for the proprietary technology.

Dr. Mark Dybul, a prominent global HIV expert and Executive Vice Chair of Enochian BioSciences said, “As an HIV researcher, clinician and former leader of large, global HIV treatment programs, I am excited by these results. Although antiviral treatment is very effective, it is expensive and some patients cannot, or do not want to receive it. This, combined with the fact that access to antiviral treatments is limited, creates a significant unmet medical need. While the findings presented are preliminary and in one person with HIV, I’m hopeful that with further testing in larger patient populations, SRI’s novel cell therapy approach could one day be an alternative HIV treatment to many.”

https://www.biospace.com/article/releases/enochian-biosciences-announces-scientific-presentation-of-a-person-with-hiv-exhibiting-controlled-blood-levels-of-virus-for-255-days-following-treatment-with-a-novel-cellular-therapy/
« Last Edit: May 16, 2021, 04:31:03 am by Matts »
Biktarvy

Offline nethan1621

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Re: Enochian BioSciences
« Reply #1 on: May 19, 2021, 12:31:16 am »
Problem is nobody wanna kill the golden chicken  :'(

Offline Jim Allen

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Re: Enochian BioSciences
« Reply #2 on: May 19, 2021, 02:10:00 am »
Problem is nobody wanna kill the golden chicken  :'(

 ;D Stop it.

Plenty of novel ideas, long-term treatments or functional cures over the years have just not worked out. No conspiracy in that respect.

Quote
LOS ANGELES, May 12, 2021 (GLOBE NEWSWIRE) -- (NASDAQ: ENOB) – Enochian Biopharma, Inc., a company focused on gene-modified cellular and immune therapies in infectious diseases and cancer, today announced the release of preliminary data relating to the use of a novel cell therapy approach in controlling human immunodeficiency virus (HIV) in humans. Dr. Serhat Gumrukçu, co-founder and inventor of Enochian BioSciences and Director of the Seraph Research Institute (SRI), presented the findings at the Annual Meeting of the American Society of Gene and Cell Therapy (ASGCT). Presentation can be found at https://www.enochianbio.com/about-us/collaborations/

So far so good for the individual person testing this. It's been only 255 days though so would be interesting to see what happens with more time and when they test this with a larger cohort.
« Last Edit: May 19, 2021, 03:00:52 am by Jim Allen »
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Offline nethan1621

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Re: Enochian BioSciences
« Reply #3 on: May 19, 2021, 11:44:00 pm »
 ;D ;D ;D ;D ;D  No more no more

Offline Mightysure

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Re: Enochian BioSciences
« Reply #4 on: May 30, 2021, 10:54:28 am »
Problem is nobody wanna kill the golden chicken  :'(

Except the PhDs and scientists who want recognition for finding the HIV cure. There's nore than big bad pharma out there.

Offline MitchMiller

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Re: Enochian BioSciences
« Reply #5 on: June 21, 2021, 05:50:54 am »
Thought it was interesting that Gilead has partnered with a company that is also reengineering NK cells.  However, Gilead states they will be targeting cancer.  Let's hope they don't try to build a patent wall to block competitors like Enochian.

https://pharmaphorum.com/news/gilead-combs-shoreline-for-nk-cell-therapies-in-2-3bn-alliance/

Offline MitchMiller

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Re: Enochian BioSciences
« Reply #6 on: September 17, 2021, 09:51:24 pm »
In the latest slide deck from Enochian BioScience's recent corporate presentation, they state that the test subject is still undetectable after 360 days, after stopping ART.

The company is hoping to establish a path toward human trials with the FDA by the end of the year.

Go to slide 43 in the presentation:

http://www.enochianbio.com/wp-content/uploads/2021/09/HCW-Investor-Deck_09.13.2021pdf.pdf
« Last Edit: September 17, 2021, 09:53:53 pm by MitchMiller »

 


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