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Author Topic: Brec1 - recombinase with encouraging results  (Read 3415 times)

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Offline Jmarksto

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  • Posts: 667
Brec1 - recombinase with encouraging results
« on: February 24, 2016, 12:18:23 am »

This looks promising, perhaps more promising than Crisper-cas9....

www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.3467.html

Current combination antiretroviral therapies (cART) efficiently suppress HIV-1 reproduction in humans, but the virus persists as integrated proviral reservoirs in small numbers of cells. To generate an antiviral agent capable of eradicating the provirus from infected cells, we employed 145 cycles of substrate-linked directed evolution to evolve a recombinase (Brec1) that site-specifically recognizes a 34-bp sequence present in the long terminal repeats (LTRs) of the majority of the clinically relevant HIV-1 strains and subtypes. Brec1 efficiently, precisely and safely removes the integrated provirus from infected cells and is efficacious on clinical HIV-1 isolates in vitro and in vivo, including in mice humanized with patient-derived cells. Our data suggest that Brec1 has potential for clinical application as a curative HIV-1 therapy
« Last Edit: February 24, 2016, 12:21:26 am by Jmarksto »
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03/15/12 Negative
06/15/12 Positive
07/11/12 CD4 790          VL 4,000
08/06/12 CD4 816/38%   VL 49,300
08/20/12 Started Complera
11/06/12 CD4   819/41% VL 38
02/11/13 CD4   935/41% VL UD
06/06/13 CD4   816/41% VL UD
10/28/13 CD4 1131/45% VL 25
02/25/14 CD4   792/37% VL UD
07/09/14 CD4 1004/39% VL UD
11/03/14 CD4   711/34% VL UD
03/13/15 CD4   833/36% VL UD
04/??/15 Truvada & Tivicay
06/01/15 CD4 1100/50% VL UD
10/16/15 CD4   826/43% VL UD
??/??/2017 Descov & Tivicay
2017 VL UD, CD4 stable around 850
2018 VL UD, CD4 stable around 850

Offline Almost2late

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  • Posts: 1,447
Re: Brec1 - recombinase with encouraging results
« Reply #1 on: February 26, 2016, 09:35:47 pm »
This news has been spreading on the internet and I agree it holds lots of promise.. Will be crossing my fingers that this does what we hope.. I believe I read the researchers are out of Germany and you know what they say about German engineering  ;)
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Offline Matts

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  • Posts: 272
Re: Brec1 - recombinase with encouraging results
« Reply #2 on: February 27, 2016, 11:53:24 am »
If somebody should be interested- a bit more about the treatment and when it will be possibly available:

http://news.newsdirectory2.com/aids-hamburger-researchers-give-hope-to-hiv-cure/

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