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Recent Posts

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1
Here is an abstract BTW and ill fish out the full one later this week.

http://annals.org/aim/article-abstract/2707334/mechanisms-contribute-profound-reduction-hiv-1-reservoir-after-allogeneic-stem

Quote
Mechanisms That Contribute to a Profound Reduction of the HIV-1 Reservoir After Allogeneic Stem Cell Transplant

Abstract
Background:
The multifactorial mechanisms associated with radical reductions in HIV-1 reservoirs after allogeneic hematopoietic stem cell transplant (allo-HSCT), including a case of HIV cure, are not fully understood.

Objective:
To investigate the mechanism of HIV-1 eradication associated with allo-HSCT.

Design:
Nested case series within the IciStem observational cohort.

Setting:
Multicenter European study.

Participants:
6 HIV-infected, antiretroviral-treated participants who survived more than 2 years after allo-HSCT with CCR5 wild-type donor cells.

Measurements:
HIV DNA analysis, HIV RNA analysis, and quantitative viral outgrowth assay were performed in blood, and HIV DNA was also measured in lymph nodes, ilea, bone marrow, and cerebrospinal fluid. A humanized mouse model was used for in vivo detection of the replication-competent blood cell reservoir. HIV-specific antibodies were measured in plasma.

Results:
Analysis of the viral reservoir showed that 5 of 6 participants had full donor chimera in T cells within the first year after transplant, undetectable proviral HIV DNA in blood and tissue, and undetectable replication-competent virus (<0.006 infectious unit per million cells). The only participant with detectable virus received cord blood stem cells with an antithymocyte globulin–containing conditioning regimen, did not develop graft-versus-host disease, and had delayed complete standard chimerism in T cells (18 months) with mixed ultrasensitive chimera. Adoptive transfer of peripheral CD4+ T cells to immunosuppressed mice resulted in no viral rebound. HIV antibody levels decreased over time, with 1 case of seroreversion.

Limitation:
Few participants.

Conclusion:
Allo-HSCT resulted in a profound long-term reduction in the HIV reservoir. Such factors as stem cell source, conditioning, and a possible “graft-versus-HIV-reservoir” effect may have contributed. Understanding the mechanisms involved in HIV eradication after allo-HSCT can enable design of new curative strategies.

Primary Funding Source:
The Foundation for AIDS Research (amFAR).
2
Off Topic Forum / Re: One year positive.
« Last post by JimDublin on Today at 07:22:38 pm »
23 cool, Happy Birthday and, I hope you enjoyed chocolate cake despite the sugar diet.

Quote
I wish to everyone else sharing their bdays with me a happy bday.
Seriously its my Mothers Birthday today so you are in good company.   

Jim
3
Even the Berlin patient had a few negative Elisa results if i recall for a while, anyhow i suspect it will be more a possible functional cure one day for some, with longer treatment gaps if it works out, we will see how time goes on. In the meantime it will be interesting to see the published results from this latest phase.

Jim
4
Off Topic Forum / One year positive.
« Last post by fabio on Today at 06:40:42 pm »
Officially 23,I wish to everyone else sharing their bdays with me a happy bday.
I hope I get to post the same when I go 80. To 100 more years.
Thank you everyone...:)
5
I thought it was interesting that the one patient had no anti-bodies at all.  If he goes for several years without anti-bodies -- well, that would be something.  Sign me up! 

[I *did* try to sign up a few years ago for a Sangamo D32 trial.  They couldn't get enough HIV out of my blood to do a genotype and I was DQ'd]
6
Well time will tell with this one, we all recall the kids who were "cured" but when testing a few years later it was back. Long term remission perhaps

Quote
The patients are keeping up their antiretroviral treatment,


Currently the Berlin patient has a functional cure but even than he still has HIV in some tissues just not replicating or its in a dormet state in laymens terms.

Always something to learn though

Jim
7
This is a stem-cell Delta-32 experiment (aka Tim Brown).  Here's the juicy part (I always take my juice with a grain of salt!)

Scientists from the Institute for AIDS Research IrsiCaixa in Barcelona and the Gregorio Maranon Hospital in Madrid have managed to remove the virus from the blood and tissues of six patients using the treatment.

But the research, published on Monday in the Journal of Internal Medicine, said one patient now has no antibodies fighting the infection, suggesting it has been completely eliminated.

Here's the article -- it's short:

http://www.theolivepress.es/spain-news/2018/10/16/spanish-doctors-eliminate-hiv-from-patient-in-stem-cell-transplant-trial/

8
Thanks, JimSublin!  I appreciate it! 
9
Quote
- If my injured finger was inserted deep enough into his rectum, couldn’t that expose the burn (it looked pretty gnarly) to potentially tainted rectal secretions?  That is still not a threat? 

My backside is not tainted ...  ::) Anyhow moving on, Asked and answered already. Finger deep or to your elbow to be blunt about it no difference, no risk

Quote
- As regards my infidelity, I have do not plan on having intercourse with my spouse until I take a test at eight weeks.  Just to ensure she is safe.  She doesn’t know about this encounter, but I can’t put her at risk. 

Asked and answered already.

If you have unprotected intercourse with your wife you are accepting a HIV risk to you!

Ill close with the encounter with the guy was no real world risk, just a lot of guilt perhaps but no amount of guilt creates a HIV risk.  The only risk you had was from your wife and if you ever have a real world exposure test at 6 weeks and 13 weeks post exposure for a conclusive result "Again" this encounter with the guy was not an exposure, move on with your life.

Jim

10
Thanks tons, Ray.


No Problem !

I think you will find this area very affordable, in all aspects, including housing, apt. rents, dining etc

Under Ryan white dental services. I believe you are only entitled to one cleaning per year, and a thorough, exam. You can pay for additional cleanings out of pocket. I had a lower partial made, which was completely covered, at a cost of about 1,200.00 dollars. All depends on what you qualify for.

1,000.00 to 1,200.00/ month,... should get you a VERY nice apt here in this area. You should be able to find rental units on-line for the Clearwater, Dunedin, and Palm Harbor area.

As far as gyms in the area, there are plenty, no shortage.


Take care----Ray
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