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Author Topic: How Does HIV Overcome Numerous Obstacles to Infect the Body?  (Read 2031 times)

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How Does HIV Overcome Numerous Obstacles to Infect the Body?
« on: January 21, 2017, 12:04:55 pm »
The strains of HIV that succeed in establishing an infection through sexual transmission have various properties that facilitate their evasion of the body’s numerous lines of defense against such an invasion.

HIV must first infect a target cell at the initial site of infection, such as the rectum or vagina. Next, the virus needs to travel through the mucus membranes of the genital track and then the tightly packed epithelial cells, which form a barrier against the invasion of pathogens. Then, HIV needs to evade the initial immune response: type-1 interferons, specifically interferon-alpha2 and interferon-beta.

Considering all these obstacles, the per-act chance of transmitting HIV when someone living with the virus has a detectable viral load and ejaculates into the rectum or vagina of an HIV-negative partner is still quite small.

Read more:
https://www.poz.com/article/hiv-overcome-numerous-obstacles-infect-body
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