Welcome, Guest. Please login or register.
April 23, 2024, 05:32:35 pm

Login with username, password and session length


Members
  • Total Members: 37649
  • Latest: MSB92
Stats
  • Total Posts: 773274
  • Total Topics: 66346
  • Online Today: 417
  • Online Ever: 5484
  • (June 18, 2021, 11:15:29 pm)
Users Online
Users: 3
Guests: 354
Total: 357

Welcome


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Do I Have HIV?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Low level VL linked to defective copies released from viral reservoir  (Read 3895 times)

0 Members and 1 Guest are viewing this topic.

Offline Jim Allen

  • Administrator
  • Member
  • Posts: 22,383
  • Threads: @jim16309
    • Social Media: Threads
A small study confirms previous conclusions & studies that blips can be defective HIV copies from viral reservoirs.

Article from I-base: https://i-base.info/htb/44755
Low level viral load on effective ART is linked to clonal expansion of reservoir: not affected by modifying ART

In Short:

Quote
Researchers investigating new and persistently detectable viral load in four people with a previous history of suppressive ART report that this is caused by clonal expansion of reservoir cells. All cases included people having excellent adherence and no evidence of drug resistance.

The four participants (P14) had been living with HIV for more than 15 years (range 15 to 32 years) and had been undetectable on long-term ART from 7 to 27 years, with good CD4 counts. Treatment changes, including intensification had not been successful.

P1 had persistently detectable viremia for more than four years, with a median plasma viral load of 80 copies/mL (range 37 to 156).

P2 had intermittent periods of detectable viremia for more than ten years, with a median of 75 copies/mL (range <20 to 300).

P3 had persistently detectable viremia for over four years, with a median of 123 copies/mL (range 26 to 857).

P4 was the most extreme example, with a median viral load of 2979 copies/mL (range 1145 to 5138) for almost two years.




HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

My Instagram
Threads

Offline leatherman

  • Global Moderator
  • Member
  • Posts: 8,623
  • Google and HIV meds are Your Friends
Re: Low level VL linked to defective copies released from viral reservoir
« Reply #1 on: August 15, 2023, 12:23:51 pm »
P2 had intermittent periods of detectable viremia for more than ten years, with a median of 75 copies/mL (range <20 to 300).
P2 could almost be me. Although I was P1 for my first 5 years with a much larger VL

intermittent periods of detectable viremia for more than 12 years, with a median of approx 175 copies/mL (range <20 to 7800)

That wouldn't count the blip 5 years later of 59k.

Two years afterwards, I changed regimens to Precobix/Tivicay (no resistance issues to anything prior, just an updated regimen) and haven't blipped in 11yrs.
leatherman (aka Michael)

We were standing all alone
You were leaning in to speak to me
Acting like a mover shaker
Dancing to Madonna then you kissed me
And I think about it all the time
- Darren Hayes, "Chained to You"

 


Terms of Membership for these forums
 

© 2024 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.