Meds, Mind, Body & Benefits > Research News & Studies

Lenacapavir capsid inhibitor (GS-6207) - CAPELLA trial

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Da2020:
Hopefully, it gets approved soon and I am eager to switch to  twice a year injections opposed to daily pills. :)

Jim Allen:

--- Quote from: Da2020 on May 22, 2022, 04:38:15 pm ---Hopefully, it gets approved soon and I am eager to switch to  twice a year injections opposed to daily pills. :)

--- End quote ---

From what I read and the results, Initial approve and that's a "if" that happens I think will be in combination of daily oral drugs for viral suppression.

If it was just 6 monthly injection and done, then I would also be interested as well but we're not there yet

Loa111:

--- Quote from: Jim Allen on May 22, 2022, 05:00:54 pm ---From what I read and the results, Initial approve and that's a "if" that happens I think will be in combination of daily oral drugs for viral suppression.


--- End quote ---

So if with the 6 month injection and if daily oral drugs are still required anyway, is the benefit that one is taking less drugs on a daily basis?

Jim Allen:
Well... The way I look at it is if it works then it's a first and, should there be any additional 6 monthly treatments in the future then prehaps a combination of those could truly provide an alternative to daily pills.

The current benefits that CAPELLA trial phase 3 is looking into is suppressing the VL in those with HIV that has become multidrug-resistant. These injections and an optimized daily meds will hopefully suppress the virus and the results so far are promising.

The Phase II CALIBRATE trial, is looking into 6 monthly injections with the daily combinations for those without resistance.

lenacapavir +  daily alafenamide/emtricitabine
Or;
lenacapavir +  daily bictegravir
Or;
lenacapavir +  daily bictegravir/TAF/emtricitabine
Or;
lenacapavir +  daily TAF

I would be more interested if it was in combination with DTG or 3TC but even then it's not for me, However, hopefully it will provide other people with more treatment options to choose from.

(Sorry for any spelling issues, walking around Kilkenny today and only have this tiny phone with me)

Loa111:
Interesting...I'm on a 2 pill combo, so I would be open to the idea if this worked, of just taking of one my daily pills if the 6 monthly injection took care of the rest.

Thanks for the insight Jim & enjoy your walk around Kilkenny.

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