Jim Allen:
What daily pills + twice yearly injections to somewhat suppress the viral load? No thanks.
I get what you mean, though. However a long road to go before there is any drug combination, if it ever happens, that can, without daily meds, provide viral suppression purely from a once-per-six monthly injection.
Da2020:
I meant as a stand alone treatment without the daily pills. I know they were working on it with Merck and mercks drug had issues with reduction in CD4 counts. I don’t want a pill plus the twice a year injection either :)
Jim Allen:
--- Quote from: Da2020 on December 23, 2022, 12:29:50 pm ---I meant as a stand alone treatment without the daily pills. I know they were working on it with Merck and mercks drug had issues with reduction in CD4 counts. I don’t want a pill plus the twice a year injection either :)
--- End quote ---
That reminded me to update that thread, thanks. https://forums.poz.com/index.php?topic=75770 It was on hold, now continuing at a lower dose, and they dropped the idea of using it for PrEP. However, even if it works, its nowhere near 6 monthly injections.
Jim Allen:
https://www.poz.com/article/twiceyearly-sunlenca-works-initial-hiv-treatment
--- Quote ---
The new injectable antiretroviral keeps HIV under control, but it still needs an equally long-acting partner.
Sunlenca (lenacapavir), a long-acting injectable medication recently approved for treatment-experienced people with multidrug-resistant HIV, also works well for people starting antiretroviral therapy for the first time, according to a recent report in The Lancet HIV.
Results from the CALIBRATE trial showed that around 90% of study participants who used Sunlenca—either as daily pills or injections every six months—in combination with other antiretrovirals achieved an undetectable viral load. --- End quote ---