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Author Topic: Spain: circulating HIV-1 strains might have gained virulence  (Read 2814 times)

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Offline elf

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Spain: circulating HIV-1 strains might have gained virulence
« on: April 07, 2014, 12:29:15 pm »
Quote
AIDS. 2014 Mar 14. [Epub ahead of print]
X4 tropic viruses are on the rise in recent HIV-1 seroconverters in Spain.
Sierra-Enguita R1, Rodriguez C, Aguilera A, Gutierrez F, Eiros JM, Caballero E, Lapaz M, Soriano V, Del Romero J, de Mendoza C.
Author information
Abstract
BACKGROUND::

Transmission of HIV-1 with drug resistance mutations (DRMs) in Spain remains stable around 13%. However, the profile of recent HIV-1 seroconverters has experienced significant changes.
METHODS::

Retrospective analyses of all individuals with HIV-1 infection acquired within the past 12 months recruited at a national registry since year 1997.
RESULTS::

A total of 1032 recent HIV-1 seroconverters were examined (92.2% men; median age 31 years; 84% homosexual men). At the moment of diagnosis, median plasma HIV-RNA and CD4 cell counts were 4.5 log copies/ml and 558 cells/μl, respectively. A total of 136 individuals (13.8%) carried non-B subtypes. Major primary DRMs were found in 13.4%, being 7.7% for nucleoside reverse transcriptase inhibitor (NRTI), 5.8% for nonnucleoside reverse transcriptase inhibitor (NNRTI) and 2.9% for protease inhibitor. NRTI DRM significantly declined from 23.7% in 1997-2000 to 5.7% in 2010-2012 (P < 0.01). Overall, X4 viruses were found in 19.7% of HIV-1 seroconverters, increasing from 11.5% before 2001 to 23.3% since year 2010 (P = 0.04). Interestingly, median CD4 cell counts were significantly lower in seroconverters diagnosed during the last period after adjusting for potential confounders. In multivariate analyses, X4 tropism, high HIV-RNA, foreigners and non-B subtypes were independent predictors of lower CD4 cell counts.

CONCLUSION::

Transmission of NRTI DRM has declined significantly in recent HIV-1 seroconverters in Spain. Conversely, X4 tropic viruses are on the rise and currently account for 23.3% of new HIV-1 infections. These individuals present with lower CD4 cell counts suggesting that circulating HIV-1 strains might have gained virulence.

http://www.ncbi.nlm.nih.gov/pubmed/24637545
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