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Author Topic: Combination nanotherapy drastically reduces the amount of HIV produced by cells  (Read 1886 times)

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Offline GoForIt

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A combination of fine-particle formulations of the drugs atazanavir and ritonavir, plus an immune-dampener drug designed to induce cells to keep hold of the drugs for longer, has produced a 100-fold decline in the number of CD4 cells in the lymph nodes of mice infected with HIV and an even greater reduction in the amount of new virus produced by the cells. Pre-treatment with the drug also produced infections with considerably lower viral loads, suggesting this concept might be used in PrEP as well as treatment. The combination of drugs prevented, to a large extent, the uptake of HIV into T-lymphocyte cells and thus has considerable potential to either prevent or suppress long-term infection.


Read the entire article here:

http://www.aidsmap.com/Combination-nanotherapy-drastically-reduces-the-amount-of-HIV-inside-cells-in-mice/page/3033724/
08/09/2013  Diagnosed WB positive
08/20/2013  CD4-506(28%)  VL-10,800
09/12/2013  CD4-391(28%)  VL-14,900
09/17/2013  Start ART (Truvada + Tivicay)
10/11/2013  CD4-377(26%)  VL-UD
12/20/2013  CD4-590(??%)  VL-UD
03/18/2014  CD4-660(29%)  VL-UD
07/22/2014  CD4-613(29%)  VL-UD
08/01/2014   Start Phase 3 TAF (Truvada 2.0) Clinical Trial (TAF + Tivicay)
10/09/2014  CD4-498(29.5%) VL-UD
11/06/2014  CD4-600(30.2%) VL-UD
01/30/2015  CD4-529(31.3%) VL-UD
07/25/2015  CD4-742(36.5%) VL-UD
10/06/2015  CD4-765(28.9%) VL-UD
01/05/2016  CD4-907(33.1%) VL-UD
03/24/2016  CD4-770(33.5%) VL-UD
06/20/2016  CD4-850(35.4%) VL-UD

Dr. Mark Wainberg on Dolutegravir:
Video 1: https://youtu.be/wCXOgLJqJAY
Video 2: https://youtu.be/DKiaD7fHO-s

 


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