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Author Topic: TAF Versus TDF: What’s the Difference?  (Read 2818 times)

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Offline Jim Allen

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TAF Versus TDF: What’s the Difference?
« on: December 16, 2019, 01:50:15 pm »
The question TAF Versus TDF comes up often enough so posting this publication here. It's a long article so ill just quote the bottom line from the end and highlight the topics covered.

https://www.poz.com/basics/hiv-basics/taf-versus-tdf-difference

Treatment Effectiveness
Kidney Problems
Bone Loss
Blood Fats and Weight Gain
TDF and TAF for PrEP

The Bottom Line

TDF and TAF are both very effective for HIV and hepatitis B treatment as well as for PrEP. TAF and its coformulations are less likely to cause unfavorable changes in kidney and bone biomarkers, but serious kidney problems and bone loss are uncommon with either drug. TDF has the edge over TAF when it comes to blood fat levels and weight gain. TAF may be a better option for those at risk for kidney or bone problems, but both are safe options for most people.
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