KP1461

[mark86]

This looked so promising at one point then died a death very quickly. Its a been a while now, anyone know how if there has been an investigation into how it got so far before being discovered to have no effect what so ever?

Thanks,
Mark86

[Inchlingblue]

The study was stopped due to "stunning setbacks,"

http://www.projectinform.org/news/2008/061208.shtml

[georgep77]

KP1461 was a joke 

[veritas]

georgep77,

I agree with you.  From day one I did not trust this drug. No one answered the question that if it didn't work. what regimen could you put together after having all those mutations.

Some researches have no morals !!

veritas

[tash08]

KP-1461 looks like both thymine and cytosine, and will occasionally replace one of the normal bases in DNA, causing more errors.

"It really mucks up the genetic information inside the viral DNA," said Reno.
Disrupting HIV's replication doesn't directly destroy the virus, however, at least not immediately. It's the build-up of genetic mistakes that finally destroys it.

That build-up can take time, and could vary depending on the patient and the strain of HIV. The results of the latest Phase Two clinical trial, completed last year with 13 patients, were mixed; some patients saw no drop in their viral load, while others saw a dramatic drop. The scientists are currently working to publish the study results.

What's clear is that KP-1461 does eventually destroy HIV in some patients, unlike the current batch of antiretroviral drugs, which limit the reproduction of the virus but fail to destroy it.

KP-1461 doesn't have any known side effects, but the worry from the Food and Drug Administration is that a drug that induces mutation in a virus could also cause dangerous mutations in the patient's own DNA.

So far it doesn't appear to cause short-term mutations in animal models, but longer-term studies are necessary to eliminate the possibility, said Robert Smith, a professor at the University of Washington who studies other lethal mutagenic drugs.

Mutagenic drugs could be used to fight other diseases as well, such as polio, hepatitis C and influenza. KP-1461 is at the forefront of this new avenue of research.

"Intellectually this is exciting; it's a very creative approach," said Smith. "From a practical perspective, there are still a lot of questions."

http://dsc.discovery.com/news/2009/02/09/hiv-mutation.html

[veritas]

tash08,

That article gives me additional reasons for not taking KP1461 !

veritas

[mark86]

It sounds like we are saying that KP-1461 is very much alive and undergoing testing right now. Have i read it right

[sensual1973]

two articles above and both contradict eachother !!!

[MitchMiller]

The Koronis web site just says they're still looking into the results, but provide no details. 

I'm guessing it's dead.  They originally said two months to analyze everything and it's been much longer.  I'm wondering if maybe they're just getting desperate for funding and have decided to give KP1461 another go-round in the press.

I thought I had read that a Chinese company was also working on a similar line of research, but I can't seem to find any more info on it.  Perhaps it also bit the dust.

[georgep77]

KP1461 was a joke 

I agreed with you georgep77 

[John2038]

I thought I had read that a Chinese company was also working on a similar line of research, but I can't seem to find any more info on it.  Perhaps it also bit the dust.

I would be interested to get the link 

So far, the only recent publication I have find in a chinese website and about this "drug" is on this website:
http://www.popscichina.com/html/zazhizhuanqu/xin/2009/0224/453.html

What is said there is old stuff, despite the fact that the article itself is recent.
It's content is a translation of the article published on discovery.

It is indeed surprising that some are still talking about this past drug.

Now, if I could give a personal opinion on this drug, I won't say it's bullshit:

The concept is great, and there are no reasons (nor evidences) that a "super mutation" won't mutate itself again.
I can personally imagine that the mutations will continue until the virus die, unable to replicate again.

INMHO either this research haven't been push enough far (could it be by changing the drug composition), or there is something that we are hidding to us:  the way this research have ended is more than suspect.

EDIT: My crap English, as usual..

[sensual1973]

if this drug that was mentioned years back vanish -which was a clear messae that their technique was not sufficient enough to come up with stong conclusion or positive remarks,then why is it resurfacing again with ambigoius and vague resutls.is this just playing with our feeling,us who had many disappoionting studys failing in the past?

i just dont get it ?!!!

peace