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Author Topic: neuropathy and B6  (Read 2373 times)

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Offline harleymc

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neuropathy and B6
« on: January 06, 2025, 05:47:34 pm »
There are quite a few of us with neuropathy, supplements containing B6 can cause this.

https://www.tga.gov.au/news/safety-alerts/health-supplements-containing-vitamin-b6-can-cause-peripheral-neuropathy

Offline leatherman

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Re: neuropathy and B6
« Reply #1 on: January 06, 2025, 06:46:40 pm »
definitely something to keep an eye on!

https://pmc.ncbi.nlm.nih.gov/articles/PMC10343656/
The Role of Vitamin B6 in Peripheral Neuropathy: A Systematic Review

Quote
Both vitamin B6 deficiency and high B6 intake have been described as risk factors for developing peripheral neuropathy (PN)
ouch! too much or too low b6 can be a problem.

Conclusion:
Quote
In summary, the present study draws the following conclusions regarding B6 and PN.

Low vitamin B6 levels can be seen in patients suffering from peripheral neuropathy of various etiologies. However, this finding is due either to overall poor nutritional status (which means low levels of other vitamins, deficiencies in which can cause PN, such as B12) or to an adverse effect of treatments that these patients received for conditions that can lead to neuropathy, such as diabetes or chronic renal failure. Therefore, to date, there is no firm evidence that low B6 levels have a direct causal relationship with PN. Measuring levels of B6 in patients with CIAP who receive no nutritional supplements could shed light on this association and should be undertaken as a research project in the future.

Higher vitamin B6 levels, which usually occur following the taking of nutritional supplements, may lead to the development of a predominantly, if not exclusively, sensory neuropathy of the axonal type. After pyridoxine discontinuation, such patients do subjectively report improved symptoms. However, the studies available to date have had small sample sizes, and the evaluation of patients has mainly included the presence of symptoms and not detailed clinical or electrophysiological evaluations.

Many studies have suggested a subjective improvement of neuropathy symptoms in patients suffering from PN of various etiologies after receiving B6 supplementation. In none of those studies, however, has B6 been administered as a monotherapy but as part of a combination treatment, usually with other vitamins. Therefore, the potential therapeutic role of B6 cannot be confirmed to date.

In contrast, supplementation of B6 vitamins, even as part of a nutritional multivitamin supplement, has not proven to be harmful at permitted daily doses in patients who already suffer from PN.

I've had recurring low b6 through the years and have had to have injections several times. The cause in my case is still undetermined. I take a 100mg dose every three days....which reminds me that I've been out for a month and need to get some more before I start having issues.
leatherman (aka Michael)

We were standing all alone
You were leaning in to speak to me
Acting like a mover shaker
Dancing to Madonna then you kissed me
And I think about it all the time
- Darren Hayes, "Chained to You"

 


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