Welcome, Guest. Please login or register.
June 15, 2024, 01:32:13 am

Login with username, password and session length


Members
Stats
  • Total Posts: 773726
  • Total Topics: 66405
  • Online Today: 291
  • Online Ever: 5484
  • (June 18, 2021, 11:15:29 pm)
Users Online
Users: 0
Guests: 276
Total: 276

Welcome


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Do I Have HIV?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: "Researchers identify a new HIV reservoir"  (Read 5376 times)

0 Members and 1 Guest are viewing this topic.

Offline tryingtostay

  • Member
  • Posts: 591
"Researchers identify a new HIV reservoir"
« on: April 17, 2017, 11:33:30 pm »
"The fact that HIV-infected macrophages can persist means that any possible therapeutic intervention to eradicate HIV might have to target two very different types of cells."


Link:

https://medicalxpress.com/news/2017-04-hiv-reservoir.html


Article:

HIV cure research to date has focused on clearing the virus from T cells, a type of white blood cell that is an essential part of the immune system. Yet investigators in the Division of Infectious Diseases at the University of North Carolina School of Medicine have found the virus persists in HIV-infected macrophages. Macrophages are large white blood cells found in tissues throughout the body including the liver, lung, bone marrow and brain. The discovery of this additional viral reservoir has significant implications for HIV cure research. These findings were published in Nature Medicine on Monday, April 17.

"These results are paradigm changing because they demonstrate that cells other than T cells can serve as a reservoir for HIV," said Jenna Honeycutt, Ph.D., lead-author and postdoctoral research associate in the UNC Division of Infectious Diseases. "The fact that HIV-infected macrophages can persist means that any possible therapeutic intervention to eradicate HIV might have to target two very different types of cells."

Last spring, this laboratory lead by J. Victor Garcia, Ph. D., professor of medicine, microbiology and immunology at UNC School of Medicine, demonstrated the ability of tissue macrophages to support HIV replication in vivo in the total absence of human T cells. But how macrophages would respond to antiretroviral therapy (ART) and whether macrophages represented a reservoir for HIV after treatment were unknown.

Macrophages are myeloid lineage cells that have been implicated in HIV pathogenesis and in the trafficking of virus into the brain. Using a humanized myeloid-only mouse (MoM) model devoid of T cells, Garcia and his team showed that ART strongly suppresses HIV replication in tissue macrophages. Yet when HIV treatment was interrupted, viral rebound was observed in one third of the animals. This is consistent with the establishment of persistent infection in tissue macrophages.

"This is the first report demonstrating that tissue macrophages can be infected and that they respond to antiretroviral therapy," Honeycutt said. "In addition, we show that productively infected macrophages can persist despite ART; and most importantly, that they can reinitiate and sustain infection upon therapy interruption even in the absence of T cells—the major target of HIV infection."

Now that Garcia and his team know HIV persists in macrophages, the next step will be to determine what regulates HIV persistence in tissue macrophages, where in the body persistently infected macrophages reside during HIV treatment and how macrophages respond to possible therapeutic interventions aimed at eradicating HIV from the body.


Offline Jim Allen

  • Administrator
  • Member
  • Posts: 22,545
  • Threads: @jim16309
    • Social Media: Threads
Re: "Researchers identify a new HIV reservoir"
« Reply #1 on: April 18, 2017, 06:09:56 am »
Yeah, so I think HIV infecting macrophages was also already well known, as studies looked into HIv infected macrophage in macrophage rich tissues before.

I don't believe we will have a cure and tend to see the cure word just as something  used to sell newspapers and as a pitch tool for funding and not as a real goal, so for that reason I also don't see HIV infected tissue as a barrier when i think of research.

I tend to see HIV research as just finding out more and from that perhaps having more effective treatments and prevention tools.

Jim

http://jvi.asm.org/content/90/20/8968
https://retrovirology.biomedcentral.com/articles/10.1186/1742-4690-9-82
HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

My Instagram
Threads

Offline tryingtostay

  • Member
  • Posts: 591
Re: "Researchers identify a new HIV reservoir"
« Reply #2 on: April 18, 2017, 07:57:41 am »
Yeah, I was kinda wondering about the topic written.  Was like, wow wtf, they just now find this out?  I think this is a part of the HIV research field that doesn't have as much research attention as finding a way to rid the T cells of HIV.  I thought I read one article a while back about a research team working on Macrophage HIV infection.  My overall impression of the article put a damper on my hopes, yet this could be the one-two punch needed to knock out this virus. 

Offline CaveyUK

  • Global Moderator
  • Member
  • Posts: 1,642
Re: "Researchers identify a new HIV reservoir"
« Reply #3 on: April 19, 2017, 05:43:19 pm »
I too read this and thought 'Maybe they should have looked at some of the existing research about this'....

HIV - Basics
HIV 101
You can read more about Transmission and Risks here:
HIV Transmission and Risks
You can read more about Testing here:
HIV Testing
You can read more about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read more about HIV prevention here:
HIV prevention
You can read more about PEP and PrEP here:
PEP and PrEP

Offline Almost2late

  • Member
  • Posts: 1,447
Re: "Researchers identify a new HIV reservoir"
« Reply #4 on: April 22, 2017, 06:54:46 pm »
I thought I read one article a while back about a research team working on Macrophage HIV infection.

Yep.. this one was from over a year ago  :-\
https://www.sciencedaily.com/releases/2016/03/160308134758.htm

Offline Almost2late

  • Member
  • Posts: 1,447
Re: "Researchers identify a new HIV reservoir"
« Reply #5 on: April 25, 2017, 10:45:53 am »
Macrophages I'm learning are quite amazing, according to this article they not only help the immune system fight bad guys but they also help your 💓 beat..

https://www.sciencedaily.com/releases/2017/04/170420141857.htm

Sure would like to see more research to clear them of hiv.

Offline leatherman

  • Global Moderator
  • Member
  • Posts: 8,661
  • Google and HIV meds are Your Friends
Re: "Researchers identify a new HIV reservoir"
« Reply #6 on: April 25, 2017, 01:04:32 pm »
Sure would like to see more research to clear them of hiv.
yea! more pills to take :P ::)

  ;D don't get me wrong. I used to take 32 pills a day and I'm down to 5 now. I wouldn't mind throwing in a couple more if they'd squeeze a bit more HIV outta me.  ;)
leatherman (aka Michael)

We were standing all alone
You were leaning in to speak to me
Acting like a mover shaker
Dancing to Madonna then you kissed me
And I think about it all the time
- Darren Hayes, "Chained to You"

Offline Almost2late

  • Member
  • Posts: 1,447
Re: "Researchers identify a new HIV reservoir"
« Reply #7 on: April 26, 2017, 08:05:43 am »
yea! more pills to take :P ::)

Or a bigger one ???

 


Terms of Membership for these forums
 

© 2024 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.