Author Topic: Bictegravir (GS-9883) Phase 1/2 suppressed HIV as well as Tivicay (dolutegravir) (Read 7764 times)

Matts · « **on:** June 21, 2016, 06:42:37 pm »

http://www.gilead.com/news/press-releases/2016/6/gilead-presents-preliminary-data-on-bictegravir-an-investigational-integrase-strand-transfer-inhibitor-for-the-treatment-of-hiv

I think that Bictegravor of Gilead could become a new Blockbuster. I dont find all the links of the studies, but it works better than Tivicay against resistances. It is quite impressive. The new STR of Bictegravir+TAF+Emtricitabine will work for everyone, even with heavy resistance issues. Let's see

gorka · « **Reply #1 on:** June 21, 2016, 06:58:53 pm »

I am supposed to get my pills for study tomorrow. That said I dont know which one I will be taking either this or Triumeq

gorka · « **Reply #2 on:** June 22, 2016, 09:15:38 pm »

Took my first ever ART pills today. Dont know which one I am actually taking either Bictegravor/TFA/TFC (the pill is HUGE) or Triumeq but they give u both and one is placebo. Did not have any side effects so far that I could tell knock on wood. Hope it continues this way.

gorka · « **Reply #3 on:** June 23, 2016, 09:34:24 am »

I take that back. Triumeq pill is huge the new drug that includes Bictegravir is tiny (easily 3 times smaller)

gorka · « **Reply #4 on:** June 26, 2016, 11:05:02 am »

Been taking meds for a week now. Absolutely no side effects that I can notice other than some anxiety but that could be from anything. So I guess I am tolerating either new drug or Triumeq pretty well. My initial viral load was 300 copies/ml and test before starting medication was 800 copies/ml. I tested negative in Dec 2015. Am I considered viremic controller or you need to be wo meds for longer to determine that?

Matts · « **Reply #5 on:** June 26, 2016, 03:00:05 pm »

I wish You the best for Your trial. I am surprised that they have choosen You with 800 copies.

But anyway, it is a new drug and nobody knows the side effects yet. BIC is similar to Dolutegravir. DTG can cause insomnia, anxiety, psychosis. Maybe the some for BIC.
But as it looks, it can still work as once-daily even for patients resistant to Elvitegravir, Raltegravír or Dolutegravir.

Please keep us reporting.

gorka · « **Reply #6 on:** June 26, 2016, 03:28:11 pm »

Thanks Matts. Yeah I was surprised also. Dr said I should do really well on either drug. I wish I didnt have to take placebo for so long though (96 weeks)

gorka · « **Reply #7 on:** July 05, 2016, 12:54:21 pm »

I have been now on meds for about 10 days. I started experiencing some side effects. The best way I can describe it is I seem to get tingling in my face and I also get the feeling as if I am getting a cold or getting over it about 20 minutes after taking meds. it lasts for a few hours after taking the meds but it goes away as the day goes by so by evening I dont have the same sensation. Again I dont know what I am taking either new drug or Triumeq. Anyone on Triumeq experience anything similar?

CaveyUK · « **Reply #8 on:** July 06, 2016, 02:10:43 pm »

Quote from: gorka on July 05, 2016, 12:54:21 pm

I have been now on meds for about 10 days. I started experiencing some side effects. The best way I can describe it is I seem to get tingling in my face and I also get the feeling as if I am getting a cold or getting over it about 20 minutes after taking meds. it lasts for a few hours after taking the meds but it goes away as the day goes by so by evening I dont have the same sensation. Again I dont know what I am taking either new drug or Triumeq. Anyone on Triumeq experience anything similar?

Gorka. Low level side effects, if caused by HIV meds should calm down over time. Obviously, can't speak for the new drug but this is a general pattern.

If it becomes a concern feed it back to your doctor.

If you have a specific question about Triumeq, it's best to post a new thread in the 'Treatment & Side Effects' forum as many won't venture into the research forum.

gorka · « **Reply #9 on:** July 09, 2016, 07:08:14 pm »

wanted to update this thread as well that switching to evening seems to resolve issues I was having in case anyone else in the study experiences similar problems.

gorka · « **Reply #10 on:** August 03, 2016, 03:11:38 pm »

I have been taking drugs for over a month now and just got a note that my VL is undetectable. So either Triumeq or Bactigravir is working great. Some goodn ews out of all this. Yaaay.

CaveyUK · « **Reply #11 on:** August 04, 2016, 03:19:39 pm »

great news gorka.

The Integrase class of drugs are phenomenal at viral suppression.

gorka · « **Reply #12 on:** October 03, 2016, 12:58:47 am »

been on the meds for 3 months now and switched back to taking them in the morning along with my blood pressure meds. it seems the side effects I was experiencing in the beginning have disappeared. still doing great VL undetectable and high CD count although I have to say I do feel depressed and not motivated at times

Mightysure · « **Reply #13 on:** January 11, 2017, 06:34:48 pm »

Hey,
How's the study going? Is this a study comparing Triumeq to the BIC combo? That's so cool bc you're getting your meds for free without t hassle of insurance and specialty pharmacies. And you're contributing to HIV-1 knowledge.

How much longer do you have?

gorka · « **Reply #14 on:** January 11, 2017, 08:10:55 pm »

The study I am in compares Triumeq to Bactegravir combo. I am not sure what I am taking though. I will know at week 96. Taking 2 pills one placebo and one for the drug. So far so good. Been undetectable after 4 weeks and stayed that way. The only bad part I gained weight and my cholesterol went up.

awakening · « **Reply #15 on:** February 14, 2017, 09:16:45 pm »

Quote

– Bictegravir in Combination with FTC/TAF Showed 97 Percent Rates of Virologic Suppression in Phase 2 Study –

http://www.gilead.com/news/press-releases/2017/2/gilead-presents-new-phase-2-data-on-bictegravir-an-investigational-integrase-strand-transfer-inhibitor-for-the-treatment-of-hiv

Jim Allen · « **Reply #16 on:** February 15, 2017, 11:22:14 am »

Well I think its impressive results despite the small trial size and looking forward to seeing the larger phase 3 study results on this one if they go ahead.

https://www.poz.com/article/gileads-investigational-bictegravir-treats-hiv-tivicay-dolutegravir

Gilead’s Investigational Bictegravir Treats HIV as Well as Tivicay (Dolutegravir)
Each integrase inhibitor was paired with Descovy (emtricitabine/tenofovir alafenamide) in a recent small trial.

Gilead Sciences’ investigational integrase inhibitor bictegravir (GS-9883) suppressed HIV as well as Tivicay (dolutegravir) when paired with Descovy (emtricitabine/tenofovir alafenamide) in a recent Phase II trial. Considering these results, along with previous promising Phase I trial findings, researchers concluded that bictegravir merits further study.

Investigators enrolled 98 people living with HIV who had not taken antiretrovirals before and randomized them to receive, along with Descovy, bictegravir (65 participants) or Tivicay 33 participants) on a blinded basis. Findings were presented at the 2017 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle.

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Author Topic: Bictegravir (GS-9883) Phase 1/2 suppressed HIV as well as Tivicay (dolutegravir) (Read 7764 times)