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Author Topic: Islatravir Plus Pifeltro Shows Promise as 2-Drug HIV Regimen  (Read 1125 times)

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Offline Jim Allen

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Interesting update, we have to see how stage 3 turns out of course.

Poz.com write-up in full: https://www.poz.com/article/islatravir-plus-pifeltro-shows-promise-2drug-hiv-regimen

In short:


Islatravir Plus Pifeltro Shows Promise as 2-Drug HIV Regimen
A mid-stage trial showed the combo suppressed HIV, was well tolerated and resulted in a low rate of virologic failure.

The randomized, double-blind trial enrolled 121 people with HIV who had not previously taken treatment for the virus and had no known resistance to ARVs.

The study had two parts. In part one, the participants were randomized to receive islatravir at either 0.25 milligrams, 0.75 mg or 2.25 mg plus 100 mg of Pifeltro and 300 mg of lamivudine or to receive Delstrigo. Twenty-four weeks later, in part two, those who received islatravir and who had an undetectable viral load (below 50) stopped taking lamivudine and kept taking the remaining two-drug regimen of islatravir plus Pifeltro for another 24 weeks.

Findings presented at the 2019 International AIDS Society Conference on HIV Science in Mexico City indicated that 90% of those who took 0.75 mg of islatravir—the dose that will continue on to Phase III trials—had a fully suppressed viral load at the trial’s 48-week mark, compared with 84% of those on the three-drug regimen. These rates were considered comparable.
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