Welcome, Guest. Please login or register.
June 24, 2022, 06:51:47 pm

Login with username, password and session length


Members
  • Total Members: 36518
  • Latest: joeyy
Stats
  • Total Posts: 764915
  • Total Topics: 65152
  • Online Today: 125
  • Online Ever: 5484
  • (June 18, 2021, 11:15:29 pm)
Users Online
Users: 1
Guests: 73
Total: 74

Welcome


Welcome to the POZ Community Forums, a round-the-clock discussion area for people with HIV/AIDS, their friends/family/caregivers, and others concerned about HIV/AIDS.  Click on the links below to browse our various forums; scroll down for a glance at the most recent posts; or join in the conversation yourself by registering on the left side of this page.

Privacy Warning:  Please realize that these forums are open to all, and are fully searchable via Google and other search engines. If you are HIV positive and disclose this in our forums, then it is almost the same thing as telling the whole world (or at least the World Wide Web). If this concerns you, then do not use a username or avatar that are self-identifying in any way. We do not allow the deletion of anything you post in these forums, so think before you post.

  • The information shared in these forums, by moderators and members, is designed to complement, not replace, the relationship between an individual and his/her own physician.

  • All members of these forums are, by default, not considered to be licensed medical providers. If otherwise, users must clearly define themselves as such.

  • Forums members must behave at all times with respect and honesty. Posting guidelines, including time-out and banning policies, have been established by the moderators of these forums. Click here for “Do I Have HIV?” posting guidelines. Click here for posting guidelines pertaining to all other POZ community forums.

  • We ask all forums members to provide references for health/medical/scientific information they provide, when it is not a personal experience being discussed. Please provide hyperlinks with full URLs or full citations of published works not available via the Internet. Additionally, all forums members must post information which are true and correct to their knowledge.

  • Product advertisement—including links; banners; editorial content; and clinical trial, study or survey participation—is strictly prohibited by forums members unless permission has been secured from POZ.

To change forums navigation language settings, click here (members only), Register now

Para cambiar sus preferencias de los foros en español, haz clic aquí (sólo miembros), Regístrate ahora

Finished Reading This? You can collapse this or any other box on this page by clicking the symbol in each box.

Author Topic: Molecule created that could 'kick and kill' HIV  (Read 3310 times)

0 Members and 1 Guest are viewing this topic.

Offline Ptrk3

  • Global Moderator
  • Member
  • Posts: 2,792
Molecule created that could 'kick and kill' HIV
« on: October 05, 2017, 07:00:14 pm »
Of course, if viable, this compound is years from clinical use, but it is something else to keep on the "radar" screen in HIV research.

From the October 5, 2017, edition of "Science Daily" (HIV/AIDS):

https://www.sciencedaily.com/releases/2017/10/171005141836.htm

From the article:

"...The latent HIV reservoir is very stable and can reactivate virus replication if a patient stops taking antiretroviral drugs for any reason," said Matthew Marsden, an assistant professor of medicine in the division of hematology oncology at the David Geffen School of Medicine at UCLA, and the study's lead author. "Our study suggests that there may be means of activating latent virus in the body while the patient is on antiretroviral drugs to prevent the virus from spreading, and that this may eliminate at least some of the latent reservoir."

To test the approach, the researchers gave antiretroviral drugs to mice that had been infected with HIV, and then administered a synthetic compound called SUW133, which was developed at Stanford, to activate the mice's dormant HIV. Up to 25 percent of the previously dormant cells that began expressing HIV died within 24 hours of activation.

With further development, the technique could lower the viral reservoir enough for people with HIV to be able to discontinue their anti-viral therapy, Marsden said.

SUW133 is based on bryostatin 1, a natural compound extracted from a marine animal called Bugula neritina. The research determined that the new compound is less toxic than the naturally occurring version...."


For research "geeks," here's the link to the technical research article (published  September 21, 2017, in PLOS (pathogens):

http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006575
HIV 101 - Basics
HIV 101
You can read more about Transmission and Risks here:
HIV Transmission and Risks
You can read more about Testing here:
HIV Testing
You can read more about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read more about HIV prevention here:
HIV prevention
You can read more about PEP and PrEP here
PEP and PrEP

Offline Jim Allen

  • Administrator
  • Member
  • Posts: 18,925
  • Twitter @JimAllenDublin
    • HIV Lessons
Re: Molecule created that could 'kick and kill' HIV
« Reply #1 on: January 20, 2022, 03:49:33 am »
Jan 10th 2022:

https://www.nature.com/articles/s41467-021-27647-0
Latency reversal plus natural killer cells diminish HIV reservoir in vivo

My summary:

In a recent study, 4 out of 10 mice showed no vial rebound that had been treated with ART and then a combination of SUW133 and an injection of PKC with follow-up injections of cytotoxic T white cells.
« Last Edit: January 20, 2022, 04:04:41 am by Jim Allen »
HIV 101 - Everything you need to know
HIV 101
Read more about Testing here:
HIV Testing
Read about Treatment-as-Prevention (TasP) here:
HIV TasP
You can read about HIV prevention here:
HIV prevention
Read about PEP and PrEP here
PEP and PrEP

Offline leatherman

  • Member
  • Posts: 8,023
  • Google and HIV meds are Your Friends
Re: Molecule created that could 'kick and kill' HIV
« Reply #2 on: January 20, 2022, 01:49:54 pm »
4 out of 10 mice showed no vial rebound
aww! I feel bad for those other 6 mice.  :'(
leatherman (aka mIkIE)

Boy, you're right in front of me
I need you to dance with me
Ooh, you're right in front of me
I'm gonna need your hands on me
- Darren Hayes, "Do you remember"

Offline Almost2late

  • Member
  • Posts: 1,447
Re: Molecule created that could 'kick and kill' HIV
« Reply #3 on: January 22, 2022, 03:37:34 am »
I wonder if they performed the treatment a second or third time would it work on the other 60%?

Offline Da2020

  • Member
  • Posts: 27
Re: Molecule created that could 'kick and kill' HIV
« Reply #4 on: February 20, 2022, 08:24:24 pm »
i wish i was one of the mice.

 


Terms of Membership for these forums
 

© 2022 Smart + Strong. All Rights Reserved.   terms of use and your privacy
Smart + Strong® is a registered trademark of CDM Publishing, LLC.