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Author Topic: SARS-CoV-2 mRNA Vaccination Exposes Latent HIV in Lab Studies  (Read 4507 times)

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Offline Da2020

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SARS-CoV-2 mRNA Vaccination Exposes Latent HIV in Lab Studies
« on: August 20, 2022, 08:51:03 pm »

For their research, the investigators, including co-first authors Eva Stevenson, Sandra Terry and Dennis Copertino, members of Dr. Jones’ lab, treated blood from individuals with HIV who were unvaccinated and had never had COVID-19 to the Pfizer-BioNTech or Moderna COVID-19 mRNA vaccine in test tubes. The Pfizer-BioNTech vaccine produced a greater release of HIV RNA.

Next, the researchers analyzed blood from individuals with HIV before COVID-19 vaccination and after each of two shots. In particular, they found that killer CD8+ T cells that target cells marked by an early gene product of HIV called Nef had released the protein granzyme B, a robust marker of recent attempts by the CD8+ T cells to kill HIV. This response, observed after the first shot, was correlated with a subsequent reduction in HIV RNA – suggesting some elimination of infected cells by the boosted CD8+ T cells.

Previous work by Dr. Jones and his team suggested that evaluating responses in Nef-specific CD8+ T cells might be a more useful method for measuring latency reversal than HIV RNA since the RNA ultimately may not be be turned into a protein that can be recognized by the immune system. The present study confirmed their hypothesis.

“Importantly, our lab studies found no evidence that exposing HIV reservoirs in an infected individual using mRNA vaccination would pose a risk of transmission to others,” said Dr. Jones. “We observed no appreciable level of HIV RNA in blood plasma following vaccine boost and expect continued ART would block any potential HIV replication.”[\quote]


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