Agent | Company | Trial Phase |
Rilviprine (TMC278) | Tibotec | IIb |
BILR 355 BS | Boehringer Ingelheim | II |
Calanolide A | Sarawak Medichem | II |
MIV-150 | Medivir/Chiron | II |
UK 453,061 | Pfizer | II |
RDEA806 | Ardea | I |
I have my hopes on KP-1461, the only antiretroviral in human use or testing that can eradicate HIV from laboratory cell cultures. I think that's a pretty big deal there's a drug right now that can eradicate HIV in cell cultures, no one else has done this, and its being tested on people as I speak, it said you might have to take it for 2 months, 4 months or 10 months. Personally I think you might have to take it for a year or 2 years I don't care if I have to take it for 5 years as long as I no longer have an HIV infection when I'm done. I'm no Scientist but some of the best HIV people came together to make this drug and I'm hopeful that this devil of a virus will stop ruining the life's of all us Beautiful people. May God Bless You All
KP was supposed to cause lethal mutations
while VRX496 is repeating somehow the same "error" to various existing mutations, by adding its lentiviral vector (RNA) to the DNA ?
My interest in raising this question is to estimate how much hopes can be put in the VRX496, as if the mechanism are not exactly the same, they are not very different.
Arms (http://clinicaltrials.gov/ct2/help/arm_group_desc) | Assigned Interventions (http://clinicaltrials.gov/ct2/help/interventions_desc) |
1: Experimental | Dietary Supplement: Probiotic Yogurt B: with various micronutrients 175g probiotic yogurt / day 25% RDA for each nutrient Dietary Supplement: Probiotic Yogurt A: Kaiser micronutrients 175g probiotic yogurt/ day 25% RDA for each nutrient Dietary Supplement: Probiotic yogurt C: with basic micronutrients 175g yogurt/ day 25% RDA for each nutrient |
2: Placebo Comparator | Dietary Supplement: Probiotic Yogurt D: Placebo -- no added micronutrients 175g/day probiotic yogurt |
I really don't get what this is about.
Prior attempts to filter blood have failed because the virus isn't just in the blood, its in your lymphatic system and in your tissues. Its not just floating around.
HIV hides from anti bodies and control cells that "command" antibodies, that why our immune system can't remove it.
If it lowers VL in the blood, I guess that's a good thing, however, what is really the impact on your T-Cells? HIV destroys the immune system. How would this actually help the body and your immune system recover? Especially if you can't clear it from the lymph nodes where much of this activity is occurring?
How reputable is Science Daily, with its adverts form the George Foreman Grill prominently displayed?
I need more.... Lots More...
I agree with you. Doesn't this sound like on of those gagets you can buy on the home shopping network for 19.95 and if you hurry to order they would include another hemopurifier in for free. ;D ;D
why is this not salvage therapy NOW for the 15 or is it 45 people in usa who die every day of aids
is it the fact that now that a huge majority of us have a 20 year plus horizon that we dont want to march and protest
why are we sending 50 billion over seas for aids when tens of thousands die each year in USA
why are we not acting up any more
where is the strong voices today?
..but very old, recycled bullshit..
I am a bit pessimistic as during our last meeting, VIRxSYS have more focused on the technical difficulties (to produce for e.g. such therapy) than on the result.
If I am able to listen in I am going to post some information on my blog about it.
big publicly traded french company just signed [...]
What has this "reasoning" got to do with the topic?
Posting it maybe against the pessimistic way of posting that some (typically veterans but not all) love to adopt. :)
Yeah, I know what you mean John (http://forums.poz.com/index.php?topic=20441.msg282132#msg282132). Loathsome people, all of them.
just today i was worry about what would happen to me personally ten years from now if treatment failure ever happened
http://www.aidsmeds.com/archive/currentNews_1667.shtml
Unfortunately these news do not talk about any of the studies posted just above..
Gee, maybe that's why he posted the link - additional information. ::)
Coughing.. Maybe ..
Green Tea
PS: You ought to have these cross-eyed looked at Ann.
I can't wait for Q1 09.
Green Tea
PS: You ought to have these cross-eyed looked at Ann.
(http://img124.imageshack.us/img124/5296/imagessw6.jpg)
Oh I have, John, I have. Doc said, "you've been reading the research forum at AIDSmeds again, haven't you."
Same symptom. But might be cured.
Cured? Hallelujah!
PRAISE BE! TESTIFY!
(http://img93.imageshack.us/img93/7932/phillyzf2.jpg)
At least hijacking is
Hi there,
I just take the opportunity of this thread to say goodbye to all the nice people here.
Nothing else to say than thanks and wishes you all to get the cure !
Keep Well, Be Strong
John
NOTE: I might read sometime
--------------- THE END -----------
even after swearing that you were bidding us farewell.
Disclaimer: I'm a physicist, not a physician nor an aids scientist.
Take my postings with a grain of salt.
Comment about my project
Use the email below if you are willing to contribute to an "open source" project aiming to transform studies in a way that they can be re-used to perform for e.g cross-studies.
This project is supported by a website allowing registered users to access the studies repository, and/or to contribute adding new studies following a well defined path and standard.
The aim of the association behind this website is to (short list):
- define the standards/process/tool to follow for these studies to be published so they can be reused.
- create tools to manipulate these data, such as performing cross-studies (and so establish new conclusions), highlighting contradicting/confirming results, etc.
- Next step: implement a procedure identify missing studies, inventory existing studies, etc. to work in a global effort
In exchange of their contributions (but optional), researchers and practitioners will be able to query the database for free of course.
And this could be useful for them, for e.g the ID docs:
Instead of having to read research all the time to remain cutting edge, they can access these research easily and get as such clues on directions to investigate (mainly to prescribe a combo for e.g).
This hopes is based on the conviction is that ID Doc use labs to diagnose you, and studies to choose combos.
So if a study is not done, or if the ID doc is missing a study, he just won't treat someone on the best possible way.
Accessing such database will contribute to highlight the info that could potentially be needed by a practitioner, and maybe by those of them designing new studies.
In more, contradicting, confirming studies can be highlighted, as well as hopefully new conclusions (e.g. for the Swiss study).
The description I am doing here of this project will very probably, if not certainly, evolve.
But the main goal is to synchronize as much as possible the global research. They haven't wait for such initiative to exists, but if this project could help 1 doc then it's already a god reason to work on it.
Now this goal is high. Impossible without the contribution of others. I am not enough skilled to do it all by my own. So what matter the most is who is contributing to this project.
The association will have to work closely with others associations, organizations, scientists, docs, etc and it is, as such, it is definitely a long term and very difficult effort.
But it seems necessary to me.
Regards,
John
pozlifeattitude@yahoo.com
What??
Is this YOUR study or are you just pointing people to some other person's study?The answer is in the initial post.
I think you are missing a bit of an explanation as to why you have posted this.You can't succeed alone
I, for one, would never simply send an email message to an address I have no knowledge about and a fairly incomplete accounting by you.Your choice. You are Welcome.
Also, you clearly have an incomplete view on how a combo is prescribed.
In addition to being up on the science, the doc should perform more testing (testing is NOT just for diagnosis of HIV)
to look for any resistance,
he/she should take the patient's desires into account,Out of the scope of the project.
should look at other medications you are on,Studies do that.
your lifestyle (i.e. sustiva might not work with your schedule or the need for food with Reyataz might not work), etc, etc.Out of the scope of this project, etc, etc.
In other words -- the scientific studies that seem to consume your every waking hour, are but one variable here - they are not the be all and end all.
You must remember (when your time for medication comes), that you still have your life to live,
so what a study says is "best" may not, in fact, be the best at all for your circumstance.
I would be glad to be banned :)
Take Care All, Be Strong
May God Bless You !
Cheers,
John
1) Is it possible to create steriles CD4s OR some kind of CD4s clones with just the envelope
(receptors CCR5 / CXCR4) so the virus could bind to them without being able to reproduce ?
2) Does the virus have an electrical charge (+ or -) ?
If so, could for e.g. a magnetic field force the virus to exit from the latent reservoirs and so be exposed to the drugs ?
Drug class | Phase III | Phase II |
Entry inhibitor (CCR5) | Vicriviroc | PRO 140 |
Entry inhibitor (CD4) | TNX-355 | |
Integrase inhibitor | Elvitegravir | |
Maturation inhibitor | Bevirimat | |
NNRTI | Rilpivirine | |
NRTI | Apricitabine | Racivir, Elvucitabine |
This article didn't mention for e.g. the stems cells (Dr Hutter), as a possible path to a cure.
A therapeutic vaccine to inhibit the spread of HIV will be available within five years, according to a Nobel Prize-winning scientist who helped discover the virus.
Luc Montagnier, director of the World Foundation for AIDS Research and Prevention, said he thinks it is "a matter of four to five years" before such a vaccine is developed.
[...]
"Our job, of course, is to find complementary treatment to eradicate the infection. I think it's not impossible to do it within a few years," Montagnier said in Stockholm, according to Reuters.
[...]
The French scientist did not explain why he believes the discovery will be made in that specific time frame.
Generic Name | Brand Name |
Isosorbide dinitrate | DILATRATE-SR, ISORDIL, SORBITRATE |
Isosorbide mononitrate | IMDUR, ISMO, MONOKET |
Nitroglycerin | MINITRAN, NITRO-BID, NITRO-DUR, NITROSTAT, TRANSDERM-NITRO |
Generic Name | Brand Name |
Doxazosin** | CARDURA** |
Prazosin* | MINIPRESS* |
Terazosin* | HYTRIN* |
Tamsulosin** | FLOMAX** |
Alfuzosin*** | UROXATRAL*** |
Generic Name | Brand Name |
Amprenavir | AGENERASE |
Aprepitant | EMEND |
Atazanavir | REYATAZ |
Clarithromycin** | BIAXIN** |
Conivaptan | VAPRISOL |
Cyclosporine | NEORAL, SANDIMMUNE |
Darunavir | PREZISTA |
Dasatinib | SPRYCEL |
Delavirdine | RESCRIPTOR |
Diltiazem** | CARDIZEM, CARDIZEM CD, DILACOR XR, TIAZAC** |
Erythromycin | EES, ERYTHROCIN |
Fluconazole | DIFLUCAN |
Fluvoxamine** | LUVOX** |
Fosamprenavir | LEXIVA |
Grapefruit Juice | - |
Imatinib | GLEEVEC |
Indinavir | CRIXIVAN |
Itraconazole* | SPORANOX* |
Ketoconazole | NIZORAL |
Lapatinib | TYKERB |
Mifeprestone | MIFEPREX |
Nefazodone* | SERZONE* |
Nelfinavir | VIRACEPT |
Posaconazole | NOXAFIL |
Quinupristin | SYNERCID |
Ritonavir | NORVIR |
Saquinavir | FORTOVASE, INVIRASE |
Telithromycin* | KETEK* |
Troleandomycin | TAO |
Verapamil | CALAN, CALAN SR, COVERA-HS, ISOPTIN, ISOPTIN SR, VERELAN |
Voriconazole | VFEND |
Zafirlukast* | ACCOLATE* |
Generic Name | Brand Name |
Aminoglutethimide | CYTADREN |
Bosentan | TRACLEER |
Carbamazepine | CARBATROL, TEGRETOL |
Dexamethasone | DECADRON, HEXADROL, MYMETHASONE |
Efavirenz | SUSTIVA |
Modafinil* | PROVIGIL* |
Nafcillin | NALLPEN, UNIPEN |
Nevirapine | VIRAMUNE |
Oxcarbazepine | TRILEPTAL |
Phenobarbital** | LUMINAL, SOLFOTON** |
Primidone | MYSOLINE |
Phenytoin | DILANTIN |
Rifabutin | MYCOBUTIN |
Rifampin | RIFADIN, RIMACTANE |
Rifapentine | PRIFTIN |
St. John’s wort | - |
Unprotected sex between long-term partners with HIV: no evidence for superinfection
what are the most promissing studies out there dealing with hiv eradication or a cure ? - am not talking preventive therapy here.
thanks
so the research at the "city of hope medical centre" is to eradicate the virus or curb it and prevent aids ? - see how can one word change the whole meaning of a certian study !
i thought i should mention KP1461 died a death a long time ago. I wonder if any company is doing any other research along the same lines though?
The return of KP-1461? Color me skeptical.
(http://img12.imageshack.us/img12/6855/virologyedu.th.jpg) (http://img12.imageshack.us/img12/6855/virologyedu.jpg) | The 10th International Workshop on Clinical Pharmacology of HIV Therapy has bene held in Amsterdam, The Netherlands, on 15-17 April, 2009. |
(http://img26.imageshack.us/img26/434/swazi.th.jpg) (http://img26.imageshack.us/img26/434/swazi.jpg) Swazi women preparing food | MBABANE, 15 April 2009 (IRIN) - Anecdotal evidence that entrenched cultural beliefs among Swazis actively encourage the spread of HIV/AIDS has been confirmed by a joint government and UN report. The study by UN the Population Fund (UNFPA) and Swaziland's Ministry of Health and Social Welfare - The State of the Swaziland Population - echoes warnings by local NGOs that "AIDS cannot be stopped unless there is a change in people's sexual behaviour." |
(http://img18.imageshack.us/img18/2981/bonewomen.th.jpg) (http://img18.imageshack.us/img18/2981/bonewomen.jpg) | Bone loss (osteopenia or the more severe osteoporosis) is common in people with HIV, although it remains unclear whether this is due to HIV infection itself, antiretroviral drugs such as tenofovir (Viread, also in the Truvada and Atripla combination pills), the normal aging process as HIV positive people survive longer, or some combination of factors. Decreased bone mineral density (BMD) occurs when the activity of osteoblasts (cells that build new bone tissue) and osteoclasts (cells that re-absorb bone) gets out of balance, but the mechanisms underlying this imbalance in HIV positive people is not fully understood. |
(http://img520.imageshack.us/img520/6472/palmtree.jpg)Have fun John & thanks for the news !!!!
On leave few days.
Keep Well.
John
NATAP Raltegravir SWITCHMRK Study published Lancet
http://www.natap.org/2010/HIV/011410_01.htm
When do you think that they will find a cure to test on humans? five, ten, twenty years?! Or are they already testin on humans?
John's a very busy man and I certainly hope you are not patronizing him.???
Efavirenz (EFV)-based therapy is more effective than lopinavir/ritonavir (LPV/r)-based therapy in antiretroviral-naive HIV patients with "very advanced" infections, new research shows.
Full Text (http://www.medscape.com/viewarticle/716279)
Mode of antiviral action of silver nanoparticles against HIV-1
BACKGROUND: Silver nanoparticles have proven to exert antiviral activity against HIV-1 at non-cytotoxic concentrations, but the mechanism underlying their HIV-inhibitory activity has not been not fully elucidated. In this study, silver nanoparticles are evaluated to elucidate their mode of antiviral action against HIV-1 using a panel of different in vitro assays. RESULTS: Our data suggest that silver nanoparticles exert anti-HIV activity at an early stage of viral replication, most likely as a virucidal agent or as an inhibitor of viral entry. Silver nanoparticles bind to gp120 in a manner that prevents CD4-dependent virion binding, fusion, and infectivity, acting as an effective virucidal agent against cell-free virus (laboratory strains, clinical isolates, T and M tropic strains, and resistant strains) and cell-associated virus. Besides, silver nanoparticles inhibit post-entry stages of the HIV-1 life cycle. CONCLUSIONS: These properties make them a broad-spectrum agent not prone to inducing resistance that could be used preventively against a wide variety of circulating HIV-1 strains.
Full Text (http://www.ncbi.nlm.nih.gov/pubmed/20145735?dopt=Abstract)
medicalxpresswhile not quite a vaccine, this could be an interesting discovery to keep an eye on. Plus it would be nice to see other research than just a "vaginal gel" for it's delivery system.
Research finds HIV-killing compound (http://goo.gl/nJ4rX)
The ability of the synthetic compound known as “PD 404,182” to break apart the AIDS-causing virus before it can infect cells.