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Meds, Mind, Body & Benefits => Nutrition & HIV => Topic started by: bimazek on January 31, 2007, 03:50:36 am
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American Journal of Clinical Nutrition, Vol. 83, No. 4, 870-879, April 2006
© 2006 American Society for Nutrition
ORIGINAL RESEARCH COMMUNICATION
Vitamins C and E in adolescents and young adults with HIV infection 1,2,3
Charles B Stephensen, Grace S Marquis, Robert A Jacob, Laurie A Kruzich, Steven D Douglas and Craig M Wilson
1 From the US Department of Agriculture Agricultural Research Service, Western Human Nutrition Research Center at the University of California, Davis, Davis, CA (CBS and RAJ); the Department of Nutrition, University of California, Davis, CA (CBS and RAJ); the Department of Food Science and Human Nutrition, Iowa State University, Ames, IA (GSM and LAK); the Division of Allergy and Immunology, Joseph Stokes Jr Research Institute at The Children's Hospital of Pennsylvania, Philadelphia, PA (SDD); the Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA (SDD); and the Department of Pediatrics and Medicine, University of Alabama at Birmingham, Birmingham, AL (CMW)
Background: Oxidative stress during HIV infection may impair immune function, cause more rapid disease progression, and increase requirements for dietary antioxidants such as vitamins C and E.
Objectives: The study had 2 principal objectives. The first was to ascertain whether HIV infection and immune activation were associated with lower plasma concentrations of ascorbate, urate, and {alpha}- and {gamma}-tocopherols and with total antioxidant status (TAS). The second objective was to ascertain whether these antioxidants were associated with protection against oxidative damage.
Design: This was a cross-sectional study involving 241 HIV-positive and 115 HIV-negative subjects aged 14–23 y. Subjects were primarily female (76%) and African American (70%), and 21% were Hispanic.
Results: Plasma ascorbate was significantly lower, but {gamma}-tocopherol and TAS were significantly higher in subjects with HIV infection when the analysis was adjusted for dietary intake and sex. Plasma {alpha}-tocopherol did not differ significantly by HIV status. Plasma {gamma}-tocopherol also was higher in subjects with oxidative damage than in those without such damage. More than 90% of subjects had adequate plasma concentrations for both ascorbate and {alpha}-tocopherol, although {alpha}-tocopherol concentrations were lower than expected on the basis of third National Health and Nutrition Examination Survey data.
Conclusions: Low plasma ascorbate concentrations in HIV-positive subjects suggest that vitamin C requirements are significantly higher in those with HIV infection. Plasma tocopherol concentrations were not depressed by HIV infection and may be maintained by compensatory mechanisms such as the activity of {alpha}-tocopherol transfer protein.
Key Words: Antioxidants • {alpha}-tocopherol • {gamma}-tocopherol • ascorbate • oxidative damage
http://www.ajcn.org/cgi/content/abstract/83/4/870