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Author Topic: HIV gene therapy - AGT103-T  (Read 17205 times)

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Offline Da2020

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Re: HIV gene therapy - AGT103-T
« Reply #50 on: December 26, 2022, 05:21:54 pm »
Link to the paper they have published


I think there was viral rebound in all the people. They are now trying to make changes to the trail protocol and start phase 2 where they start an ati quicker than they did in phase 1

Offline em

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Re: HIV gene therapy - AGT103-T
« Reply #51 on: January 31, 2023, 12:16:52 pm »
just received an email on this today

AGT Newsletter Graphics vol 16-2
Clinical Trial Progress Update
American Gene Technologies® has recorded data that meets the primary and secondary endpoints of its AGT103-T Phase 1 trial. The Phase 1 trial demonstrated that AGT103-T — an autologous T cell product that has been modified with the AGT103 lentiviral vector for HIV resistance — was well-tolerated in humans and that these enhanced T cells persist in the body, ready to respond to HIV. Data from this first-in-human study of AGT103-T has been published in Frontiers.


Having collected data from the Phase 1 clinical trial, we expect to submit the final Phase 1 trial report to the U.S. Food and Drug Administration (FDA) in 2023. American Gene is currently writing the Phase 2 protocol for FDA consideration to continue the clinical development of this potential HIV cure.

Does not seem encouraging or optimistic data disclosure.
If this had been major success I would think there would be more information.
Potential cure meaning in need of money for research and lots of time to get real results toward a cure.  Rather disappointing

Offline Jim Allen

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Re: HIV gene therapy - AGT103-T
« Reply #52 on: January 31, 2023, 12:52:59 pm »
Does not seem encouraging or optimistic data disclosure.
Potential cure meaning in need of money for research and lots of time to get real results toward a cure.  Rather disappointing

was well-tolerated in humans

With respect and not trying to sound harsh, but did you really expect much? You and I are not newbies to living with HIV, so we have heard the novel cure, new technology and approach speech a dozen times and more before during the Petri-dish stages and phase 1/2 human testing.

It's phase 1/2, making sure they don't kill the patients, and it sounds like it was well-tolerated, so they didn't kill anyone yet. As for the rest of the data, it's only a few weeks of interruption under a tiny sample of people. Even if AGT103-T gene therapy does nothing, you could have some people or all of them show no rebound under 4-5 months. 

If it gets into phase 2 and then phase 3 by then, data might be more interesting.
« Last Edit: January 31, 2023, 01:08:46 pm by Jim Allen »
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