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Author Topic: Twice-Daily Kaletra Better for Some Patients  (Read 1303 times)

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Offline Ihavehope

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Twice-Daily Kaletra Better for Some Patients
« on: March 07, 2007, 10:20:24 AM »
Twice-Daily Kaletra Better for Some Patients

March 6, 2007

By Tim Horn, Senior Writer & Editor

(AIDSmeds.com) - The results of an AIDS Clinical Trials Group (ACTG) study indicate that HIV-positive people beginning treatment with high viral loads may be better off taking Kaletra® (lopinavir/ritonavir) twice a day instead of once a day.
For people beginning HIV treatment for the first time, Kaletra-based treatment regimens are a popular option, dosed either once or twice a day.  Once-daily dosing requires taking four tablets every 24 hours; twice-daily dosing involves taking two tablets every 12 hours. 

A concern with all HIV treatment regimens is that people with high viral loads – generally defined as pre-treatment levels in excess of 100,000 – may face greater challenges keeping their viral loads undetectable compared to those with lower pre-treatment levels.  This has been a particularly important issue when evaluating simplified drug regimens, as some once-daily drugs and drug regimens may not achieve blood concentrations that are high enough to successfully control high pre-treatment viral loads. 

http://www.aidsmeds.com/articles/1667_11447.shtml
Infected: April 2005
12/6/06 - Diagnosed HIV positive
12/19/06 - CD4 = 240  22% VL = 26,300
1/4/07 - CD4 = 200 16% VL = ?
2/9/07 = Started Kaletra/Truvada
3/13/07 = CD4 = 386 22% VL ?

 


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