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Author Topic: NucleomaxX  (Read 6168 times)

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Offline Ihavehope

  • Member
  • Posts: 1,366
  • Yes, I'm a cry baby, AND WHAT?
NucleomaxX
« on: February 27, 2007, 01:25:18 PM »
There's been quite a bit of interest in this and speculation. I guess the form in which uridine is being studied in people with HIV is in this supplement from Europe called NucleomaxX -- that's a sugar cane extract. The rationale behind using uridine is that one side effect of mitochondrial damage might be a reduction in nucleoside production, and by giving uridine, which is a nucleoside, you're kind of, in a way, overcoming that deficiency that's created secondary to mitochondrial toxicity, and by overcoming this deficiency, perhaps you could reverse some of the lipoatrophic effects of the nucleosides.

So that's the theory. You know, theory and practice are often widely separated. The only study that I'm aware of to date that's produced really well controlled data was a small study that was reported by Jussi Sutinen from Helsinki, and this was reported at the lipodystrophy meeting that was held in Dublin last fall, and it was a very small study, but it was well done, randomized, double-blind placebo-controlled. I think there were about 10 subjects per group, and they were randomized to get this supplement, NucleomaxX, or a placebo for three months. In that three-month period, the subjects who were randomized to receive NucleomaxX had an increase in limb fat, combined arm and leg fat, that totaled [about 900 grams]. That's [almost two pounds] of an increase in limb fat over three months, and that magnitude of increase is greater than what had been seen in so-called switch studies and also what's been seen in the studies using the so-called glitazones.

So it's very promising. A couple of big caveats: First of all, it was a very small study and obviously needs to be studied further in larger groups of subjects. The other thing is that in addition to an increase in limb fat, there was an increase in intra-abdominal fat, and so, in the patients who received NucleomaxX. So it's not clear whether the effect of this supplement was to just put on fat all over non-selectively or whether this will wind up being something that can specifically reverse lipoatrophy, the loss of subcutaneous fat, but I think it's intriguing and definitely warrants further study.

Written by:

About Kathleen Mulligan, Ph.D.


Dr. Mulligan helped organize the first International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, the only medical conference focused entirely on body-shape changes in people with HIV. She is one of the key researchers working on trying to understand and treat the disorder. After receiving a Ph.D.
Infected: April 2005
12/6/06 - Diagnosed HIV positive
12/19/06 - CD4 = 240  22% VL = 26,300
1/4/07 - CD4 = 200 16% VL = ?
2/9/07 = Started Kaletra/Truvada
3/13/07 = CD4 = 386 22% VL ?

Offline mjmel

  • Member
  • Posts: 2,069
Re: NucleomaxX
« Reply #1 on: March 01, 2007, 07:26:20 AM »
my two cents:

1. The stuff is horrid to taste. No matter how much we tried to cover it the unique and nauseous taste still came through. Like a shot of yager that you'd swish instead of downing; extremely bitter.

2. Orders and shipping was interesting. Had to order it from England. Was a bit nervous doing the credit card transaction as it seemed I was ordering it from some sort of curiosity shoppe. No problems resulted from transactions, however. Oddly, when the parcel (box) arrived it had a shipping address from inside US.  ???  Wish I would have saved that address. Just found it interesting that I couldn't buy it in the US but apparently it's stocked here.......somewhere. It's kind of pricey too.

3. Conflicting data on the product. One study show this is good; another discredits it. That's why my partner and I decided to quit using it.
Well, the horrid taste did add to it's discontinued use, to be completely honest.

Just sharing my impressions from having tried it.
xxx,
Mike

Offline blondbeauty

  • Member
  • Posts: 1,784
Re: NucleomaxX
« Reply #2 on: March 01, 2007, 07:25:03 PM »
Nucleomax is Uridine. Uridine is available in a very cheap medication called Núcleo C.M.P. Forte but it is only recommended for neuralgia caused by: alcoholism, toxic effects, infections, etc. and for facial paralysis.
Here is a Link to Nucleo C.M.P. Forte: Available in pill form and for inyection.
 
NUCLEO CMP FORTE CAPS
Composición
Por cápsula 
          Citidin 5 monofosfato disódico (CMPsal disódica) 5 mg
          Uridin 5 difosfato disódico (UDP sal disódica)
          Uridin 5 monofosfato disódico (UMP sal disódica)
          equivalente a 1,330 mg. de Uridina
          Excipientes c.s
          Uridin 5 trifosfato trisódico (UTP sal trisódica)
 
Indicaciones y uso
INDICACIONES :

Afecciones Neuromusculares por deficiencia de los componentes del producto.


CONTRAINDICACIONES

No se conocen. A menos de que exista una alergia a cualquiera de los componentes.
 
Acciones Farmacológicas
Núcleo CMP Forte aporta los grupos fosfato necesarios en la unión de los monosacáridos con las ceraminas, para formar cerebrósidos y ácidos fosfatídicos que constituyen la esfingomielina y glicerofosfolípidos, componentes principales de la vaina de mielina, con lo que se consigue unas mayores propiedades tróficas para la maduración y regeneración axonal del tejido nervioso.

Se sabe que en la mayoría de las manifestaciones patológicas del sistema nervioso periférico, existe una degeneración nerviosa caracterizada fundamentalmente por una desmielinización, y que el proceso de regeneración requiere de una síntesis proteica - lipídica intensa

Núcleo CMP Forte contiene dos nucleótidos (CMP, UTP) de especial acción bioquímica en la síntesis de los ácidos nucleicos, de los lípidos ( fosfolípidos, lípidos nitrogenados ) y de las proteínas.
El Citidin monofosfato ( CMP ) interviene en estos procesos de síntesis, siendo el factor de transferencia indispensable para la formación de lípidos complejos ( lecitina, esfingomielina etc. ) componentes fundamentales del sistema nervioso en especial de las membranas celulares de la neurona y de la vaina de mielina

El uridin trifosfato ( UTP ) es un importante nucleótido que interviene como “transfer” de variados radicales, en procesos metabólicos diversos. como el metabolismo lipídico para formar lípidos complejos como los cerebrósidos y gangliósidos ya que su derivado el UDP se une a la galactosa formando cerámidos en el procesos de síntesis de cerebrósiodos; y a la acetil glucosamina produciendo UDP-acetilglucosamina la que reacciona con el fosfoenolpiruvato dando lugar a los ácidos sialico y neuranímico los que se integran a la molécula de gangliosidos

En consecuencia NUCLEO CMP aporta los grupos fosfato necesarios en la unión de los monosacáridos con las ceraminas, generando cerebrósidos y ácidos fosfatídicos que constituyen la esfingomielina y glicerofosfolípidos, componentes principa
Uso terapéutico
Antidesmielinizante antálgico antineurítico
Presentación
          Envase conteniendo 20 cápsulas.
 
Interacciones con otros medicamentos
INTERACCIONES
No se conocen.

INCOMPATIBILIDADES
No se han referido

 
Reacciones adversas
REACCIONES ADVERSAS

No se han descrito , pero si se produce cualquier reacción adversa achacable a la toma del medicamento consulte a su médico o farmacéutico.
 
Dosis y vías de administración
DOSIS Y VIA DE ADMINISTRACION

NÚCLEO CMP Forte cápsulas se administra por vía oral.

Adultos: 1 ó 2 cápsulas 2 veces al día.
Niños : 1 cápsula 2 veces al día según criterio médico
TRATAMIENTO EN CASO DE SOBREDOSIS
Dada la escasa toxicidad del preparado no se prevé la intoxicación ni aún la accidental.
 
Advertencias
PRECAUCIONES

No se han referido.
Para la aplicación del inyectable: Introducir la totalidad del contenido de la ampolla disolvente en la ampolla liofilizada, agitar hasta disolver totalmente el contenido de ésta, inyectarla solo por vía intramuscular.
Carcinogenicidad y Mutagenicidad.- No se han referido
Embarazo y Lactancia: No se han referido contraindicaciones de uso en el embarazo, no obstante, se aconseja que la pauta de administración sea establecida por el medico.
Pediatría.- No se han referido
Geriatría.- No se han referido

ADVERTENCIAS
No se han referido


[attachment deleted by admin]
« Last Edit: March 01, 2007, 07:30:06 PM by blondbeauty »
The only member in these forums approved by WINBA: World International Nail and Beauty Association.
Epstein Barr +; CMV +; Toxoplasmosis +; HIV-1 +.
Counts when starting treatment:
V.L.:80.200 copies. CD4: 25%=503
Started Sustiva-Truvada 14/August/2006
Last V.L.count (Oct 2013): Undetectable
Last CD4 count (OCT 2013): 52%= 933

 


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