Meds, Mind, Body & Benefits > Nutrition & HIV

Garlic?

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Teresa:
I read in another thread that garlic extract wasnt good for people with HIV. What about garlic salt or garlic powder?

Thanks
Teresa

Jacques:
Hi Teresa,

According to the "Check my meds" section of this site, there is an interaction between PIs and garlic supplements. See below:


--- Quote ---GENERALLY AVOID: Co-administration with garlic supplements may decrease the plasma concentrations of saquinavir and possibly other protease inhibitors (PIs). The exact mechanism is unknown but may involve induction of CYP450 3A4 metabolism and/or P-glycoprotein transport in the intestine by certain component(s) of garlic. In nine healthy, HIV-negative volunteers, investigators from the National Institutes of Health found that pretreatment with a garlic supplement (GarliPure Maximum Allicin Formula twice daily for 3 weeks) reduced the mean peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) of saquinavir (soft gelatin capsule 1200 mg 3 times daily for 10 doses during the last 4 days of garlic supplementation) by 54% and 51%, respectively, compared to baseline when saquinavir was administered alone. The effects appear to be sustained, since saquinavir Cmax and AUC returned to just 61% and 65% of baseline, respectively, after a 10-day washout period. Whether and how dietary garlic or other formulations of garlic supplement may affect saquinavir pharmacokinetics are currently unknown. It is also uncertain if and to what extent the interaction may occur with other PIs, which are also substrates of CYP450 3A4. MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, garlic supplements should preferably be avoided in patients treated with PIs, particularly if they are using saquinavir as the sole PI in their antiretroviral regimen. Patients should be advised to consult with their caregivers before using any herbal or alternative medicines.

--- End quote ---
.

But I also saw on HIV nutrition sites that raw or garlic powder  in cooking are okay if used with moderation.

Jacques

J.R.E.:
Hello Teresa,

And here are a couple links from the archived forums :

http://www.aidsmeds.com/Fusetalk/messageview.cfm?catid=6&threadid=19179&FTVAR_MSGDBTABLE=


http://www.aidsmeds.com/Fusetalk/messageview.cfm?catid=10&threadid=23704&FTVAR_MSGDBTABLE=


Ray

Markmt:
Hi Teresa/Jacques/Ray,

thnks for the refresher...I still doubt when I use garlic, good to read past posts for assurance :)

hugs

mark

Teresa:
Thanks for all the info guys.
I just love this place..always someone here that will answer my questions.

Hugs
Teresa

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