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Author Topic: HIV's weakness/soft spot...and our next target  (Read 1884 times)

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Offline terpie82

  • Member
  • Posts: 92
HIV's weakness/soft spot...and our next target
« on: February 20, 2007, 10:52:47 AM »
A recent finding from Kwong's group out of NIAID (institute out of NIH, Bethesda) reveal that HIV's glycoprotein gp120 has a conserved domain, despite other parts of the virus which are notorious for mutations, evading antibodies, and development of a successful vaccine. With this conserved domain comes a new target for vaccine development that will potentially affect all/many viruses, despite the strains/mutations. I've included a link to the article and Tim Horn's summary. All I can say is...it's about G*& damn time  :)

http://www.nature.com/nature/journal/v445/n7129/abs/nature05580.html
http://poz.com/articles/761_11308.shtml
Diagnosed in 2003
UD since 2004 and >35% (with one blip)

Offline allopathicholistic

  • Member
  • Posts: 3,258
Re: HIV's weakness/soft spot...and our next target
« Reply #1 on: February 20, 2007, 11:00:43 AM »
I asked the universe for good news this morning and this is what I'm given. Thank you terpie. Thank you to the LTNP's and all involved. Oh goodness, tears are in my eyes at the moment cuz I'm a hyperemotional queen this morning and just really really grateful to hear positive news

VIVE LA GOOD NEWS LOL  :D

Offline Ihavehope

  • Member
  • Posts: 1,366
  • Yes, I'm a cry baby, AND WHAT?
Re: HIV's weakness/soft spot...and our next target
« Reply #2 on: February 20, 2007, 11:44:52 AM »
Cool. Hope it works. But I ain't opening the champagne bottle till it is available and proof that the clinical trials are successful.

Infected: April 2005
12/6/06 - Diagnosed HIV positive
12/19/06 - CD4 = 240  22% VL = 26,300
1/4/07 - CD4 = 200 16% VL = ?
2/9/07 = Started Kaletra/Truvada
3/13/07 = CD4 = 386 22% VL ?

Offline OzPaul

  • Member
  • Posts: 410
  • a very blessed 29 year ltnp
Re: HIV's weakness/soft spot...and our next target
« Reply #3 on: February 20, 2007, 05:28:45 PM »
Hi Minh


Thanks for letting us know about the latest findings. Thank to Tim as well. It's really great to know that some of the research that us LTNP's  are involved in is starting to show some good results. One step at a time and perhaps before too much longer there may even a be a therapeutic vaccine  ;D Then who knows ?

Cheers
Paul

Offline poet

  • Member
  • Posts: 934
  • Poet living and working in Central Maine
Re: HIV's weakness/soft spot...and our next target
« Reply #4 on: February 20, 2007, 05:40:07 PM »
Thanks for bringing this to our attention!  Best, Win
Winthrop Smith has published three collections of poetry: Ghetto: From The First Five; The Weigh-In: Collected Poems; Skin Check: New York Poems.  The last was published in December 2006.  He has a work-in-progress underway titled Starting Positions.

Offline HIVworker

  • Member
  • Posts: 918
  • HIV researcher
Re: HIV's weakness/soft spot...and our next target
« Reply #5 on: February 20, 2007, 07:12:59 PM »
Wasn't this already brought up in the research section of this forum?
NB. Any advice about HIV is given in addition to your own medical advice and not intended to replace it. You should never make clinical decisions based on what anyone says on the internet but rather check with your ID doctor first. Discussions from the internet are just that - Discussions. They may give you food for thought, but they should not direct you to do anything but fuel discussion.

Offline jkinatl2

  • Member
  • Posts: 6,007
  • Doo. Dah. Dipp-ity.
Re: HIV's weakness/soft spot...and our next target
« Reply #6 on: February 21, 2007, 12:08:26 AM »
Wasn't this already brought up in the research section of this forum?

Lika anyone goes there. This is about Living With HIV, not learning about it.

"Many people, especially in the gay community, turn to oral sex as a safer alternative in the age of AIDS. And with HIV rates rising, people need to remember that oral sex is safer sex. It's a reasonable alternative."

-Kimberly Page-Shafer, PhD, MPH

Welcome Thread

Offline OzPaul

  • Member
  • Posts: 410
  • a very blessed 29 year ltnp
Re: HIV's weakness/soft spot...and our next target
« Reply #7 on: February 21, 2007, 01:16:01 AM »
Hey Jonathan

It's good to have you back  ;D

I need to say something however. Those of us who are LTNP's, and there are about 5 here at the Forums,  do 'Live with'  HIV. Most of here are enrolled at the NIH study that the article in POZ magazine mentioned.

 We are not, as I'm sure you know, not merely research tools (aka lab rats) but real living people who are in our way affected by HIV ( stigma, alienation, job discrimation, unable to get health insurance, etc.). I was tested positive in 1985 and have 'Lived with' HIV every day since then.

just sayin
Paul

« Last Edit: February 21, 2007, 03:41:44 AM by OzPaul »

Offline zephyr

  • Member
  • Posts: 459
    • Zephyr L.T.N.P. Foundation, Inc.
Re: HIV's weakness/soft spot...and our next target
« Reply #8 on: February 21, 2007, 01:04:24 PM »
Hello to my 'lil' bro, Minh!

Thanks for posting this update on the NIAID research and their findings, honey. I appreciate any and all alerts to current work, and when they come from you, I certainly pay attention.

As for where the data gets posted, I could give a hoot. (Kudos to jonathan on his response).

I have always maintained that the research that is on-going will provide us with clues as time progresses, and each day I continue to hold good thoughts for and about each individual who take the time to participate in the studies, as well as for the professionals devoted to the work toward discovery.

Have a wonderful day, folks.

Zeph
"It is character that communicates most eloquently."

Offline Robert

  • Member
  • Posts: 2,639
Re: HIV's weakness/soft spot...and our next target
« Reply #9 on: February 21, 2007, 01:47:02 PM »
thanks for the posting Minh.  I'm not sure what it means.  I read your interpretation, Tim's and the one in Nature.  They are all just a little bit too over the top for me.  I try to understand these things and I just can't  get a handle on them.  So that is why I like it when you post these in the "Living" section.  I know they're really important and they're meaningful to my well-being and I love the fact that you care so much of my (read "our") health that you print them here.

And, by the way, since you're not coming to Oakland in Oct, how about SF in September?  You can lead the Saturday Morning Seminar on how "HIV's glycoprotein gp120 has a conserved domain,".  Or any other subject of your choosing as long as you're there!!

robert
..........

Offline manchesteruk

  • Member
  • Posts: 630
Re: HIV's weakness/soft spot...and our next target
« Reply #10 on: February 21, 2007, 01:51:43 PM »
Thanks for posting this Minh.  I have to say though i'm with Robert i've read the articles but they don't make a lot of sense in my head!  It's good to see some more findings coming from the LTNP research this certainly isn't the first one i've heard about.
Diagnosed 11/05

"Life is too important to be taken seriously" Oscar Wilde

 


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