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Author Topic: Maraviroc  (Read 2040 times)

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Offline Jeffreyj

  • Member
  • Posts: 1,403
Maraviroc
« on: February 13, 2007, 09:26:43 PM »
I know I may be overly  optimistic, but here may be more good news on the HIV drug front.  Go Pfizer, Go!

http://money.cnn.com/2007/02/13/news/companies/bc.pfizer.maraviroc.reut/index.htm?section=money_email_alerts
Positive since 1985

Offline koi1

  • Member
  • Posts: 713
Re: Maraviroc
« Reply #1 on: February 13, 2007, 10:22:44 PM »
Hey Guy,

No, hope is always good. So you keep finding the good news for us.

rob
diagnosed on 11/20/06 viral load 23,000  cd4 97    8%
01/04/07 six weeks after diagnosis vl 53,000 cd4 cd4 70    6%
Began sustiva truvada 01/04/07
newest labs  drawn on 01/15/07  vl 1,100    cd4 119    7%
Drawn 02/10/07
cd4=160 viral load= 131 percentage= 8%
New labs 3/10/07 (two months on sustiva truvada
cd4 count 292  percentage 14 viral load undetectable

Offline Life

  • Member
  • Posts: 2,388
  • Member 2005
Re: Maraviroc
« Reply #2 on: February 13, 2007, 10:28:09 PM »
Jeff, everytime you find this stuff, my heart sings..   Never loose sight of the fact that there are people out there striving for better treatments for ALL OF US....   Face value...

Love

Eric

Offline Ihavehope

  • Member
  • Posts: 1,366
  • Yes, I'm a cry baby, AND WHAT?
Re: Maraviroc
« Reply #3 on: February 13, 2007, 10:34:27 PM »
Jeff

It's fantastic news!! Jeff's a great guy he always has a positive attitude! A new hope for those running out of treatment options! Hooray!

Al
Infected: April 2005
12/6/06 - Diagnosed HIV positive
12/19/06 - CD4 = 240  22% VL = 26,300
1/4/07 - CD4 = 200 16% VL = ?
2/9/07 = Started Kaletra/Truvada
3/13/07 = CD4 = 386 22% VL ?

Offline StrongGuy

  • Member
  • Posts: 492
Re: Maraviroc
« Reply #4 on: February 13, 2007, 11:58:34 PM »
That is great news...

Plus the integrase inhibitors are slated to come out soon too and my doc is downright giddy about the prospect of this class having a huge impactf. We shall see but hope is good...pipeline looks good this year.
"Get your medical advice from Doctors or medical professionals who you trust and know your history."

"Beware of the fortune teller doom and gloomers who seek to bring you down and are only looking for company, purpose and validation - not your best physical/mental interests."

"You know you all are saying that this is incurable. When the real thing you should be saying is it's not curable at the present time' because as we know, the great strides we've made in medicine." - Elizabeth Edwards

Offline Jeffreyj

  • Member
  • Posts: 1,403
Re: Maraviroc
« Reply #5 on: February 14, 2007, 06:10:43 AM »
Thanks guys! Got to keep digging..One of these is gonna hit I just know it!
Positive since 1985

Offline Central79

  • Member
  • Posts: 527
Re: Maraviroc
« Reply #6 on: February 14, 2007, 09:54:11 AM »
Here's some more on the maraviroc story:

http://www.medicalnewstoday.com/medicalnews.php?newsid=63003

I think this class of drugs is going to be a lifeline for treatment experienced HIVers. And Jesse James is slamming big pharma for our cure! I'm pretty excited by radioimmunotherapy to kill HIV infected cells:

http://www.aidsmap.com/en/news/E53870AA-E248-4CD7-BFFF-D2004E3F6923.asp

I hope they will start some human trials soon.

Matt.
Diagnosed January 2006
26/1/06 - 860 (22%), VL > 500,000
24/4/06 - 820 (24.6%), VL 158,000
13/7/06 - 840 (22%), VL 268,000
1/11/06 - 680 (21%), VL 93,100
29/1/07 - 1,020 (27.5%), VL 46,500
15/5/07 - 1,140 (22.8%), VL not done.
13/10/07 - 759 (23.2%), VL 170,000
6/11/07 - 630 (25%), VL 19,324
14/1/08 - 650 (21%), VL 16,192
15/4/08 - 590 (21%), VL 40, 832

Offline Jeffreyj

  • Member
  • Posts: 1,403
Re: Maraviroc
« Reply #7 on: February 14, 2007, 05:36:49 PM »
Matt,
Thanks for the info. This sounds really exciting! It could really help those of us who are on their last cocktail(like myself). This really could be huge!
Positive since 1985

Offline pozguy75

  • Member
  • Posts: 1,239
    • POZitively Speaking
Re: Maraviroc
« Reply #8 on: February 14, 2007, 06:36:51 PM »
Hey Guys...

I was on Maraviroc...in the study. It worked great but, it caused my tropism to change from CCR5 receptor to CCR4X...which made the drug no longer effective for me. I was on it for 18 months, and it stopped working for me.

But, it may be a good option for those who are not naive to treatment and this could be the last option for some...

It's good to have the hope, but as one person who was on it...I just caution to have your tropisms checked with your regular bloods.
Dx 2005
ATRIPLA

Offline Central79

  • Member
  • Posts: 527
Re: Maraviroc
« Reply #9 on: February 15, 2007, 04:05:18 AM »
Hey Guys...

I was on Maraviroc...in the study. It worked great but, it caused my tropism to change from CCR5 receptor to CCR4X...which made the drug no longer effective for me. I was on it for 18 months, and it stopped working for me.


I'm guessing you took it as monotherapy, rather than as part of a HAART regemin? The trial running in the UK means you have to be treatment naive. I think this probably ups the chances of the virus switching... Hopefully maviroc will have more staying power as part of an effective HAART regimen where VL is low or undetectable.
Diagnosed January 2006
26/1/06 - 860 (22%), VL > 500,000
24/4/06 - 820 (24.6%), VL 158,000
13/7/06 - 840 (22%), VL 268,000
1/11/06 - 680 (21%), VL 93,100
29/1/07 - 1,020 (27.5%), VL 46,500
15/5/07 - 1,140 (22.8%), VL not done.
13/10/07 - 759 (23.2%), VL 170,000
6/11/07 - 630 (25%), VL 19,324
14/1/08 - 650 (21%), VL 16,192
15/4/08 - 590 (21%), VL 40, 832

Offline aupointillimite

  • Member
  • Posts: 3,229
  • FUS DO RAH!
Re: Maraviroc
« Reply #10 on: February 15, 2007, 05:13:46 AM »
I'm guessing you took it as monotherapy, rather than as part of a HAART regemin? The trial running in the UK means you have to be treatment naive. I think this probably ups the chances of the virus switching... Hopefully maviroc will have more staying power as part of an effective HAART regimen where VL is low or undetectable.

I can't speak on Jeromy's behalf... but I know of no drug trial for HIV that essentially amounts to monotherapy (except for that Kaletra one a few years back).

Before Maraviroc was even named and entry-inhibitors were just a gleam in their daddies' eyes I'd heard this mentioned as a possibility... that CCR5-receptor tropic HIV would mutate to become CCR4X-tropic.  This isn't a surprise... from what I've read, this was predicted to happen.

But to reiterate... I can't imagine that it was given as monotherapy... even in clinical trials.
« Last Edit: February 15, 2007, 05:17:57 AM by aupointillimite »
Your tastebuds can't repel flavor of this magnitude!

Offline Central79

  • Member
  • Posts: 527
Re: Maraviroc
« Reply #11 on: February 15, 2007, 12:32:00 PM »
No - absolutely. But they were testing it in treatment naive patients who had a reasonable CD4 count, i.e. they didn't need to be on HAART at alll.

The trial run by Pfizer in the UK involved treatment-naive patients randomised to various doses of maraviroc or a placebo as a monotherapy, with positive results. I'm not sure whether this rules out the people in the study using maraviroc in the future. Maybe the tropism switches back after stopping treatment like some mutations to nevarapine die out if you stop using it (like in pregnancy).

Here's the link on maraviroc. The bit about monotherapy is in the middle of the third paragraph.

http://www.aidsmap.com/en/docs/1691F01C-B131-47F3-813B-6337A634CAAB.asp

So how about it Jeremy, where you on anything else?

Matt.
Diagnosed January 2006
26/1/06 - 860 (22%), VL > 500,000
24/4/06 - 820 (24.6%), VL 158,000
13/7/06 - 840 (22%), VL 268,000
1/11/06 - 680 (21%), VL 93,100
29/1/07 - 1,020 (27.5%), VL 46,500
15/5/07 - 1,140 (22.8%), VL not done.
13/10/07 - 759 (23.2%), VL 170,000
6/11/07 - 630 (25%), VL 19,324
14/1/08 - 650 (21%), VL 16,192
15/4/08 - 590 (21%), VL 40, 832

Offline StrongGuy

  • Member
  • Posts: 492
Re: Maraviroc
« Reply #12 on: February 15, 2007, 06:03:19 PM »
I can't speak for Jeromy but I do seem to remember him posting that he was on once-daily dosing of Maraviroc (in combination with other drugs) and had a slight viral load breakthrough after some months and then was put on twice daily (as was all other participants in the study - which was reported in the news).

I have no way of knowing if this was the cause of resistance or tropism, but something to keep in mind and I'm sure he can explain further.

Anyway my primary reason for posting was this article that caught my eye that just came across the wires today on the Integrase inhibitors, Mariviroc, drug pipeline and promising advances for highly treatment experienced patients. As with anything, I take it with a grain of salt but it's good to be "in the know" nonetheless. Here's a snip of the article and the link

http://www.bloomberg.com/apps/news?pid=20601103&sid=a4bJZCeWUnGc&refer=news

Quote
Merck, Pfizer HIV Drugs May Spark a Second Revolution (Update1)

By John Lauerman and Allan Dodds Frank

Feb. 15 (Bloomberg)

 Previously Unseen Weapons

The new therapies -- including Pfizer's experimental maraviroc and Merck's MK-0518, both now in late-stage testing -- blunt HIV's ability to evade drugs through rapid, constant mutation. They hit the virus with previously unseen weapons that may give drugmakers six or more years in which to develop even more powerful drugs, infectious disease doctors say.

``These drugs will provide additional generations of therapy and give us time to find more new drugs and potential targets,'' said Daniel Kuritzkes, a Harvard University researcher who treats HIV patients at Brigham and Women's Hospital in Boston. ``It is really a major advance.''

The new treatments can also be vital in helping keep the disease under control as U.S. officials this month begin a push to make HIV testing routine in emergency rooms, clinics and doctor's offices, potentially adding as many as 100,000 newly diagnosed patients. Almost one in five of those patients might be infected with strains able to beat at least one of the major types of drugs that currently keep AIDS at bay, experts say.

HIV attacks the immune system, leaving the body vulnerable to the infections and tumors that make AIDS, or acquired immune deficiency syndrome, lethal.


« Last Edit: February 15, 2007, 06:06:08 PM by StrongGuy »
"Get your medical advice from Doctors or medical professionals who you trust and know your history."

"Beware of the fortune teller doom and gloomers who seek to bring you down and are only looking for company, purpose and validation - not your best physical/mental interests."

"You know you all are saying that this is incurable. When the real thing you should be saying is it's not curable at the present time' because as we know, the great strides we've made in medicine." - Elizabeth Edwards

Offline Central79

  • Member
  • Posts: 527
Re: Maraviroc
« Reply #13 on: February 16, 2007, 11:12:49 PM »
Good article. For once, I think this isn't just wolly optimism. The data on these drugs is good and solid and they seem to show real efficacy for HIVers resistant to other classes of HIV drugs. I think that in time, they will make their way into standard triple HAART therapy as maybe being superior to current classes. I wonder what their side effects profile is going to be like?
Diagnosed January 2006
26/1/06 - 860 (22%), VL > 500,000
24/4/06 - 820 (24.6%), VL 158,000
13/7/06 - 840 (22%), VL 268,000
1/11/06 - 680 (21%), VL 93,100
29/1/07 - 1,020 (27.5%), VL 46,500
15/5/07 - 1,140 (22.8%), VL not done.
13/10/07 - 759 (23.2%), VL 170,000
6/11/07 - 630 (25%), VL 19,324
14/1/08 - 650 (21%), VL 16,192
15/4/08 - 590 (21%), VL 40, 832

Offline StrongGuy

  • Member
  • Posts: 492
Re: Maraviroc
« Reply #14 on: February 17, 2007, 12:30:45 AM »
I was actually looking through my bookmarks yesterday for some specific info on the sides and all I could find for the Integrase inhibitors was "well tolerated." That doesn't usually mean much because one person's "well tolerated" is another person's "not so well-tolerated."

I do remember reading somewhere that the sides in one of the studies for one of the integrase inhibitors was "same as placebo," which is usually a good sign but I can't find the article so don't quote me on it. My usually good memory is failing me.

Mike ;)
« Last Edit: February 17, 2007, 12:33:40 AM by StrongGuy »
"Get your medical advice from Doctors or medical professionals who you trust and know your history."

"Beware of the fortune teller doom and gloomers who seek to bring you down and are only looking for company, purpose and validation - not your best physical/mental interests."

"You know you all are saying that this is incurable. When the real thing you should be saying is it's not curable at the present time' because as we know, the great strides we've made in medicine." - Elizabeth Edwards

Offline Central79

  • Member
  • Posts: 527
Re: Maraviroc
« Reply #15 on: February 20, 2007, 08:25:55 AM »
My usually good memory is failing me.

Mike ;)

 :D That reminds me. Does maraviroc work in the brain too? I've noticed I'm a lot more forgetful since being diagnosed - I'm not on meds and have a high VL. Not sure if it's stress or what...
Diagnosed January 2006
26/1/06 - 860 (22%), VL > 500,000
24/4/06 - 820 (24.6%), VL 158,000
13/7/06 - 840 (22%), VL 268,000
1/11/06 - 680 (21%), VL 93,100
29/1/07 - 1,020 (27.5%), VL 46,500
15/5/07 - 1,140 (22.8%), VL not done.
13/10/07 - 759 (23.2%), VL 170,000
6/11/07 - 630 (25%), VL 19,324
14/1/08 - 650 (21%), VL 16,192
15/4/08 - 590 (21%), VL 40, 832

 


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