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Author Topic: Anyone on Abacavir?  (Read 1871 times)

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Offline Cheo63

  • Member
  • Posts: 35
Anyone on Abacavir?
« on: February 16, 2007, 03:32:58 AM »
Hi Guys,

I am currently on Viramune, Epivir and Zerit.  My doctor has strongly advised me to replace Zerit with abacavir(Ziagen).  I'm just curious about the side effects.  When I was first started taking my meds there where no "warning" cards given to me.  Now, with abacavir, I've been given a warning card regarding the possible side effects.   Anyone want to share their experience with abacavir?

Thanks!

Offline Cerrid

  • Member
  • Posts: 499
  • only as good as your last haircut
Re: Anyone on Abacavir?
« Reply #1 on: February 16, 2007, 04:31:22 AM »
Hi Cheo63!

I've been on Epzicom (Kivexa) for 5 months now which contains both abacavir and lamivudine. I didn't get any side reactions from it. I agree, the warning card is really frightening. If there's a hypersensitivity reaction, it usually sets in between day 7 and day 11. But once you're past this, chances that you'll get the HSR later are very low.

Last year, there was much talk of a new gene test on a Brighton cohort which allows to predict whether a patient is likely to develop a HSR. Unfortunately, I don't know if this test has already entered the clinical practice around the world. You may check with your HIV doc. Meanwhile, here's some reading for you:

http://www.aidsmap.com/en/news/1933FB7E-BA61-4DF0-997D-F763C32925E1.asp
http://www.aegis.com/conferences/lipo/2006/14.html
http://www.i-base.org.uk/htb/v7/htb7-5/Use.html

Good luck!  :)
"Boredom is always counterrevolutionary. Always." (Guy Debord)

Offline edfu

  • Member
  • Posts: 1,084
Re: Anyone on Abacavir?
« Reply #2 on: February 16, 2007, 05:05:07 AM »
I've been on abacavir for 5 years, first in Trizivir, then in Epzicom.  I had no problems whatsoever.  I was lucky, I guess.  Everybody is different.
"No one will ever be free so long as there are pestilences."--Albert Camus, "The Plague"

"Mankind can never be free until the last brick in the last church falls on the head of the last priest."--Voltaire

Offline Londonguy

  • Member
  • Posts: 104
Re: Anyone on Abacavir?
« Reply #3 on: February 16, 2007, 06:02:46 AM »
The warning card is mainly in case of a hypersensitivity reaction I think.  Otherwise I think it's generally very good in terms of possible side effects.  I've only been on it for a week as part of Kivexa/Epzicom but I've had no side effects.  About 5% of people have a hypersensitivity reaction which is quite high.  When the clinic did my resistance tests they also did a test for abacavir sensitivity which came back negative.  I don't know how reliable it is but I would guess it dramatically lowers the chances of you having a HSR if it comes back negative. 

Offline budndallastx

  • Member
  • Posts: 463
Re: Anyone on Abacavir?
« Reply #4 on: February 16, 2007, 04:41:44 PM »
I originally was on Sustiva / Epzicom (Kivexa) but as it turned out, I had hypersensitivity to the Abacavir component.  The key is to refer to the card every day since some of the initial symptoms are subtle.  I had a very slight fever but it quickly developed into the rash and aching muscles.  If you start having the symptoms listed, call your physician and don't wait.  I thought it would pass and ended up hospitalized for several days.   

I have a couple of friends on the drug and they think it's easy to take and tolerate.

Meds since: 11/20/2006
Sustiva / Truvada
12/08/2008 VL:<48 CD4 622 (38%)   
9/8/2008 VL:<48 CD4 573 (30%)
5/2008 VL:<48 CD4 464 (30%)
1/2008  VL: <50  CD4 425(28%)
9/2007   VL: <50  CD4 465 (27%)
6/2007   VL: <50   CD4 443 (26%)
3/2007  VL: <50   CD4 385 (25%)
12/2006 - VL: <50   CD4: 384 (25%)
11/2006 - VL:  22K  CD4: 208 (18%)

Offline J.R.E.

  • Member
  • Posts: 7,162
  • Joined Dec-2003 Living positive, since 1985.
Re: Anyone on Abacavir?
« Reply #5 on: February 16, 2007, 04:51:13 PM »
Hello Cheo,

I was started on Viramune, Epivir and Zerit, back in October of 2003. It was my first regimen. After about 45 days, the doctor dropped the Zerit, and it was replaced by the ziagen. I have had good results with that regimen. Viread was added later on. It 's good that your switching from the Zerit to the Ziagen.

From the aidsmeds drug section :

 "Approximately 8% of people who take Ziagen are allergic to it and can experience a "hypersensitivity reaction." This can be serious and may require that Ziagen therapy be stopped. A hypersensitivity reaction usually appears during the second week of therapy, but it can take as long as six weeks to notice any symptoms. The most common symptoms are fever and rash, followed by headaches, stomach upset, feeling tired, sore throat, cough, and shortness of breath. These symptoms usually get worse over time and it is important that you report them to your doctor immediately."


http://www.aidsmeds.com/archive/2006_Aug_1589.shtml


Once again,. I had good results, and no problem with Ziagen. I currently take the Ziagen combined with the Epivir in the once a day pill, Epzicom.

If everything goes well with the change to Ziagen, the doctor could change that later on to Viramune and once a day  Epzicom.



Take care------Ray




« Last Edit: February 16, 2007, 04:53:36 PM by J.R.E. »
Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 12.5mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg



http://forums.poz.com/index.php?topic=40802.0

http://forums.poz.com/index.php?topic=45159.0

http://forums.poz.com/index.php?topic=39722.msg495621;topicseen#msg495621

http://forums.poz.com/index.php?topic=46806.0

http://forums.poz.com/index.php?topic=39414.msg491701#msg491701


 In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started my first  HAART regimen  on October 24th,03.

 As of 8/2514,  t-cells are at 402, Viral load <40

 Current % is at 11%

  
 62 years young.

Offline Cheo63

  • Member
  • Posts: 35
Re: Anyone on Abacavir?
« Reply #6 on: February 17, 2007, 02:47:10 AM »
Thanks guys for all of your imput.  I guess I just got a bit concerned because I never did get a warning card with Viramune, Epivir or Zerit.  I will start taking Abacavir starting in March so I will keep you posted as far as side effects are concerned.

Thanks again!!

Offline J.R.E.

  • Member
  • Posts: 7,162
  • Joined Dec-2003 Living positive, since 1985.
Re: Anyone on Abacavir?
« Reply #7 on: February 18, 2007, 06:12:12 AM »
Thanks guys for all of your imput.  I guess I just got a bit concerned because I never did get a warning card with Viramune, Epivir or Zerit.  I
Thanks again!!


I don't believe I ever received a warning card with those meds. I may have but I can't remember for sure. However, You should get a warning card with the ziagen ( Abacavir). That warning card does not come with every refill of Ziagen. If you are picking up your meds through a pharmacy, I am sure they would have those warning cards on hand to give you. They are wallet size. I carry mine with me, along with the other meds I am taking, just incase of emergency, And I am taken to the hospital, and unable to communicate. My partner also has a list of all my medications, that he could provide to those in the medical field, if they were to have to contact him. And they would contact him, that information is also in my wallet....Just in case.


Take care-----Ray
Current Meds ; Viramune, Epzicom, 40mg of simvastatin, 12.5mg of Hydrochlorothiazide.
Metoprolol tartrate 25mg



http://forums.poz.com/index.php?topic=40802.0

http://forums.poz.com/index.php?topic=45159.0

http://forums.poz.com/index.php?topic=39722.msg495621;topicseen#msg495621

http://forums.poz.com/index.php?topic=46806.0

http://forums.poz.com/index.php?topic=39414.msg491701#msg491701


 In October of 2003, My t-cell count was 16, Viral load was over 500,000, Percentage at that time was 5%. I started my first  HAART regimen  on October 24th,03.

 As of 8/2514,  t-cells are at 402, Viral load <40

 Current % is at 11%

  
 62 years young.

Offline dtwpuck

  • Member
  • Posts: 1,013
  • дано мне тело, что мне делать с ним?
Re: Anyone on Abacavir?
« Reply #8 on: February 18, 2007, 11:27:08 PM »
chiming in late here... but i've been on abacavir for five years.  It's one of the few meds i've been able to tolerate without any side effects.   
Floating through the void in the caress of two giant pink lobsters named Esmerelda and Keith.

Offline allopathicholistic

  • Member
  • Posts: 3,258
Re: Anyone on Abacavir?
« Reply #9 on: February 19, 2007, 09:00:00 AM »
Hi Cheo 63 I'm on abacavir via Epzicom. Personally I don't think abacavir has caused me any adverse side effects so that might be music to your ears

 


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