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Author Topic: What sorts of things can affect liver enzyme levels besides meds?  (Read 3062 times)

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Offline koi1

  • Member
  • Posts: 713
I am concerned about my liver enzyme levels. They were normalizing and now they are going up again. The only thing I can think of is stress and meds.

rob
diagnosed on 11/20/06 viral load 23,000  cd4 97    8%
01/04/07 six weeks after diagnosis vl 53,000 cd4 cd4 70    6%
Began sustiva truvada 01/04/07
newest labs  drawn on 01/15/07  vl 1,100    cd4 119    7%
Drawn 02/10/07
cd4=160 viral load= 131 percentage= 8%
New labs 3/10/07 (two months on sustiva truvada
cd4 count 292  percentage 14 viral load undetectable

Offline AustinWesley

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  • Posts: 815
    • HIV Discussion Group on Myspace!
Re: What sorts of things can affect liver enzyme levels besides meds?
« Reply #1 on: February 13, 2007, 08:25:45 PM »
Hepatitus is a major one.   

I'd imagine they tested you for that already though.   

Diag. 3/06  Infected aprx. 2 mo. Prior
Date        CD4   %      VL
4/6/06     627    32    36,500     NO MEDS YET!
6/7/06     409    27    36,100
8/23/06   408    25     22,300
1/2/07     354    23     28,700
2/9/07     139    30     23,000  Hep A Vaccine same day???
2/21/07   274    26     18,500 
3/3/07    RX of Truvada/Sustiva Started.
4/5/07    321     27      Undectable 1st mo.  
5/16/07  383     28    Undectable 2nd mo.
8/10/07  422     32   UD <48 on new scale!

Offline koi1

  • Member
  • Posts: 713
Re: What sorts of things can affect liver enzyme levels besides meds?
« Reply #2 on: February 13, 2007, 08:42:09 PM »
Yep, negative for B and C.


Thanks for responding.

rob
diagnosed on 11/20/06 viral load 23,000  cd4 97    8%
01/04/07 six weeks after diagnosis vl 53,000 cd4 cd4 70    6%
Began sustiva truvada 01/04/07
newest labs  drawn on 01/15/07  vl 1,100    cd4 119    7%
Drawn 02/10/07
cd4=160 viral load= 131 percentage= 8%
New labs 3/10/07 (two months on sustiva truvada
cd4 count 292  percentage 14 viral load undetectable

Offline AustinWesley

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  • Posts: 815
    • HIV Discussion Group on Myspace!
Re: What sorts of things can affect liver enzyme levels besides meds?
« Reply #3 on: February 13, 2007, 08:46:37 PM »
Well, I've heard a number of people claim liver issues from just starting HAART so probably it will adjust.

They didn't ck for A???

I just had the second vaccine for it.  You def. don't want it. 

I would imagine things will start leveling out.   Didn't you mention also you'd quit drinking?   That'd be enough to throw my system off ;)



Diag. 3/06  Infected aprx. 2 mo. Prior
Date        CD4   %      VL
4/6/06     627    32    36,500     NO MEDS YET!
6/7/06     409    27    36,100
8/23/06   408    25     22,300
1/2/07     354    23     28,700
2/9/07     139    30     23,000  Hep A Vaccine same day???
2/21/07   274    26     18,500 
3/3/07    RX of Truvada/Sustiva Started.
4/5/07    321     27      Undectable 1st mo.  
5/16/07  383     28    Undectable 2nd mo.
8/10/07  422     32   UD <48 on new scale!

Online RapidRod

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Re: What sorts of things can affect liver enzyme levels besides meds?
« Reply #4 on: February 13, 2007, 08:46:47 PM »
Alcoholism

Offline lydgate

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  • Posts: 1,022
  • Virgin, can't drive
Re: What sorts of things can affect liver enzyme levels besides meds?
« Reply #5 on: February 13, 2007, 08:47:01 PM »
Alcohol, obviously, also can.

Did they test you for hep A as well?

What are the levels? Are they slightly elevated or highly elevated? And what does your doctor say?
Her finely-touched spirit had still its fine issues, though they were not widely visible. Her full nature, like that river of which Cyrus broke the strength, spent itself in channels which had no great name on the earth. But the effect of her being on those around her was incalculably diffusive: for the growing good of the world is partly dependent on unhistoric acts; and that things are not so ill with you and me as they might have been, is half owing to the number who lived faithfully a hidden life, and rest in unvisited tombs.

George Eliot, Middlemarch, final paragraph

Offline JPinLA

  • Member
  • Posts: 148
  • Cheers!
Re: What sorts of things can affect liver enzyme levels besides meds?
« Reply #6 on: February 13, 2007, 09:01:55 PM »
Definitely what everyone has said...drinking often and a lot, hep A (since you already don't have B and C).  I'm surprised they didn't check for A along with B and C.  From what I understand your meds will definitely do that but I didn't realize so quickly unless it's an adjustment period.  Long term exposure to tylenol (acetomeniphin) could do it as well as diabetes. 
Since you're experiencing higher levels than normal I'm willing to bet it's the meds.
I would talk to your Dr. whenever you have concerns like these if at all possible. 

I'm not sure about stress but I'm sure it doesn't help.  I am a researcher for a large biopharm company and I know far too well the effects of drugs on liver function.  In fact, I am about to know intimately.  I would keep the jury out until you have another test to see if they keep climbing.  If they're no severely elevated, it's most likely a blip!

Lately if I have a patch of dry skin I'm on the phone to mr Dr.  He just loves me  ;)

Hang in there Rob and keep us updated!

JP
11/06 - Diagnosed - VL/5784 & CD4 326
2/07 - VL/6000 & CD4 290 2/07
3//07 -Began Truvada/Viramune 
4/07 VL/undetectable and CD4 320 22%
7/07 VL/undetectable and CD4 286 22%
11/07 VL/undetectable and CD4 302 26%

Offline koi1

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  • Posts: 713
Re: What sorts of things can affect liver enzyme levels besides meds?
« Reply #7 on: February 13, 2007, 09:20:52 PM »
Well,

The alcohol is not an issue now. After an MRI and and an Ultrasound that found now scarring from any source, plus I have not had a drink in three months. The dapsone could be an issue because it is in the same family of drugs that caused my liver function to go abnormal in the first place. I hope I will have some answers on Thursday, or at least possibilities.

Thanks JP. My mom does have later onset diabetes, but my bloods sugar has always been in the normal range.

rob
« Last Edit: February 13, 2007, 09:22:44 PM by koi1 »
diagnosed on 11/20/06 viral load 23,000  cd4 97    8%
01/04/07 six weeks after diagnosis vl 53,000 cd4 cd4 70    6%
Began sustiva truvada 01/04/07
newest labs  drawn on 01/15/07  vl 1,100    cd4 119    7%
Drawn 02/10/07
cd4=160 viral load= 131 percentage= 8%
New labs 3/10/07 (two months on sustiva truvada
cd4 count 292  percentage 14 viral load undetectable

Offline qrky

  • Member
  • Posts: 25
Re: What sorts of things can affect liver enzyme levels besides meds?
« Reply #8 on: February 13, 2007, 10:19:31 PM »
Alcohol
Tylenol
Nivarol (spelled that wrong)
Steroids
Preservatives in non-organic foods can be hepatoxic
Some herbs
Tetracyclines
Rifampin

Antioxidants (vitamin C, etc) can counteract liver damage.  Dapsone is described as an "oxidant" so if they're latin about it, ya, that could cause problems.  LOTS of prescription and OTC meds are bad for the liver.  You should inventory everything you're taking and check it out on the 'net.

-d

Offline koi1

  • Member
  • Posts: 713
Re: What sorts of things can affect liver enzyme levels besides meds?
« Reply #9 on: February 13, 2007, 10:32:19 PM »
Hey D-

I have told my docs all the OTC stuff. Currently only loperamide. They have a complete record of the lomotil, truvada and sustiva. I stopped all supplements to avoid any "noise" in the liver analysis. The more I think of it, the more I think it is the meds. Perhaps I am still getting used to this strong combo.

rob
diagnosed on 11/20/06 viral load 23,000  cd4 97    8%
01/04/07 six weeks after diagnosis vl 53,000 cd4 cd4 70    6%
Began sustiva truvada 01/04/07
newest labs  drawn on 01/15/07  vl 1,100    cd4 119    7%
Drawn 02/10/07
cd4=160 viral load= 131 percentage= 8%
New labs 3/10/07 (two months on sustiva truvada
cd4 count 292  percentage 14 viral load undetectable

Offline newt

  • Member
  • Posts: 3,877
  • the one and original newt
Re: What sorts of things can affect liver enzyme levels besides meds?
« Reply #10 on: February 14, 2007, 06:31:36 AM »
Food
"The object is to be a well patient, not a good patient"

Offline Coffeechick88

  • Member
  • Posts: 431
Re: What sorts of things can affect liver enzyme levels besides meds?
« Reply #11 on: February 14, 2007, 07:09:41 AM »
Alcohol, meds--including OTC meds, some supplements--"natural" health products can damage the liver as well, hepatitis or some other liver disorder,  strenuous exercise can briefly raise it, a gallbladder disorder such as gallstones blocking the bile ducts--you may also see ALP increased in addition to liver enzymes in that case, and there can be preanalytical variables that affect the results--if they left the tourniquet on too long, the blood was hemolyzed, etc you can have falsely elevated liver enzymes, so it can be a variety of things. 

Another thing to remember is to not look at just one set of lab results. 
Lucas James is here
Born 6-14-08 at 1233 am
8 lbs 14 oz, 22 in long

Offline cubbybear

  • Member
  • Posts: 510
  • Joined August 2005.
Re: What sorts of things can affect liver enzyme levels besides meds?
« Reply #12 on: February 14, 2007, 07:18:03 AM »
Diabetes, HIV can damage the liver, Recreational Drugs, Alcohol, Natural Supplements, Hepatic Cancer, Hep.. you name it.. there are countless things that can effect liver enzymes.
There's a bear in there!
Positive since 2000
Diagnosed 17/9/2005 CD4 35 VL 293,000
Meds 23/9/2005 Sustiva/Truvada
Currently CD4 232 VL Undetectable

 


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