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Author Topic: Gene therapy results due?  (Read 16009 times)

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Offline Jake72

  • Member
  • Posts: 145
Re: Gene therapy results due?
« Reply #50 on: April 10, 2007, 05:40:50 PM »
Thanks, NYCguy.  This is an interesting chart with a few surprises.   Who knew that dendritic cells had been picked up by U. Pittsburgh?   The cells have gone from that French/Brazilian study to the Far East to Canada to Pennsylvania.  Conspicuously absent from the chart are the Ensoli and Emory U. vaccines (unless they're there under some different names).

DermaVir is still in phase I (well, I/II)?  It seems as though that's been around for ages... 

Offline megasept

  • Member
  • Posts: 478
  • Steven here...
Re: Gene therapy results due? Hold Your Horses!
« Reply #51 on: April 11, 2007, 01:13:24 AM »
I met someone in my support group who had a gene therapy at UCLA which sounds similar to the Johnson/Tibotec mentioned above and he was off meds for over a year and good results no real increase in VL


Well, if GMAT reduces viral load to undetectable and keeps it there... Even if it's not forever
Isn't that sign enough that it works?
This is a general comment, not specific to this particular therapy and research.

On the second quote from a different poster, "No" it's not a sign that it works. You are assuming a causal relationship between some treatment, like GMAT, and good results. "Controls" are designed to isolate factors, so that your optimistic statement could be proven to be true. Very difficult process.

I was just skimming here and noticed a similar emotional current in this serious exchange and the not so serious over the probable "Bob Beck" quackery promoted by a new member to our site. Human beings want solutions. Some folks want a Jim Jones messiah to "cure" them with the secret substance the government/pharmas/white people/rich/corrupt MDs won't give us. And smarter folks may want results published right away and meaningful results from tiny samples (5 folks left in some study group), but science doesn't work so easily. This strong patient might have been in the control group receiving nothing for all I know. He could have been me. 

I am not part of that UCLA study, and I have long hoped for good things from gene therapy. Guess what? I had several VL measures of undetectable and a couple more under 1000 during the second and third years off meds. Does that sound exciting? Well, now past 6 years of no meds, my VL is climbing slowly and probably won't ever dip down below 10-20k without meds. My CD4s slowly and fairly steadily are dropping about 300 decline over 6 years. So there's no miracle here, just a pretty good immune system doing its best. Without a large sample and other measures, we don't know if this treatment has had any positive effect. So, let's not jump on a bandwagon. Good research usually leads to other good research. But progress is slow. Optimism is great, but if I hear "cure for hiv" (not from you guys or these researchers, I mean in general) one more time I'm gonna wretch. Better treatments working in entirely different ways, that's probably our future. Successful gene therapy still seems far off.
 8)  -megasept
« Last Edit: April 11, 2007, 01:32:32 AM by megasept »

Offline MitchMiller

  • Member
  • Posts: 480
Re: Gene therapy results due?
« Reply #52 on: April 11, 2007, 11:14:55 PM »
As far as the Ensoli trial goes, remember, they really just got started late last year or early this year in the phase 2 trials.  I would expect to hear nothing until near the end of the year or next year.  As far as I see it, no news is good news... it means the trial hasn't completely failed and is still ongoing... at least I would assume.  Also, I believe the start of phase 2 was delayed as they scrambled to get public funding.  Realistically, I'm hoping to see a therapeutic vaccine come to market in about 5 - 10 years (and it probably won't work for everybody.. and maybe not forever either).  Anything sooner is an unexpected surprise.

Offline hahaha

  • Member
  • Posts: 123
Re: Gene therapy results due? Hold Your Horses!
« Reply #53 on: April 12, 2007, 11:29:27 PM »
This is a general comment, not specific to this particular therapy and research.

[/i]
I am not part of that UCLA study, and I have long hoped for good things from gene therapy. Guess what? I had several VL measures of undetectable and a couple more under 1000 during the second and third years off meds. Does that sound exciting? Well, now past 6 years of no meds, my VL is climbing slowly and probably won't ever dip down below 10-20k without meds. My CD4s slowly and fairly steadily are dropping about 300 decline over 6 years. So there's no miracle here, just a pretty good immune system doing its best.
 8)  -megasept

Correct me if I am wrong, but obviously you are in some gene therapy experience and it sound like all the other meds that the virus start to mutate and resist against the "therapy" itself. right?

Sounds very depressing though :'( :'(
Aug 9, 2006 Get infected in Japan #$%^*
Oct 2006 CD4 239
Nov 2006 CD4 299 VL 60,000
Dec 1, Sustiva, Ziagan and 3TC
Jan 07, CD4 400

Offline lonbjny

  • Member
  • Posts: 27
Re: Gene therapy results due?
« Reply #54 on: April 13, 2007, 10:27:27 AM »
Hi hahaha,

I think, fortunately, you are misreading the thread.

He is merely stating that he has had experience of decreased viral load without gene therapy...therefore a decreased viral load on its own may happen independently of any therapy simply due to natural immmune system fluctuations, and so cannot be used, on its own, as proof that any particular therapy works.

Hope this helps (and I hope I read him correctly.

Stay optimistic.


Offline SASA39

  • Member
  • Posts: 690
Oct.     `06.  CD4=58  ?    %       VL not perform. ?!?
25.Dec.`06.         203       14        VL= 0
29.May.`07.    broken device        VL=1363
20.June`07     broken device        VL=0
25.Dec `07  CD4=582                  VL=70
14.May `08  CD4=448
29.July `08                                  VL=0
26.Nov `08  CD4=674                    VL=179
16.Mar `09  CD4=554                    VL=0
19.Jan`10 CD4=715               
03.Mar`10                                    VL=0
24.Aug`10 CD4=524                     VL=0
04.Dec`10 CD4=626                     VL=0
15.Sep`11                                   VL=93
17.Nov`11                                   VL=0
05/26 .Jul`12 CD4=713                 VL=0
28.Nov`12 CD4=916                     VL=0
09.May`13                                 VL=0

Offline Zanarkand

  • Member
  • Posts: 96
  • All Your Base Are Belong To Us
Re: Gene therapy results due?
« Reply #56 on: April 14, 2007, 09:20:14 AM »
Thanks SASA.
It seems we still might have to wait awhile for results on J&J GMAT
I hope they succeed!
I also wish they kept the community up to date <_<
All Your Base Are Belong To Us

Offline bmancanfly

  • Member
  • Posts: 595
  • Medicare For All !
Re: Gene therapy results due?
« Reply #57 on: April 14, 2007, 01:36:29 PM »
Regarding the trial results that were supposed to be released in Feb, and still missing.    Didn't someone in this forum say that they had corresponded with Michael Delane, the guy in the San Francisco trial, about his experience so far with the therapeutic vaccine.  He seemed very comfortable talking in the past.  Any way of contacting him now?
"The trouble with the world is that the stupid are cocksure and the intelligent are full of doubt."

 Bertrand Russell

Offline megasept

  • Member
  • Posts: 478
  • Steven here...
Re: Gene therapy results due? Thanks for CLARIFICATION!
« Reply #58 on: April 19, 2007, 03:13:03 AM »
Hi hahaha,

I think, fortunately, you are misreading the thread.

He is merely stating that he has had experience of decreased viral load without gene therapy...therefore a decreased viral load on its own may happen independently of any therapy simply due to natural immune system fluctuations, and so cannot be used, on its own, as proof that any particular therapy works.

Hope this helps (and I hope I read him correctly.

Stay optimistic.



Exactly, lonbjny! Sorry, had not been watching this thread closely. Thanks for correcting the misunderstanding. Yeah, misinterpretations (by us, not scientists) of data was pretty much my point. Cause and effect is the issue, my issue.

...And to HAHAHA, I find my medical history to this day pretty heartening, hardly depressing.

And no gene therapy ever (Pretty rare anyway) and only one treatment (3TC + D4T, 1995-2000). I don't volunteer for treatment studies just because I watch them...Sort of like I never buy a new model car the first two years of production...too many kinks left.   That's my preferred take on "new therapies"8) -megasept

 
« Last Edit: April 19, 2007, 03:16:36 AM by megasept »

Offline hahaha

  • Member
  • Posts: 123
Re: Gene therapy results due?
« Reply #59 on: April 19, 2007, 06:11:18 AM »
Thanks pal. 
Not a native English speaker, so sometimes I will misunderstand the words. 
But I gotta say, this "Research News and Studies" do give me lots of hope. 
The hope that keep me survive, and not being too depressed.

This forum is really really great to me.  Thanks to you all!
Aug 9, 2006 Get infected in Japan #$%^*
Oct 2006 CD4 239
Nov 2006 CD4 299 VL 60,000
Dec 1, Sustiva, Ziagan and 3TC
Jan 07, CD4 400

Offline hahaha

  • Member
  • Posts: 123
Re: Gene therapy results due?
« Reply #60 on: June 24, 2007, 09:23:03 AM »
Hi, last year I heard reports about a gene therapy phase 1 or 2 trial (involving Johnson & Johnson) that was due to release results in Feb 07.

It has approx 70 recruits with 50% on placebo.

One guy went public with his results as he had achieved undetectable viral load.

Does anybody know the trial. And does anybody know anything about the due date for results?

thanks


Another two months has gone and is there any update? 
Aug 9, 2006 Get infected in Japan #$%^*
Oct 2006 CD4 239
Nov 2006 CD4 299 VL 60,000
Dec 1, Sustiva, Ziagan and 3TC
Jan 07, CD4 400

Offline NYCguy

  • Member
  • Posts: 180
Re: Gene therapy results due?
« Reply #61 on: June 26, 2007, 04:29:43 PM »
Justin - are you still in touch with the guy from the SF Chronicle article?  Could you write him again and see if he could help us find out what's going on with these results?
Other ideas?
Thanks a mil!
11/9/06 = #$%^&!
sometime early Dec 2006:
CD4 530 20%/VL >250,000 (&*$$%!!)
started Reyataz300mg/Norvir/Truvada 12-27-06.
1/30/07 CD4 540 30%/VL <400
4/07 CD4 600+ 33%/VL <50
6/9/07 CD4 720 37%/VL <50
10/15/07 CD4 891 (!) %? VL <50
1/2010 CD4 599 (37%) VL<50 (drop due to acute HCV)
9/2010 - looks like HCV is gone for good! And I'm finally drinking again, thank GOD
2013 - considering a switch to Stribild. but I love my Kidneys (but I hate farting all the time!)...
June 2013 - switched to Stribild.  so far so good...

Offline NYCguy

  • Member
  • Posts: 180
Re: Gene therapy results due?
« Reply #62 on: September 20, 2007, 12:45:40 PM »
well guys, I wrote to J&J, which owns Tibotec and after about a month, I actually got a response.  To recap, this is the Johnson/Tibotec study where they put your blood through a dialysis-type machine and permanently alter your white cells to make them hiv-resistant.  This is not the Virxsys study Appleboy is trying to get into, but rather the one the guy referred to in the above SF chronicle article was in.  So we wait again:

Thank you for your interest in the above study. 

Unfortunately we experienced some delays in the implementation of this study and therefore it is still ongoing.  It is forecast that the last patient will complete last visit in Q1 2008, and the final results will be available Q2/3 2008.

I hope this answers your enquiry.

Kind Regards,

Sharon Patino
Clinical Trials Manager
Johnson & Johnson Research Pty Limited
11/9/06 = #$%^&!
sometime early Dec 2006:
CD4 530 20%/VL >250,000 (&*$$%!!)
started Reyataz300mg/Norvir/Truvada 12-27-06.
1/30/07 CD4 540 30%/VL <400
4/07 CD4 600+ 33%/VL <50
6/9/07 CD4 720 37%/VL <50
10/15/07 CD4 891 (!) %? VL <50
1/2010 CD4 599 (37%) VL<50 (drop due to acute HCV)
9/2010 - looks like HCV is gone for good! And I'm finally drinking again, thank GOD
2013 - considering a switch to Stribild. but I love my Kidneys (but I hate farting all the time!)...
June 2013 - switched to Stribild.  so far so good...

Offline Customer

  • Member
  • Posts: 98
Re: Gene therapy results due?
« Reply #63 on: September 20, 2007, 02:15:19 PM »

What would happen to HAART-sales if this kind of therapy becomes the standard therapy? Maybe the big companies who already have a number of HAART-meds on the market, are not interested in this kind of development...

Offline ScienceGuy25

  • Member
  • Posts: 120
Re: Gene therapy results due?
« Reply #64 on: September 21, 2007, 11:02:59 PM »
Hey All

There is a great article in a recent issue of Science on "Building an HIV-Proof Immune System." They list several current "gene therapy" clinical trials which are either going on now or about to start in the near future.

Unfortunately you can't easily get it online as you have to either subscribe to Science or be a member of AAAS.  And since I don't want to jeopardize my science career as it is just getting started I'm trying to avoid breaking any copy right laws.  At any rate this is the citation - you could get the article at the library if really interested.

Science 3 August 2007:
Vol. 317. no. 5838, pp. 612 - 614
DOI: 10.1126/science.317.5838.612

 


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